ChemicalBiologists, all things small molecule at the corner of science and nature
Boston, MA
Joined March 2009
- Tweets208
- Following183
- Followers282
- Likes637
Pinned Tweet
In the recent issue of @nchembio we report the development of #CoraFluors, a #novel class of bright and stable TR-FRET donors optimized for biological #application, including measuring the binding of drug molecules to their targets, directly in #livecells and in real time 🧪(1/n)
The cover of our November issue (nature.com/nchembio/volumes/…) features a class of luminescent terbium-based probes called CoraFluors (nature.com/articles/s41589-0…) used for detecting ligand-bound protein targets by TR-FRET.
Ralph Mazitschek retweeted
Voices: @antolin_aa, Yimon Aye, @LironBarPeled, @Elena_De_Vita, @nata_dudkina, @MichaelCJewett, @hannahjanekc, @mazit, and @SZhangJerry define "What is Chemical Biology." dlvr.it/TDRhvs
Ralph Mazitschek retweeted
Excited to share 2 preprints, together showing how mechanisms of a molecular glue & E3 ligase cancer mutations serendipitously converge to cause neomorphic protein degradation in distinct contexts. Highlights below: 1/17
#1: biorxiv.org/content/10.1101/…
#2: biorxiv.org/content/10.1101/…
Rockstar work championed by @Chemist_Payne and Saki Ichikawa synergistically combines #CoraFluors and #Cyclimids into a powerful platform approach to accelerate degrader development and comprehensive characterization.
Our newest work in collaboration with Saki Ichikawa and @drcmwoo @mazit is now online @CellChemBiol! Here is a free-to-read link:
authors.elsevier.com/c/1iYPc…
Awesome collaboration with #BullockLab and @Chemist_Payne! Combining our complementary expertise, we shed new light on the CUL-3-KEAP1 complex, establish a straightforward assay to measure CUL3 binding to its adaptor proteins, and reveal CDDO’s activity as a “partial antagonist”.
The Bullock lab @CMDOxford has a new paper on KEAP1-CUL3 structure, TR-FRET and inhibition by CDDO. Great collaboration with Ralph Mazitschek @mazit DOI: doi.org/10.1016/j.freeradbio…
I wonder if we will see certain footage played in reverse to suggest some “visitors” just came to fix things that were broken.
Ralph Mazitschek retweeted
My Saturday fun project: using AI, every US president as a Pixar character.
Ralph Mazitschek retweeted
Preprint out!
KEAP1-CUL3 structure, an awesome new assay platform for BTB domain-containing proteins, and elucidating the mode of inhibition of CDDO...what a fantastic collaboration @mazit @MGHCSB @CmdOxford
biorxiv.org/content/10.1101/…
Ralph Mazitschek retweeted
Authors @mazit @Mark_A_Tye @Chemist_Payne @dyann_wirth @LabOppermann @MGHCSB @HarvardChanSPH @broadinstitute @UniofOxford develop prolyl-tRNA synthetase high affinity inhibitors as antimalarials from a single-step biochemical assay.
go.nature.com/3AUW5NK
#Malaria remains one of the deadliest infectious diseases🦟. The spread of resistance to existing therapies threatens 🌍eradication efforts. Today we share some of our recent work aiming to exploit novel targets for new antimalarials💊 to address this urgent public health need.1/
Also thanks to our institutions and funding support @MGHCSB, @MGH_RI, @broadinstitute, @HarvardChanSPH, @broadinstitute, @UniofOxford, @HarvardCCB, @chemical_phd, @NIAIDFunding, @NSF, @scienceinboston 11/
P.S. Like many folks on #ScienceTwitter, we have also encountered hostile🗡️ referees during the review process of this manuscript. I am grateful🙏 to the editor for recognizing this and not taking the easy way out but recruiting additional referees. 12/