Hematopathologist, cytopathologist, flow cytometrist, student, teacher, and nerd.
Stanford, CA
Joined March 2011
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40 year old man with retroperitoneal lymphadenopathy and spinal lytic lesions. Flow is negative. Any additional studies? @evemariecrane @hematopatho @hematogones @chriscogbillmd @SteveLongMD @DitaGratzinger @brent_tan
ALT Germinal center
ALT Plasma cell rich area
ALT Kappa immunostain in plasma cell rich area
ALT Lambda immunostain in plasma cell rich area
Congrats to @NaomiAkagiMD on an excellent platform presentation on body fluid supernatant NGS at USCAP! @drruizcor @diannang #ucsfcytopath
Textbook Warthins tumor in tail of parotid from a smoker. Imaging was worrisome for lymphoma based on necrosis @lucymhan @conniechenMD #UCSFcytology
Excited to be teaching ultrasound-guided FNA biopsy in Sydney with these incredible colleagues! You can see our setup with tofu and jello practice models in the photo. @UCSFcytopath – at Sydney, New South Wales
Spot on. Here are CD3, CD30, and ALK. ALK was also negative by flow. Our diagnosis is anaplastic large cell lymphoma, ALK-negative. FISH was negative for TP63 and DUSP22 rearrangements. NGS showed STAT3 Y640F and DNMT3A and DDX3X splice site mutations. Thanks for participating!
Great ideas all. Here are the EBER, HHV-8 and CD20 stains. Any other stain requests?
ALT EBV by in situ hybridization (EBER)
ALT HHV-8
ALT CD20
40 year old North African man presents with 2 weeks of shortness of breath, fatigue, cough, and subjective fever. Chest CT is markedly abnormal (attached). Thoracentesis is done. Diagnosis?#UCSFcytopath #UCSFcow @ekhanafshar @SteveLongMD @vighnesh_w @evemariecrane @chriscogbillmd
ALT H&E cell block
ALT MGG stained smear
ALT Pap stained smear
ALT Chest CT shows extensive bilateral pulmonary nodules and nodular consolidation with diffuse ground-glass opacity. Additionally, bilateral pleural effusions and hilar lymphadenopathy are present.
