Lecturer - Computational biologist. Bit of a muppet. Interested in genome architecture, gene regulation and WNT signalling. Addicted to tea! All views my own
Joined April 2010
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looking to develop your computational biology skills ..... we have an new MSc course running at Cardiff uni this year! take a look ... cardiff.ac.uk/study/postgrad…
interested in understanding non-coding conservation and genome evolution? I have a PhD position in my group looking at the evolution of regulatory domains in annelids swbio.ac.uk/files/2025/11/sw… .... 100% computational biology PhD ... e-mail me if you want to discuss further
New preprint describing and testing a potential mechanism for how Wnt signalling represses target gene expression ..
biorxiv.org/content/10.1101/…
Two key findings ....
1. In HPAF-II (RNF43 mutant PDAC) only 10% of genes are b-catenin independent
2. A subset of the Wnt-repressed genes is enriched for the NRE motif (Kim et al) and we subsequently test its function repressing a lncRNA and modulating AXIN2 expression
.... this implies that b-catenin independent signalling only plays a minor role (transcriptionally?) in Wnt-addicted PDAC and that their might be a regulatory grammar that determines whether a Wnt target gene is activated or repressed in response to pathway activation
PhD position available (via SWBIO DTP) to design statistical methods to identify and test for differences between RNA secondary structure using HTS data - bpb-eu-w2.wpmucdn.com/blogs.… ... Deadline - Midnight, Wed 11 Dec
applications details - findaphd.com/phds/project/de…
Nathan Harmston retweeted
Research Assistant Job Opp in Singapore @NUSMedicine !
Oncology and neurology combined. Cancer-related stroke (CRS), an emerging subtype of ischemic stroke. Join us to find mediators of CRS, and develop screening and prevention strategies for stroke in patients with cancer.
By integrating a "lot" of epigenomic datasets, we identified how the non-canonical NF-𝞳B pathway regulates enhancer activity in multiple myeloma .. lots of interesting findings in this work (and lots of data for proud research parasites) .. congrats to everyone involved!
Aberrant non-canonical NF-κB signalling causes epigenomic reprogramming leading to transcriptional changes that favours multiple myeloma progression. @YinghuiLi4 @CriticalSci @KamaakshiD @npharmston @ntusbs @sciencentu @NTUsg @NUSingapore @cardiffuni
nature.com/articles/s41467-0…
What does Otk actually do in Wnt signalling? Through a combination of microscopy and transcriptomics - we find more evidence supporting that Otk is the co-receptor for Wnt4, and that its paralog Otk-2 acts a negative regulator of Otk ... mdpi.com/2683814 #wnt
great computational Biology PhD opportunity at Cardiff university with the woman, the myth, the legend @SarahRLangley
2/ As part of this move, I’m now recruiting for a PhD student to continue our work on RNA processing in neurodegeneration! Please get in touch if you’re interested! findaphd.com/phds/project/in…
Nathan Harmston retweeted
The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/beta-catenin to RTK/MAPK signaling biorxiv.org/cgi/content/shor… #bioRxiv
Interested in gene regulation and promoter structure? ... looking a for PhD? Take a look at this project investigating how genes are regulated in drosophila testes!
PhD studentship opportunity. Come and work with me and @npharmston on gene expression and promoter architecture. Enjoy the excellent training provided by @SWBio_DTP and the great work environment in @CUBiosciences. findaphd.com/phds/project/ti…
interested in trying to understand how enhancers are conserved and how they work .... PhD position available now available at my lab at Cardiff University - Jan or Oct 2024 start - findaphd.com/phds/projectdet… - DM or e-mail me for more details!
Nathan Harmston retweeted
Three days left to apply for two postdoc position in regulatory genomics in our group!
Please RT, and get in touch if interested.
Come join us! Two postdoc positions in regulatory genomics-computational and a (mostly) experimental-available in our group to work on Metazoan promoters, enhancers, and their interaction.
Computational: nature.com/naturecareers/job…
Experimental:
nature.com/naturecareers/job…
Please RT.
Nathan Harmston retweeted
Last few days to submit an abstract! Great program lineup and venue in Singapore!
Exciting discoveries await! Submit your cutting-edge research to the upcoming GIW ISCB ASIA 2023 conference before the August 15th deadline. giw-sg.com/abstracts
