🌌founder @stellation 🤝🏾partner to @skybysoftware @joinswsh @mainframe ++ 🎓alum @generalcatalyst @harvard @stuyny
New York, NY
Joined February 2010
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Peter Boyce II retweeted
we're starting to test a new app with designers @mainframe
DM or reply if you want to try
Peter Boyce II retweeted
Today, Coherence is announcing their $45M Series A from Founders Fund and OpenAI.
Topology was lucky to be Coherence’s first US institutional investor and co-lead their Seed round.
Thrilled for Ben, Elise and the team.
We’ve raised a $45m Series A, co-led by
@foundersfund and The @OpenAI Startup Fund, to build cancer therapy that learns. Technology is rapidly changing medicine, but data loops and rapid adjustments are still largely missing. When you start cancer treatment, knowing whether what you’re doing is working is too slow. Clearly there is a better way. Build systems to watch cancer in real time, then feed that data into a system that itself can treat the disease. This seeds a future where, unlike drugs, we develop medicine that continuously learns to improve itself. We've been building neurotechnology and BCI platforms to do just that.
@coherenceneuro
Peter Boyce II retweeted
In addition to everything you mentioned @dens, please factor in that you inspired a whole generation of entrepreneurs (including me) by showing them that:
- you can build a cool startup from NYC
- you can build something fun and that you care about
- you can persevere & stick to trying to build what you're excited about no matter what (it's the journey, not the destination!)
Thank you Dennis & team!
Foursquare was acquired last month. The outcome was disappointing. It's taken me a while to write this, but I think I'm finally done grieving it. Here are some thoughts on our final years, an effort to honor the team who helped build & maintain FSQ's legacy, and my attempt to finally get some closure. teendrama.substack.com/p/som…
Peter Boyce II retweeted
Fred Wilson on the simplest way to bet on AI:
“If you really want just a simple way to bet on AI and not have to think about all this other stuff, just bet on energy.”
Peter Boyce II retweeted
Last year we launched Tolan, inspired by a vision of AI that sees you and believes in you, not one that books restaurant reservations for you.
Your Tolan shows up for you at 3am when you’re alone with your newborn. On your commute when you’re anxious about the day ahead. When you just finished a new show and none of your friends have watched it yet.
The people who love Tolan are parents. Caregivers. Moms in Dallas and Dads in Atlanta. People who aren’t trying to optimize and be more productive, but who simply want to feel seen and supported in their aspirations.
This month more than 250k people will spend time with their Tolan. Those users have exchanged billions of messages across more than 70m conversations over the last year.
Today, we're announcing $30m in additional capital from @mignano and @usv, with @khoslaventures and @rabois doubling down, bringing our total capital raised to $60m.
To celebrate, we made a short film celebrating some of the ways that Tolans show up :)
Peter Boyce II retweeted
We've spent the better part of 2026 building the tools companies need to put AI to work: Stack, Token Spend Management, Router.com, and Glass.
Today we raised $1.85B at $60B valuation. There are now 85,000 businesses on Ramp saving a combined $1B+ a month.
We still have so much to build.
Peter Boyce II retweeted
NEW: Inside Thrive Capital w/ Partner Dr. Nworah Ayogu
Investing in Neuralink, OpenAI, Isomorphic Labs, OpenEvidence, Oscar Health & the next trillion-dollar healthcare companies.
@ThriveCapital manages $65B+ in AUM, having raised $10B+ for Thrive X earlier this year. Healthcare has been part of the firm's DNA since inception, with Josh Kushner incubating Oscar Health alongside Thrive itself.
The firm has incubated ~10 healthcare companies, the majority valued at over $1B, including Oscar Health, Cedar, Rightway & Cadence.
I sat down with Nworah (@nworahayogu), a Harvard-trained, board-certified physician & neuroscientist, former Amazon Clinic GM & Amazon Pharmacy's first Chief Medical Officer, to break down AI's next frontier in medicine.
We cover:
›› Isomorphic Labs: Demis Hassabis, AI-designed drugs & the race to compress drug development from 10 years to 4
›› Neuralink: $9B last funding valuation, brain implants, surgical robotics & restoring independence to patients with paralysis
›› OpenEvidence: $15B valuation, ~$300M annualized revenue & adoption by more than 65% of US physicians. Why AI could create 10X doctors
›› OpenAI: Why healthcare could become AI's most important use case, from clinical reasoning to personalized medicine
Thrive's thesis: Building companies that are world-class in both technology & medicine, with investments spanning Chai Discovery, Formation Bio, Nudge, Fortell, Nourish & more
“Because as a nation, I think we need a 10X nurse a lot more than we need a 10X engineer.”
