@matemanc

Computational immunologist focusing on #HLA in #infectious, #autoimmune diseases and #cancer. #immunology #immune #tumor #MHC #bioinformatics #immunotherapy

 Szeged, Hungary
immunoinfo.hu
Joined December 2013
  • Tweets1.2K
  • Following904
  • Followers741
56Media
I C U mutant! Our new paper is out! Our immune system doesn’t just fight viruses – it edits them. APOBEC enzymes introduce C>U mutations that often make viral proteins easier for HLA molecules and T-cells to detect, boosting immune recognition. nature.com/articles/s41467-0… #COVID_19
1
2
1
4
522
Mate Manczinger retweeted
Csaba Pal Laboratory@Csaba_Pal_LabOct 6
📢 Paper Alert! Grateful to have been involved in this amazing work by @research_lazar and SzilviaJuhasz labs, presenting a framework for dissecting pathogen-host-drug interactions. #Pathogen #Virulence #SingleCell #DeepLearning @SysbioS Check it at: shorturl.at/LQUFP 👇

Deep-learning single-cell profiling uncovers interbacterial and drug-driven reshaping of pathogen...

Nature Communications - This study introduces MALVINA, a deep-learning platform that measures bacterial invasion and DNA damage in individual human cells, revealing how bacterial interactions and...

nature.com
TheLazarLab@research_lazarOct 5
Counting bacteria is not enough. To understand what makes a bacterium dangerous, we need to see what it actually does when it meets human cells. Our MALVINA study is now out in @NatureComms
1
8
185
The story is not simply “broader is always better”. Broad HLA-II presentation may help against common pathogens, while more selective HLA-II variants may be advantageous in specific contexts, such as HIV. Full text: nature.com/articles/s41467-0… @matemanc

HLA-II peptide-binding diversity shapes humoral immune responses and susceptibility to infections

Nature Communications - Human leukocyte antigen class II (HLA-II) are involved in the presentation of peptides to helper T cells which guide in the B cell response and antibody production. Here...

nature.com
1
1
36
Individuals can carry different variants of HLA genes. Some HLA variants bind a broad range of peptide sequences, whereas others are more selective. Is this variation associated with susceptibility to infection? nature.com/articles/s41467-0…

HLA-II peptide-binding diversity shapes humoral immune responses and susceptibility to infections

Nature Communications - Human leukocyte antigen class II (HLA-II) are involved in the presentation of peptides to helper T cells which guide in the B cell response and antibody production. Here...

nature.com
1
1
2
13
929
more replies
Moreover, HLA variants with broader peptide-binding specificity are also associated with stronger antibody responses following influenza vaccination. Check out our article to learn more!
1
1
78
It was a wonderful collaboration with Thomas Vogl at Medical University of Vienna and @SashaZhernakova at @univgroningen I am also grateful to my research group @BiologicalRese1 immunoinfo.hu
76
Mate Manczinger retweeted
BalintKintsesLab@KintsesLabJul 20
New paper out in @NatureComms We usually think of bacteriophages as viruses that interact exclusively with bacteria. Our work suggests the story is more complex: communities.springernature.c… We’d love your thoughts! @ApjokGabor #phages #microbiome #virome

Searching for the human-facing side of the virome

It all began with a simple question: if phages are so abundant in the human gut, do some of them physically interact with our own cells? We expected rare exceptions. Instead, we found adhesins...

communities.springernature.com
6
1
10
375
Mate Manczinger retweeted
Balazs Papp lab@balazs_papp_labJun 15
Can harmful gene loss become an evolutionary opportunity? In our new work in @OfficialSMBE, lab-evolved E. coli lines recovering from metabolic gene loss did more than return to normal: some surpassed wild-type on nutrients never seen during lab evolution. doi.org/10.1093/molbev/msag1…
1
5
1
10
701
Mate Manczinger retweeted
Eric Topol
@EricTopolJun 2
Big progress vs cancer, folks. The kind of event curves from randomized trials that we've not seen before for a couple of the most deadly cancers. Congrats to the oncology research community for getting these trial done. #ASCO26, @ASCO
35
480
28
2,415
127,574
A brief summary of our recent paper: "Five mutational “fingerprints” could help predict how visible tumours are to the immune system" eurekalert.org/news-releases… Link to our paper: link.springer.com/article/10… #Cancer #CancerResearch #Science

Five mutational “fingerprints” could help predict how visible tumours are to the immune system

Researchers from the HUN-REN Szeged Biological Research Centre and HCEMM have just published a new study suggesting that it’s not simply the number of tumour mutations that matters for immunotherapy,...

eurekalert.org
1
1
103
Mate Manczinger retweeted
HCEMM@HcemmSzegedFeb 5
Read the summary of our latest publication: Five mutational “fingerprints” could help predict how visible tumours are to the immune system, via @EurekAlert! eurekalert.org/news-releases…

Five mutational “fingerprints” could help predict how visible tumours are to the immune system

Researchers from the HUN-REN Szeged Biological Research Centre and HCEMM have just published a new study suggesting that it’s not simply the number of tumour mutations that matters for immunotherapy,...

eurekalert.org
1
3
114
Mate Manczinger retweeted
Caleb Lareau
@CalebLareauJan 28
⚠️ If you’re reading this, you’ve been infected* ⚠️ *~95% the human population has been infected by the Epstein-Barr Virus (EBV). Today in @Nature with @nyeo_sherry, @EMC22381830, @RyanDhindsa @SlavePetrovski, we shed some light on what happens next. nature.com/articles/s41586-0…

Population-scale sequencing resolves determinants of persistent EBV DNA

Nature - Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence...

nature.com
22
135
23
491
108,287
Our new paper is out: Five dominant amino acid substitution signatures shape tumour immunity link.springer.com/article/10… Thread 🧵⬇ #CancerResearch #cancer #tumor #immunesystem #Science #sciencenews

Five dominant amino acid substitution signatures shape tumour immunity

Molecular Systems Biology - Although numerous mutational processes operate in cancer, their functional impacts are unclear. We hypothesised that certain mutation sources preferentially generate...

link.springer.com
1
2
3
9
658
more replies
8/ But there’s nuance inside AAS4: Among AAS4-driven tumors, specific HLA variants are enriched in immune-hot cases. So antigen presentation genetics may modulate whether an AAS4 tumor ends up “cold” vs “hot.”
1
43
9/ Takeaway: Protein-level mutation patterns provide a complementary lens to DNA mutational signatures—linking mutagenesis + repair defects to peptide properties, immune contexture, and therapy response.
42
Load more