Postdoc in Stehbens lab @ UQ. Cytoskeleton, 3D migration & light switchable cell biology tools | she/her. Bluesky: https://teapaw.org/t.co/d21CbbFNQ0
Joined April 2019
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Pleased to share that the optogenetic microtubule severing tool #Optokatanin✂️ is now out in @CurrentBiology !!!
authors.elsevier.com/sd/arti…
Movie shows opto-katanin being used to locally sever microtubules in two locations (marked by blue boxes) inside a neuron.
Joyce Meiring retweeted
#Optogenetic and chemical genetic tools for rapid repositioning of #vimentin intermediate filaments, developed by Milena Pasolli, Joyce Meiring (@psychescope), Anna Akhmanova and colleagues: hubs.la/Q04B2kYB0
📕 From our #Tools collection: hubs.la/Q04B2lsn0
Excited to share that our latest story on #microtubule conformation controlling cell #signaling is now out in NCB! We show that microtubule expansion by taxane chemotherapeutics releases microtubule bound GEF-H1 which in turn activates RhoA/ROCK signaling. nature.com/articles/s41556-0…
Joyce Meiring retweeted
Two more recent preLights were written by Vibha Singh @SVibha1 🙌
One that discusses Taxane-induced conformational changes in the microtubule lattice. #preprint from Joyce Meiring (@psychescope) and colleagues @UniUtrecht.
#preLight ⬇️
prelights.biologists.com/hig…
Joyce Meiring retweeted
Taxane-Induced Conformational Changes in the Microtubule Lattice Activate GEF-H1-Dependent RhoA Signaling biorxiv.org/content/10.64898… #biorxiv_cellbio
Bored over the holidays? Give our new preprint on how #microtubule lattice alteration by taxols can regulate #RhoA #signalling via GEF-H1 a read!
Perhaps a new mechanism of action for taxol #chemotherapeutics during interphase.
biorxiv.org/content/10.64898…
Happy holidays ✨🎄
Radial microtubules in cyan, non-radial microtubules in yellow.
Biochemical tools to rapidly manipulate vimentin intermediate filaments by means of chemicals or light (optogenetics)
📷 Milena Pasolli & @psychescope et al Uni Utrecht, in @JCellBiol
➡️ bpod.org.uk/archive/2025/7/1…
Joyce Meiring retweeted
Pasolli, Meiring, Akhmanova et al. (Utrecht University) describe tools to acutely relocate #vimentin intermediate filaments by inducibly coupling them to microtubule motors. hubs.la/Q03wf_F20
@psychescope @gijsjekoenderi1
#Technology #Cytoskeleton
Excited to share that our fast & reversible chemical and optogenetic #vimentin pulling tools are now published in JCB! 🥳
doi.org/10.1083/jcb.20250400…
Hi! I was wondering if anyone has successfully cultured happy HEK293T cells in defined serum alternatives? If so what did you use?
Excited to share our new pre-print showcasing tools (chemical & optogenetic) for repositioning #vimentin in cells! Movie shows #ER (Halo-KDEL) sheets being relocalized together with vimentin (Vim) upon local vimentin pulling in U2OS. @gijsjekoenderi1
biorxiv.org/content/10.1101/…
Joyce Meiring retweeted
@ blue skies, there is
bsky.app/starter-pack/thorns…
a collection of 150 chemical biologist accounts to make it really easy to jump start your #ChemBio network.
Why not at Twitter? :( no wonder people are leaving here.
Please enjoy this movie of local #microtubule disassembly inside the yellow circle using #optokatanin (magenta) with ER labelled in cyan & please give me a follow on Bluesky! joycemeiri.bsky.social
Joyce Meiring retweeted
.@JagerLeanne, @psirez et al. @Bijvoet_Centre show that compacted and expanded microtubule lattice spacings coexist within cells and that #microtubules recognized by a marker for stable microtubules are predominantly expanded. hubs.la/Q02SXVbD0
I'll be talking about manipulating the cytoskeleton with #photopharmaceuticals and #optogenetic tools at this Monash Advanced Microscopy webinar. Anyone can join (if you are awake at 3pm AEST)!
Joyce Meiring retweeted
Caged Epothilones* now out in Angewandte: congrats Carina & all!
doi.org/10.1002/anie.2024101…
Stabilises #microtubule #cytoskeleton when and where you want. Does what you expect & nothing you don't
Giving it away for bio: just mail
*&more: see Fig S1!
@angew_chem @photopharma_lit
A very elegant study by some of my colleagues on decrypting lysosomal protein trafficking! They combine synchronised transport (using the RUSH system) with APEX proximity labelling to map out the lysosomal protein trafficking pathway in neurons. 👏🏼 #POTATOMap 🥔🗺️
It's out!😭🕺First preprint as a PhD at the Farias Lab @ginny_farias where we investigated biosynthetic lysosomal membrane protein trafficking, delivery and interactome with Protein Origin, Trafficking And Targeting to Organelle Mapping (POTATOMap)🥔
biorxiv.org/content/10.1101/…
Joyce Meiring retweeted
Nice example of actin retrograde flow in a gigantic lamellipodium. #cytoskeleton, #actin, #microscopy, #cell-motility, #science