In September @Invivyd said to expect the (now twice delayed) topline data from the VYD2311 DECLARATION phase three trial in October so we'll see if they deliver this week. They are no longer planning to unblind efficacy data, and will just share safety and immunogenicity. We already have a good idea re: immunogenicity from LIBERTY.
$IVVD is approaching record lows.
I'm long on $IVVD as a retail investor.
investors.invivyd.com/news-r…
Is @NYCMayor the first mayor of a major US city to do a collab with an OnlyFans “creator”?
Designed and 3D printed the Theranos Edison popcorn bucket for You Can See Everything that theaters didn't have the courage to make.
Free STL up on - Karolian.com
You can buy one on Etsy, but you shouldn't.
etsy.com/listing/4602335871/…
Matt Karolian retweeted
If you think Midtown Manhattan in the afternoon is much, much sketchier than it used to be, you're right thebiggerapple.manhattan.ins…
Matt Karolian retweeted
New at Media Nation: @BostonDotCom shifts to mostly paid as Globe Media CEO Linda Henry says the economics of free news no longer works. dankennedy.net/2026/10/20/bo…
What has Ford done to make their batteries last much longer than Tesla?
A 2022 Ford Mach-E has crossed the 400k mile mark!
Check out this post from FB from the owner. If he’s on X, let me know! I’d love to give him a follow.
Pretty amazing how reliable it’s been.
Even more amazing is that his battery has only degraded 10-11%. That’s about the same as most new Teslas degrade in their first year, regardless of mileage. 🤯
Matt Karolian retweeted
Multiple Sclerosis (MS) has long been a mystery
Genetics, Infections,…?
Prior research shows almost outbreak like patterns
I am delighted to have been a part of this stellar research group - linking MS to exposure with Epstein-Barr virus infection
science.org/doi/10.1126/scie…
Matt Karolian retweeted
The Libertarian Party of New Hampshire, a far-right group that was recently cut off from the national Libertarian Party, appears to be suspended for violating X’s rules. This is something state leaders asked for after LPNH repeatedly endorsed political violence.
FWIW nobody has told me they were going to decapitate me and my family on Threads. That’s only happened on X.
Last year I thought Threads was an existential risk to X.
When Meta puts its full weight behind something -- by injecting the app into Instagram, it’s DEFCON 5:
You have to squeeze out every last drop of growth from all available surfaces to save the app.
However, I started to realize that the opposite was happening:
It was strengthening X.
If you look at any announcement by Zuck, you will see the most rude & toxic comments on the internet.
But when he makes those same announcements on X, people are thrilled about how he’s pushing humanity forward. X is a place where people are excited about the future, so it’s no surprise he and his top lieutenants are using it more than their own app.
Threads — and Bluesky — have effectively quarantined some of the worst people on the internet.
And so I had an epiphany: those apps are X’s anti-abuse systems.
Matt Karolian retweeted
Also remember: Apple Upgrade is no longer Citizen Bank, it’s with Klarna which is a predatory lender that hates people with good credit and has terrible return policies. Buyer beware.
We handed a whole generation a bookie in their pocket, legal weed on every corner, dating apps with worse odds than a casino, and rent that eats half their paycheck.
We built a pretty efficient machine for making young people miserable, and then we wonder why they're not alright.
I used to drive this regularly, it really is such a dangerous spot
Investigation continues into that deadly drive on the Arborway in Jamaica Plain yesterday that was caught on dash cam video obtained by 7News…18 year old driver who caused the crash remains hospitalized…the other driver a 48 yr old man was pronounced dead at the scene #7News


























