@pRobM91

Research Fellow at University of Birmingham. I like plasmids. Co-founder of @ContamClub

 Birmingham, England
Joined June 2019
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‼️🚨🗓️ CONTAMCALENDAR 2025 🗓️🚨‼️ The ContamCalendar is back for another year! It’s a great one and we hope you’ll love it 🗓️🦠🧫🍄 Get yours here ➡️ contam.club ⬅️
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Happy Noodlococcus Day to all those who celebrate 🍜🦠 On this day in 2019, we discovered this noodle-y colony contaminating an old plate, leading to the creation of ContamClub 🧫✨
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Out latest preprint describes a plasmid lineage we've been tracking in Birmingham's QE Hospital - short 🧵👇 biorxiv.org/content/10.1101/… @alanmcn1

pQEB1: a hospital outbreak plasmid lineage carrying blaKPC-2

While conducting genomic surveillance of carbapenemase-producing Enterobacteriaceae (CPEs) from patient colonisation and clinical infections at Birmingham’s Queen Elizabeth Hospital (QE), we identi...

biorxiv.org
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It's been evolving in the hospital through the actions of smaller MGEs We've seen IS26-mediated inversions and acquisitions of various IS/transposons, including carriers of heavy metal resistance genes
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This project has been my first using only long-read sequence data (ONT 10.4.1) - it's been great - makes my days of assembling plasmids from short-read data + molecular work seem like a very long time ago...
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A new publication from my PDRA with @alanmcn1. Working with our UK-India collaborators, we screened the ability of non-antibiotic pharmaceuticals to cause genetic changes and cross-resistance to antibiotics (spoiler, not so much). nature.com/articles/s44259-0…

Non-antibiotic pharmaceuticals are toxic against Escherichia coli with no evolution of cross-resi...

npj Antimicrobials and Resistance - Non-antibiotic pharmaceuticals are toxic against Escherichia coli with no evolution of cross-resistance to antibiotics

nature.com
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I'll have some limited @ContamClub merch on hand too!
Rob Moran@pRobM9110 Apr 2024
Plasmid folk at #microbio24 - I'll be at B090 with a bonus poster showing some very new work, tracking plasmid lineages in a Birmingham hospital with long-read sequencing. Stop by if you'd like to hear more!
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Plasmid folk at #microbio24 - I'll be at B090 with a bonus poster showing some very new work, tracking plasmid lineages in a Birmingham hospital with long-read sequencing. Stop by if you'd like to hear more!
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If you're at #MicroBio24, come and visit posters B080 and B090 during the poster sessions, we've got some Contam Calendars and stickers to give out! 🦠
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If you're plasmid inclined, don't miss this!
Rebecca J Hall@DrRebeccaJHall10 Apr 2024
I’m talking about metabolism and MDR at 14:45 today, come along if you’re at a loose end! #microbio24
A schedule for Rebecca’s talk - 14:45 in Moorfoot entitled ‘Multidrug resistance plasmids commonly reprogramme expression of metabolic genes in E. coli’

ALT A schedule for Rebecca’s talk - 14:45 in Moorfoot entitled ‘Multidrug resistance plasmids commonly reprogramme expression of metabolic genes in E. coli’

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Izzie is an amazing PhD student in the McNally lab, definitely recommend going to see her!
Izzie Potterill@IzziePotterill10 Apr 2024
A great week at #Microbio24 so far, excited to present the start of my PhD work on conservation and variation in E. coli core genes at poster B052
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Ryan is an excellent presenter and he’s working on some really cool things, definitely recommend checking out his poster!
@teojcryan.bsky.social@teojcryan10 Apr 2024
Presenting a poster on my efforts at characterising metagenomes with De Bruijn graphs. Drop by poster B008 (delightfully palindromic) at #Microbio24 if you're keen to chat more!
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I’ll be presenting my poster today on in vitro evolution of Enterococcus at #Microbio24 come along to poster B055 if you want to find out more!
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Very happy have this out! I’ve been working on a couple of projects since joining @alanmcn1 and this is one of them - looking at the transcriptional response to multidrug resistance plasmids in E. coli. Thanks @AnnSnaith for the help on this too! journals.asm.org/doi/10.1128…

Multidrug resistance plasmids commonly reprogram the expression of metabolic genes in Escherichia...

The increase in infections that are resistant to multiple classes of antibiotics, including those isolates that carry carbapenamases, beta-lactamases, and colistin resistance genes, is of global...

journals.asm.org
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Rob Moran retweeted
David F@fozzz2117 Feb 2024
The new pre-print from the @GraingerLab! Really cool work mostly done by the talented @mulecc. Charles noticing a strange grey colony snowballed into this great story. – at East, England
bioRxiv Microbiology@biorxiv_micrbio17 Feb 2024
H-NS is a bacterial transposon capture protein biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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Excellent work from ⁦@DETECTIVE_AMR⁩ consortium. Big shout for ⁦@IbrahimxBa⁩ ⁦@pRobM91⁩ and ⁦@DrEmmaDoughty⁩ and colleagues in China. Also leadership of ⁦@alanmcn1⁩ and ⁦@WvSchaik⁩ nature.com/articles/s41467-0…

Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone

Nature Communications - In this work, the authors identified a hypervirulent carbapenem-resistant Escherichia coli ST410 clone which carries a high pathogenicity island and an O-antigen gene...

nature.com
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🔔New Pre-print🔔 TL;DR: The opportunistic pathogen A. lwoffii is more constrained in acquiring & developing antibiotic resistance 🦠 @JessicaMABlair @pRobM91 @friendlymicrobe @babs_clough @roscobacterium @FrickelLab @ma_webber biorxiv.org/content/10.1101/…

Differential development of antibiotic resistance and virulence between Acinetobacter species

The two species that account for most cases of Acinetobacter -associated bacteraemia in the UK are Acinetobacter lwoffii , often a commensal but also an emerging pathogen, and A. baumannii , a...

biorxiv.org
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Fun fact about this year's ContamCalendar - it was created entirely from a hospital bed after I spent 7 weeks in hospital following heart surgery. This surgery was actually partially related to both contamination and the ContamCalendars.... 📆🫀🩺🦠
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Introducing the ContamCalendar 2024 📆🦠🧫🍄 on sale tomorrow! Loved putting this together, can't wait for you guys to get your hands on this 💥 Retweet, like, and follow @ContamClub for your chance to win one 💥
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