Mapping Cancer Biology Using Real Patient Tumors
San Francisco, California
Joined September 2025
- Tweets18
- Following0
- Followers1.3K
- Likes10
Pinned Tweet
Check out our YC launch!
Origin (@origin_bio) is using AI to make safer cell & gene therapies for diseases like cancer.
Their model designs DNA switches & dials to program precise gene expression patterns in disease cells.
Congrats on the launch @YashRathod_75 and @malhar317!
ycombinator.com/launches/PMG…
Origin retweeted
Today, we're excited to release 10,000 fully AI-designed enhancer sequences for the research community. Axis was prompted to design sequences with targeted activity in one of three widely used cell-lines.
AI allows us to explore a vast design space, going beyond the natural genome.
Origin retweeted
Muon can accelerate LLM training, but does that benefit transfer to regulatory DNA sequence modeling with its different data distribution? 🧬
Our results show that Muon with independent weight decay (MuonW) hits our validation perplexity target in ~37% fewer FLOPs than the best Adam configuration.
Origin retweeted
It was an honor to meet PM @narendramodi and discuss the potential impact of the work we are doing at @origin_bio
Interacted with CEOs of AI and deeptech StartUps at Seva Teerth. They are doing commendable work across sectors such as healthcare, agriculture, space, social enterprise and more. We discussed how to leverage the potential of AI in furthering the welfare of humanity.
pib.gov.in/PressReleasePage.…
Origin retweeted
Cell and gene therapies have the potential to offer a much higher quality of life to patients. Getting transcriptional control right is going to unlock a whole new class of them.
Happy to share a small preview into Axis’ ability to design novel regulatory DNA sequences. It’s so obvious that evolution has only explored a drop in the whole ocean. Now finally with AI can we start to take a deep dive.
Origin (@origin_bio) is using AI to make safer cell & gene therapies for diseases like cancer.
Their model designs DNA switches & dials to program precise gene expression patterns in disease cells.
Congrats on the launch @YashRathod_75 and @malhar317!
ycombinator.com/launches/PMG…
Origin retweeted
We're still in the early days of durable and long lasting drugs based on transcriptional control - similar to where mRNA medicines were many years ago!
With AI designed regulatory DNA and millions of sequences we're lab testing, we aim to precisely program gene expression @origin_bio
Origin (@origin_bio) is using AI to make safer cell & gene therapies for diseases like cancer.
Their model designs DNA switches & dials to program precise gene expression patterns in disease cells.
Congrats on the launch @YashRathod_75 and @malhar317!
ycombinator.com/launches/PMG…
Origin retweeted
Origin (@origin_bio) is using AI to make safer cell & gene therapies for diseases like cancer.
Their model designs DNA switches & dials to program precise gene expression patterns in disease cells.
Congrats on the launch @YashRathod_75 and @malhar317!
ycombinator.com/launches/PMG…
Read more about Axis in our blog here: origin.bio/introducing-axis/
Origin retweeted
Going on TBPN at 1:45 pm PT to launch @origin_bio and our model, Axis. Axis is the first model that generates regulatory DNA sequences and predicts its function.
Axis already outperforms DeepMind's AlphaGenome on various benchmarks!
Morning. On today’s show:
– @karimatiyeh (Ramp)
– @alexkshieh (The Antifraud Co)
– @dteare (1Password)
– @gilbert & @djrosent (Acquired)
– @sergiynest (Quilter)
– @jlopas (Base Power Co)
– @ryanjdaniels (Crosby)
– @zganieany (MeritFirst)
– @yashrathod_75 (Origin)
See you there.
Introducing Axis: the first AI model that generates regulatory DNA elements and predicts their function.
Gene therapies suffer from poor efficacy, toxicity & specificity. Models like Axis can help overcome such risks.
Axis beats Google DeepMind's AlphaGenome at predicting regulatory element binding activity by 6.7%.
We’re excited to take the model into the lab and open up public access soon!
To get early access to the model, please fill out the form here: tinyurl.com/origin-axis-acce…
If you enjoyed this thread and want to learn more about Axis, read our blog post: origin.bio/introducing-axis/
