popfaarun (@popfaarun) profile picture

popfaarun

@popfaarun

PDRA in genome editing and metabolic engineering 🦠🧬🧪👩🏻‍🔬 part of @BrisBioDesign

 Bristol, England
Joined March 2019
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  • Followers162
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Photo by popfaarun (@popfaarun)Photo by popfaarun (@popfaarun)Photo by popfaarun (@popfaarun)Photo by popfaarun (@popfaarun)
Sebas' paper has just been published in @NatureComms! We report a strategy for optimizing protein production in which induction is dynamically adjusted based on the current stress of the cells to avoid the appearance of "burnt-out" cells. nature.com/articles/s41467-0… More below👇🏼
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Meet "Cheetah," an easy-to-use deep learning-based algorithm for single cell monitoring and control. From @Pedone_Elisa85, @marucci_lucia, @chofski, @mdiberna and colleagues @BristolEngMaths @BrisBioDesign  pubs.acs.org/doi/10.1021/acs… #cybergenetics #toolkit #tbt
Image from ACS Synthetic Bio (@ACSSynBio)
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20 years ago, synthetic biology was just a pipe dream. It was hard to engineer biology and ship product. It's now getting easier. Here's a list of 10 products of synthetic biology...
Image from John Cumbers (@johncumbers)
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Join us @Wallace_Lab for an exciting collaborative PhD opportunity with @De_Monchy_Group studying the design of new bacteria to convert🗑into fragrance & flavour compounds using #synbio. The application deadline is Friday 2nd June. Don't miss out! @SBSatEd @EdEngBio
Image from Stephen Wallace (@Dr_StephenW)
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Thanks @ioanagherman5 for leading this review @PLOSCompBiol on the use of machine learning and surrogate modelling in systems and synthetic biology! @chofski @pangweijlu @ZsAbdallah @PR0FG @BrisBioDesign
Image from Lucia Marucci (@marucci_lucia)
Thomas Gorochowski (@chofski) profile pictureThomas Gorochowski@chofski22 Apr 2023
Big congrats to @ioanagherman5 on her new review @PLOSCompBiol covering the complementary uses of mechanistic ⚙️ & #ML surrogate computer models for understanding and engineering biology 🦠. #synbio @marucci_lucia @PR0FG @BrisBioDesign doi.org/10.1371/journal.pcbi…
Image from Thomas Gorochowski (@chofski)
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👩‍🔬We have in Bristol a Lecturer/Senior Lecturer open position in applied maths for life sciences with encouragement for women or under-represented communities - deadline 11th April 2023, please RT! tinyurl.com/EngMathsJob @BristolUniEng
Image from Lucia Marucci (@marucci_lucia)
Alan Champneys (@Al_prof) profile pictureAlan Champneys@Al_prof21 Mar 2023
Please repost widely. DM me or @marucci_lucia for more details
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Use of zebrafish to study phage P1 against Shigella in vivo @ACSSynBio Great effort by Huan @VinTorraca @sydneylmiles @popfaarun @doyarzunrod Russell, Baojun pubs.acs.org/doi/10.1021/acs…
P1 Bacteriophage-Enabled Delivery of CRISPR-Cas9 Antimicrobial Activity Against Shigella flexneri

P1 Bacteriophage-Enabled Delivery of CRISPR-Cas9 Antimicrobial Activity Against Shigella flexneri

Abstract. The discovery of clustered, regularly interspaced, short palindromic repeats (CRISPR) and the Cas9 RNA-guided nuclease provides unprecedented opp