𝐓𝐈𝐌𝐄𝐒𝐓𝐀𝐌𝐏𝐒
(00:00) Dr. Nworah Ayogu, Partner at Thrive Capital
(01:52) The next AI trade is hiding in biotech
(03:48) How AI designs a new drug
(08:37) 9 out of 10 drugs fail, can AI flip that?
(11:33) How Thrive got into Isomorphic Labs
(14:14) Giving paralyzed veterans their hands back
(20:39) Neuralink is more interesting than SpaceX
(23:21) The hearing aid that broke the rating scale
(30:18) The doctor who built Amazon Health
(33:21) Why AGI makes healthcare the biggest bet
(35:25) One cancer drug outearns every AI lab combined
(37:55) How Lilly became healthcare's first $1T company
(40:04) How Thrive helped OpenAI break into healthcare
(44:13) OpenEvidence: 2/3 of US doctors in 3 years
(46:16) Healthcare is 6x bigger than defense
(48:15) $40T spent, zero gain in life expectancy
(51:43) A custom gene therapy built for one baby
(55:47) Saving Medicare $2.5M a week
(1:04:13) Oscar's comeback from down 95% to up`1 100%
(1:06:19) Why OpenAI is now a giant healthcare provider
Peter Boyce II retweeted
This has been my experience. Agents help me handle life admin that is emotionally taxing or plain tedious.
This includes:
- coordinating elder care nurses
- moving logistics (finding, booking, and coordinating movers)
- sending gifts
- bill-tracking & so much more
My plate is both lighter and more full
We need more women building and playing with AI. AI is fun *and* so helpful, particularly for women. Dazzle.ai is designed for everyone, but, because it understands taste, brand loyalties, and the visuals of your life, it’s particularly well-suited for women. #FortuneMPW
Peter Boyce II retweeted
“The best people I’ve seen building things are playing” says @MattHartman, who wrote the first check into @huggingface (sold to Nvidia for ~$13B)
His approach is to find the newly technically possible, then find the founders already tinkering there. He's backed @factoryai, @modal & more.
Always a treat to chat & special shoutout to @mignano & @alxai_ referenced on the pod! 👋
.@MattHartman assumes every early-stage startup will pivot. That's why he backs technical founders who can "move with where the world goes." Now founder and managing partner of Factorial Capital, Hartman was part of the Betaworks team that wrote @huggingface's first check in 2016—when it was still a chatbot app for teenagers, before it became the largest community for open-source AI, set to be acquired by @nvidia for $13 billion. On this week's episode of The Every Podcast, he tells @NataliaZarina how he spots new opportunities, what makes a founder's insight worth backing, and why vibe-coding his own app gave him a new respect for SaaS.
Introduction
How Hugging Face went from a teen chatbot to the home of open-source AI
The three decisions that set Hugging Face on its path
Hartman's approach to finding the newly technically possible
Why Hartman backs technical founders
How Factorial’s portfolio founders source its next deals
Why faster iteration makes product insight the most valuable skill
What Hartman learned building Ghost Pepper, an open-source voice-to-text app
Hartman's current theses, from non-language models to full-stack AI apps
Why the best founders right now are experimenting
Peter Boyce II retweeted
When I was little the first career I decided on was “book fairy”.
Took a few decades but here we are 🤭 see you soon SF friends!
Coming soon (tomorrow!) — BUILT TO GROW, our field guide to creating excellent sales orgs, by the inimitable @she_travels.
I have a bunch of these taking up way too much space in our storage rooms. Would love to make some house calls this week to SF startups who are building their sales teams.
Email me (in bio!). And let me know if you’re a @stripe user!
Peter Boyce II retweeted
There are a few essays a year that totally shift my perspective on startups and strategy. This was one of those.
MSCHF has raised 11M from Founder's Fund, released over 100 products in the last 5 years, and has done so while being true to their taste.
every.to/napkin-math/the-art…
🐝 “The chief characteristic of any superorganism is that its power transcends the power of its parts. So the superorganism of AI, this AI environment, will transcend the power of its parts – which will include all the frontier models of the time, and the most powerful specialized AIs for math, or biology, or world building, and the general purpose everyday AIs running the back offices of corporations.” — @kevin2kelly kevinkelly.substack.com/p/sw…
Peter Boyce II retweeted
made a feed that automatically tracks the books im reading (and have read going back to 2012!)
maybe we should have a feed for everybody @every could be fun to see
Peter Boyce II retweeted
All plausible science fiction can be realized within our lifetime.
If you’re reading this, you’re one of the humans whose responsibility is to make the future Star Trek, not 1984.
Peter Boyce II retweeted
All plausible science fiction will be realized within our lifetime. If you’re reading this, you’re one of the luckiest humans to have ever been born (if we play our cards right.)
Peter Boyce II retweeted
Tired: Two-pizza teams
Wired: Two-slice teams
@danshipper on the best team structure in the AI-era