Genetic epidemiology. MRC IEU. Ruijin Hospital, Shanghai Jiaoting University School of Medicine.
Bristol, England
Joined February 2015
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Our recent efforts that estimates the effect of protein levels of ABO on pregnancy related outcomes: a Mendelian randomization study medrxiv.org/content/10.1101/…
Welcome to the 6th Sino-European lnnovation and Professiunal Devetopmment forum 2023. Three forum at Zurich, Lausanne and Helsinki
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Jie Zheng (Chris) retweeted
Mendelian randomization revealing the protective effect of sodium-glucose cotransporter 2 inhibition on prostate cancer with verified evidence from electronic healthcare and biological data medrxiv.org/cgi/content/shor… #medRxiv
Jie Zheng (Chris) retweeted
Our protein-wide MR analysis reveals many blood proteins in the development of type 2 diabetes and complications. Now online in @CellRepMed
Link 🔗 cell.com/cell-reports-medici…
A happy journey of this work with @oldz84 @LarssonSC
Jie Zheng (Chris) retweeted
My take on relationships between sclerostin and cardiovascular disease, and implications for selecting patients for Romosozumab
link.springer.com/article/10…
Jie Zheng (Chris) retweeted
#HKUSPH finds #metformin, an affordable medication for #type2diabetes, might promote healthy ageing using drug-target Mendelian randomization.
@ShanLuo7 @Ryan_Au_Yeung @Ian_HKU @ChuiCeline @oldz84 @ChristineYuanH1 @maryschooling
Paper @LancetLongevity: sciencedirect.com/science/ar…
Very interesting study found FTO variants rs1421085 T>C promotes brown fat thermogenesis, evidence from both human and mouse model.
Jie Zheng (Chris) retweeted
Thrilled to share that our work to explore the potential of metformin in longevity using genetics is now available at @LancetLongevity sciencedirect.com/science/ar…
Much appreciated @Ryan_Au_Yeung @Ian_HKU @ChuiCeline @oldz84 @ChristineYuanH1 @maryschooling @HKU_SPH @hkumed
Jie Zheng (Chris) retweeted
Taking a common diabetes medication after testing positive for SARS-CoV-2 reduces risk of developing #longCOVID by 40%, new study in @TheLancetInfDis finds
hubs.li/Q01SCsZj0
ALT Cumulative incidence of post-COVID-19 condition (long COVID) diagnoses over 10 months after randomisation.
Our recent efforts try to use MR-Clust to distinguish pleiotropy of omega-3 fatty acids instruments.
translational-medicine.biome…
Jie Zheng (Chris) retweeted
Exciting fully-funded #PhD opportunities at the @mrc_ieu @Bristol_Uni Interested in #multiomics #pregnancy and improving #AntenatalCare? Apply by June 5th and get it touch to find out more findaphd.com/phds/project/us…
Jie Zheng (Chris) retweeted
Our paper "The association between genetically elevated polyunsaturated fatty acids and cancer risk" is finally out. Many thanks to my collaborators and co-authors! Will try to do a tweet thread in the near future. sciencedirect.com/science/ar…
Jie Zheng (Chris) retweeted
Mendelian randomization suggests lower circulating sclerostin increases cardiovascular risk
pubmed.ncbi.nlm.nih.gov/3709…
A very nice conversation between Emma/Dylan and us was online in Diabetologia. Need to be very careful about what we are instrumenting when conducting drug target MR!
link.springer.com/article/10…
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@tomrgaunt @mendel_random @emmylooroll @dylan_wi11iams
Very nice piece of work from our brilliant PhD candidate Huiling Zhao @leu1226 🌟🌟🌟
Such an honour to be part of GBMI! Great honour to collaborate with big names: Ben Brumpton, Wei Zhou, Ben Neale and Tom Gaunt. Hope this will open the door for multi-ancestry proteome-wide MR.
“Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases"
@weizhouw @bmneale @tomrgaunt @oldz84
cell.com/cell-genomics/fullt…
Jie Zheng (Chris) retweeted
So excited to see the flagship and 7 more GBMI papers online today. It’s such a honor to work with the great team led by @bmneale, @cristenw, @dalygene, @genetisaur coordinated by @sineadbchapman. Big thanks to biobanks and their participants for making our research possible.
Check out the first studies from the Global Biobank Meta-analysis Initiative @GlobalBiobanks offering guidance on making #GWAS more diverse and representative. Now published in @CellGenomics
Jie Zheng (Chris) retweeted
New preprint available 🥳
(with @clara_albi, @bpasaniuc, @bvilhjal)
We present a new version of LDpred2-auto and validate it for inference of genetic architecture parameters.
This figure gives a summary of what LDpred2-auto can give you now:
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Inferring disease architecture and predictive ability with LDpred2-auto biorxiv.org/cgi/content/shor… #bioRxiv
Such a nice review lead by Venexia @venexia 😀
🚨NEW REVIEW PAPER WITH @oldz84 @tomrgaunt @mendel_random 🚨 Phenotypic Causal Inference Using Genome-Wide Association Study Data: Mendelian Randomization and Beyond shorturl.at/dgUX2
very nice piece of work from Jamie Robinson. Like a dream come true. Hope PWCoCo can add value to future colocalizaiton analysis
New preprint led by Jamie Robinson, @tomrgaunt, @oldz84! Privileged to be on the team with my Biogen colleagues @YunFengHuang618, @denis_baird, @eatsai.
An efficient and robust tool for colocalisation: Pair-wise Conditional and Colocalisation (PWCoCo) biorxiv.org/content/10.1101/…
