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New in @CellCellPress: Stem cells self-organize into models of early development, but even under carefully controlled conditions, the resulting organoids exhibit substantial “inter-individual” heterogeneity. To explore its origins, researchers generated monoclonal gastruloids, each derived from a single mESC. Congratulations to first authors Samuel Regalado of @UW, Chengxiang Qiu (@CXchengxiangQIU) of @GeiselMed, and colleagues! #StemCellResearch #Gastruloid #Organoid

First authors Thi Thom Tran, Thi Tu Uyen Phan, and Michael Baboudjian, and colleagues from Aix-Marseille University adapted previously described protocols to establish a biobank of #ProstateCancer patient-derived tumor #organoids, achieving a high initial growth success rate. 🧫 bit.ly/4zKVAl4

Exciting organoid news that's out of this world!🌎👇 @NationalSCF announced the launch of its seventh mission to the #InternationalSpaceStation carrying the first Cosmic Organoid Villages™! 🚀 Read more: bit.ly/4Bej5o4

This review discusses the development of photoreceptor replacement therapy using #iPSC-derived #RetinalOrganoids (ROs). 🧫 bit.ly/4iaRHzG The authors discuss early studies investigating donor cell integration and host-graft interactions, recent progress in retinal sheet transplantation, and the first clinical applications of iPSC-derived ROs.

This study in @CurrentBiology combined an in silico vertex model with live imaging of murine intestinal #organoids, showing that mitotic shape changes drive a spatiotemporally segregated sequence of cell-contact rearrangements. 🔗 bit.ly/4ASJCXH

The authors discuss four approaches for building #BreastCancerOrganoids, including: 1️⃣ patient-derived tumor organoids 2️⃣ gene-edited models 3️⃣ microenvironment reconstruction via multicellular co-culture 4️⃣ organoid-on-a-chip platforms. 📖 Give it a read: bit.ly/4rNRYvw

A new review to get you talking! 🗣️ Human #organoid and organoid‑on‑chip platforms expand the experimental toolkit for neural tube defect research and show potential for developmental toxicity assessment, risk‑factor screening, and patient‑specific disease modeling. | @SpringerNature 🆕 Give it a read: bit.ly/4heOdKT

🐀 A new transplantation platform by the Pașca lab at @Stanford is making human brain tissue more accessible for study. The strategy neonatally engrafts the cortical cavity with human stem-cell-derived cortical organoids to generate xenocortical mice. 🔬 go.nature.com/4yegEQt

A new study is advancing #PrecisionMedicine by providing a more accurate platform to evaluate drug absorption and metabolism. This intestine-liver-tumor multi-organoid system is a step up for patient-derived #TumorOrganoids and drug assessment: bit.ly/4xIAp1o

Researchers established a transplantation platform using a genetic strategy to effectively deplete glutamatergic #neurons from mouse 🐭 neocortex and hippocampus and neonatally engraft the cortical cavity with human stem-cell-derived cortical organoids 🧫 to generate #xenocortical mice. Lean more: go.nature.com/4yegEQt @Nature | #OpenAccess

Researchers provided an organoid-based 🧫 platform for mechanistic investigation and personalized intrathecal therapy screening and proposed triple intrathecal therapy as a promising translational strategy for #DiffuseMidlineGliomas. 🔗 bit.ly/3SN4NcM | @CellCellPress

#Organoid monocultures' lack of immune components means that they fail to show how immune cells shape epithelial identity. Researchers created a new platform for studying epithelial-immune interactions by co-culturing macrophages in the intestinal niche: bit.ly/45URzNO

The Park lab (@Inhyun_P) at @Yale has identified DEAF1 as a critical regulator of #neurodevelopment. Mutations in DEAF1 leads to significant transcriptional alterations in human #CorticalOrganoids. See the paper in @ScienceAdvances: bit.ly/4xrPmEQ 📖 #OpenAccess

💸 @GreenstoneBio has been awarded a Breakthrough T1D Industry Discovery and Development Partnership grant to develop a T1D-derived islet cell platform aimed at understanding and protecting insulin-producing β cells in people with #Type1Diabetes. Learn more: bwnews.pr/4AdMSwr

#BrainOrganoids 🧠 can simulate critical processes of human neurodevelopment in both physiological and pathological states, providing an unprecedented window into the mechanisms and potential therapeutics of #AutismSpectrumDisorder. ▶️ Learn more: go.nature.com/46gD6MA

Investigators suggested that #trastuzumab treatment is associated with ferroptosis-related biochemical and molecular alterations in #HER2-positive breast cancer organoids, and that #p53-related signaling may participate in this process. 💡: bit.ly/4zU6cia

Analyze your #organoids SWIFT-ly! 🔎 This new workflow, SWIFT, from @EPFL uncovers dynamic Wnt-dependent morphological transitions, enabling scalable, high-throughput studies of epithelial plasticity: go.nature.com/4qYjGFN

Researchers developed vascularized #LungOrganoids from human iPSCs that model key features of COPD and pulmonary hypertension, providing a platform for disease research and precision drug discovery. Learn more here: ▶️ bit.ly/4h9Ubgf

Drs. @IreneFaravelli, Noelia Antón-Bolaños (@BolanosAnton), Paola Arlotta (@ArlottaLab), and colleagues from @Harvard and @broadinstitute demonstrated that #BrainOrganoids 🧠 transcriptionally age with cell type specificity over years in culture. Check out this article in @Nature: 🔖 go.nature.com/4zIkDWC

Scientists with Ozge Ardicli investigated the molecular and functional consequences of sodium dodecyl sulfate and cocamidopropyl betaine exposure in primary #eosinophilic esophagitis-derived esophageal #organoids and air-liquid interface cultures derived from biopsy tissue samples. 🧫 📚: bit.ly/4gpLdfv #OpenAccess 🔓