pubs.acs.org
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Very happy to get another paper out of the lab in @ACSSynBio. This time it’s phage P1 against Shigella flexneri! Thank you all the authors @MostowyLab @VinTorraca @sydneylmiles @doyarzunrod Huan, Russell and Baojun (not on Twitter) pubs.acs.org/doi/pdf/10.1021…. @SBSatEd @EdEngBio
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"Here, we developed a bacteriophage P4 cosmid system for the delivery of a Cas9 antimicrobial into clinically relevant human gut pathogens" From @popfaarun et al @SBSatEd @EdinburghUni @hiczju @ZJU_China  pubs.acs.org/doi/10.1021/acs… #CRISPR #antimicrobial #phage #delivery
Image from ACS Synthetic Bio (@ACSSynBio)
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Today's #shoutout to #womenInSTEM goes to Jidapha Fa-arun for her paper w/ the Wang Lab @ACSSynBio showing tail-engineered #Phage P2 Enables delivery of #Antimicrobials into multiple gut pathogens. pubs.acs.org/doi/10.1021/acs…
Tail-Engineered Phage P2 Enables Delivery of Antimicrobials into Multiple Gut Pathogens

Tail-Engineered Phage P2 Enables Delivery of Antimicrobials into Multiple Gut Pathogens

Abstract. Bacteriophages can be reprogrammed to deliver antimicrobials for therapeutic and biocontrol purposes and are a promising alternative treatment to

pubs.acs.org
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Very excited to be sharing my first first-author paper that has just published in @ACSSynBio today on phage tail engineering for targeting gut pathogens 🦠 pubs.acs.org/doi/full/10.102… @SBSatEd
Tail-Engineered Phage P2 Enables Delivery of Antimicrobials into Multiple Gut Pathogens

Tail-Engineered Phage P2 Enables Delivery of Antimicrobials into Multiple Gut Pathogens

Abstract. Bacteriophages can be reprogrammed to deliver antimicrobials for therapeutic and biocontrol purposes and are a promising alternative treatment to

pubs.acs.org
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Plastic waste has economic and environmental impacts and we need new routes to reuse and recycle. @JoSadler10 and @Dr_StephenW discovered bacteria can be used to convert plastic into vanillin, a valuable chemical used in food and cosmetics edin.ac/352Uq86 #BioWeekScot22
A plastic bottle found discarded on an Edinburgh street, that was broken down by bacteria and turned into vanillin.

ALT A plastic bottle found discarded on an Edinburgh street, that was broken down by bacteria and turned into vanillin.

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Exciting new preprint from Eligo Bio and David Bikard @dbikard 🇫🇷 - In situ targeted mutagenesis of gut bacteria biorxiv.org/content/10.1101/…
In situ targeted mutagenesis of gut bacteria

In situ targeted mutagenesis of gut bacteria

Microbiome research is revealing a growing number of bacterial genes that impact our health. While CRISPR-derived tools have shown great success in editing disease-driving genes in human cells, we...

biorxiv.org
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Successful 86day #phagetherapy & AB combination treatment of a young patient #MDR #Pseudomonas sepsis post liver transplantation Tracking #clinical #immunology #microbiology #virulence parameters #Research Coordinated by @PaulPirnay #article @NatureComms nature.com/articles/s41467-0…
Image from Rob Lavigne (@RobLavigne1)
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Very excited to be sharing phage research paper from our lab! If you want to learn more about the alternative tail fiber S’ of phage P1 then check this out: doi.org/10.1016/j.jmb.2022.1…
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The circulating phageome can identify bacterial pathogens in sepsis and other infections. Read all about it in our new pre-print by Naomi Haddock, @LaylaBarkal, Sam Yang, Ami Bhatt, and Charles Chiu. biorxiv.org/content/10.1101/…
The circulating phageome reflects bacterial infections

The circulating phageome reflects bacterial infections

Bacteriophage, viruses that infect bacteria, are abundant in the human body but the relationship between the phageome and bacterial population dynamics is unclear. Because bacteriophage are often...

biorxiv.org
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Last day of #VoM2022. I had so much fun this week learning about other projects and connecting with other researchers in the field 👩🏻‍🔬
Image from popfaarun (@popfaarun)
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I had so much fun presenting my poster today! Thank you to everyone who came by #VoM2022
Image from popfaarun (@popfaarun)
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Are you interested in phage engineering? Come check out at poster in room 2! #VoM2022
Image from popfaarun (@popfaarun)
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Day 2 of Viruses of Microbes Conference 2022 #vom2022 very excited!!
Image from popfaarun (@popfaarun)
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