@meslier_q

PhD candidate at Northeastern University | Shefelbine lab | Bone mechanoadaptation in 🐁

 Boston, MA
shefelbine.org/
Joined April 2021
  • Tweets19
  • Following207
  • Followers121
5Media
Quentin Meslier retweeted
Tim Boyer@Boyer_TL22 Apr 2025
Excited to share my first first-author paper! A big thank you to my wonderful co-authors. Check it out 50 days free:
Bajpayee Lab@BajpayeeLab22 Apr 2025
Calling all Disease-Modifying OA Drugs‼️ We are excited to share new work led by @Boyer_TL now published in @OACJournal on evaluating Cationic Peptide Carriers for drug delivery of DMOADs in an animal model of post-traumatic osteoarthritis. Free Access: authors.elsevier.com/c/1kyZk…
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🚀 New preprint from the Shefelbine Lab! doi.org/10.1101/2025.02.05.6… 🦴Yoda2 + tibia loading combination enhance mechanoadaptation in 22-month-old mouse bones. Preliminary in vivo calcium imaging suggests Yoda2 reaches osteocytes in old mouse bones @ORS2025 2/8, 4:15pm North 221
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The WISH-BONE method paper, presented at #ISBM2024 last week, has now been published and is available on FASEB: doi.org/10.1096/fj.202400635… We’ve added 3D labeling examples of Ocn Knockout mouse bones. @ISBM_society ,ShefelbineLab,@monaghan_lab, @LifeCanvasTech
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Thank you yo Dr. @GiuliaMontagna7 and Dr. Warman for their help with the transgenic mice.
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Malluche Awardee are presenting high level of bone research #ISBM2024. @meslier_q is presenting his novel whole-mount in situ protocol to label osteocyte mRNA. We are proud of your work Quentin 👏👏👏
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Excited to share our new preprint! We used WISH-BONE to investigate the 3D spatial regulation of Sost and Sclerostin after in vivo tibia loading. doi.org/10.1101/2024.09.23.6… Shefelbine Lab,@monaghan_lab, @LifeCanvasTech WISH-BONE methods (in press): doi.org/10.1101/2024.03.14.5… (1/2)
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@monaghan_lab @LifeCanvasTech
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Part of this work will be presented next week at ISBM 2024, in Toronto @ISBM_society. Looking forward to it! (2/2)
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We are proud to announce the 2024 class of @ISBM_society and @ASBMR Hartmut H. Malluche Early Career Investigator Awardees! This competitive award honors Dr. Malluche's contributions to founding the society while elevating our next generation of leaders in the field.🌟
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Excited to share our new method preprint, WISH-BONE, to label osteocyte mRNA and protein in 3D mouse bone, presented at #ORS2024. Collaboration between ShefelbineLab, @monaghan_lab, and @LifeCanvasTech. Stay tuned for videos! biorxiv.org/content/10.1101/… @ORSsociety, @NUBioE1
Whole mount HCR FISH in mouse tibia. A) 3D view of a mouse tibia midshaft labeled for Sost. B) Cross-sectional 2D view of the 3D mouse tibia midshaft showing Sost expression in the cortical bone. C) Zoom on the cortical bone showing expression of Sost (arrow with circle) and Dmp1 (plain arrow) through the cortical thickness. Osteocytes expressing both Dmp1 and Sost appears white (double-headed arrow). D) Zoom on the cortical bone showing colocalization of Sost signal and nuclear staining (plain arrow). E) Negative control. The sample was incubated with fluorescent DNA hairpins without prior incubation with probes. White arrows show autofluorescence of a blood vessel and some remaining part of bone marrow. Images were acquired via lightsheet microscopy. Dotted lines highlight the cortical bone.

ALT Whole mount HCR FISH in mouse tibia. A) 3D view of a mouse tibia midshaft labeled for Sost. B) Cross-sectional 2D view of the 3D mouse tibia midshaft showing Sost expression in the cortical bone. C) Zoom on the cortical bone showing expression of Sost (arrow with circle) and Dmp1 (plain arrow) through the cortical thickness. Osteocytes expressing both Dmp1 and Sost appears white (double-headed arrow). D) Zoom on the cortical bone showing colocalization of Sost signal and nuclear staining (plain arrow). E) Negative control. The sample was incubated with fluorescent DNA hairpins without prior incubation with probes. White arrows show autofluorescence of a blood vessel and some remaining part of bone marrow. Images were acquired via lightsheet microscopy. Dotted lines highlight the cortical bone.

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We're a week away from the #FutureORSPostdoc Poster Session! Stop by the poster hall on Mon 2/5 at 7pm to meet 15 great early career investigators, including Quentin Meslier (@meslier_q), who works on tools for investigating bone mechanoadaptation! 🦴 #ORSSMC
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Quentin Meslier retweeted
Nilsson Holguin@HolguinLab28 Jul 2022
Post doc job 🚨. The HolguinLab will be accepting applications for motivated and collaborative PhDs excited to pursue cutting-edge research on discuskeletal interactions at NYC’s own @MountSinaiOrtho. Interested applicants can DM or email me. RTs appreciated.
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Quentin Meslier retweeted
James Padgett, PhD@JBPtweets26 Jul 2022
Great Harold Frost Presentation by @EfrosiniTsouko on NF1. @ORSsociety #ORSMBW – at Utah, USA
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Great way to kickoff the blue ribbon presentations session by @JBPtweets Excited to learn more about it during the poster session tonight. #ORSMBW @ORSsociety
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Quentin Meslier retweeted
James Padgett, PhD@JBPtweets24 Jul 2022
Nice blue ribbon poster presentation by @meslier_q on fluid flow in bone loading. So much great science already in the first day at the ORS Biology Workshop! @ORSsociety
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Image of the Week: Cross-sectional view of whole-mount mouse bone. Imaged on @zeiss_micro Lightsheet Z1 #FluorescenceFriday #Imaging #Microscopy Credit: @meslier_q from Shefelbine Lab
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Image of the Week: HCR FISH in mouse bone cryosection imaged via @zeiss_micro LSM 800 confocal #FluorescenceFriday #Imaging #Microscopy Credit: @meslier_q / Shefelbine Lab, Northeastern MIE @NUBioE1 @NortheasternCOE
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