Pasquale Valente (@pvalente) header
Pasquale Valente (@pvalente) profile picture

Padre, Marito, Medico, PhD. #haiku #cancerprevention #medicinalplants σπεῦδε βραδέως #personalized #natural #medicine #meditation #taichi #taijiquan

Roma
Joined September 2007
Photo by Pasquale Valente (@pvalente)Photo by Pasquale Valente (@pvalente)Photo by Pasquale Valente (@pvalente)Photo by Pasquale Valente (@pvalente)Photo by Pasquale Valente (@pvalente)Photo by Pasquale Valente (@pvalente)Photo by Pasquale Valente (@pvalente)Photo by Pasquale Valente (@pvalente)Photo by Pasquale Valente (@pvalente)Photo by Pasquale Valente (@pvalente)
Review su yerba mate (Ilex paraguariensis): dati preclinici positivi su peso, infiammazione e stress ossidativo. I pochi trial umani suggeriscono miglioramenti di BMI, glicemia e lipidi, ma l’evidenza resta insufficiente. Paper: mdpi.com/2223-7747/15/21/348…
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Weekly note (n.1) Senescent cells and the senescence-associated secretory phenotype (SASP) as a meeting point between the hallmarks of aging and cancer. Vanadyl, the mtDNA–cGAS–STING axis, and sirtuins all converge on the same molecular node.
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Il glioblastoma non è caotico: le cellule seguono una traiettoria spaziale prevedibile, da stati staminali periferici a stati ipossici centrali. L’atlante GBM-Space mappa oltre un milione di cellule da 12 pazienti. Paper: doi.org/10.1038/s41586-026-1…
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Le sirtuine (SIRT1–7) mappano su quasi tutti gli hallmarks dell’invecchiamento cutaneo: DNA, telomeri, mitocondri, infiammazione, autofagia. Il loro declino con età e UV accelera senescenza e perdita di matrice. Paper: doi.org/10.1111/acel.70789
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L’acido ursolico riduce i deficit cognitivi da neuroinfiammazione nei topi. Attenua stress ossidativo, attivazione gliale e ripristina la via BDNF-TrkB-CREB. Paper: pubmed.ncbi.nlm.nih.gov/4276…
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La disfunzione mitocondriale libera mtDNA che attiva cGAS-STING e amplifica la secrezione SASP. L’asse è proposto come bersaglio per senoterapici di nuova generazione. Paper: doi.org/10.1111/jcmm.71419
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La dieta chetogenica riduce la crescita tumorale elevando l’uridina prodotta dal batterio intestinale Flavonifractor plautii. L’uridina attiva cGAS-STING nel tumore e attenua l’infiammazione sistemica. Paper: nature.com/articles/s41467-0…
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Maggiore aderenza alla dieta mediterranea si associa a migliore cognizione, marcatori di invecchiamento più favorevoli e riduzione di IL-17/PCR. Non tutti gli outcome epigenetici sono uniformi: i risultati restano misti. Paper: doi.org/10.1093/nutrit/nuag1…
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Pasquale Valente retweeted
🧠 Scientists Found A Strange Way Brain Cancer Cells May Destroy Themselves Researchers discovered that combining certain antidepressants with blood thinners caused aggressive glioblastoma cells to “eat themselves” through a process called autophagy. This deadly brain cancer is extremely hard to treat, which makes the finding especially surprising. The research is still in early laboratory stages, but scientists believe this unexpected drug combination could open a new path in future cancer treatment. Sometimes the most powerful discoveries come from medicines already around us. Source: University of California, San Diego School of Medicine. Researchers discover antidepressant and blood thinner combination may trigger autophagy in glioblastoma cells.
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NEW EYE DROPS ARE CHANGING HOW WE TREAT AGE-RELATED BLURRY VISION! Have you noticed that reading small print or checking your phone becomes harder as you get older? The reason could be presbyopia, a natural age-related condition in which the eye's lens gradually loses its flexibility, making it difficult to focus on nearby objects. But there is an interesting development: prescription eye drops can now help improve near vision without immediately reaching for reading glasses. Several treatments have received FDA approval in the United States, including VIZZ and the newly approved presbyopia indication for RYZUMVI in October 2026. These drops work partly by making the pupil smaller, creating a pinhole-like effect that helps the eye focus on nearby objects. However, they don't reverse aging or restore the lens's original flexibility. Their effects are temporary, and they may cause side effects such as eye irritation or temporary changes in vision. Availability also varies by country, and these treatments require an eye-care professional's assessment. Could eye drops become an alternative to reading glasses for millions of people? Source: U.S. Food and Drug Administration. (2025–2026). Drug Trials Snapshots: VIZZ; RYZUMVI prescribing information.
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Pasquale Valente retweeted
fransa'da liselerden sokaklara,sendikalara taşan,genel greve ulaşan eylemliliğin sokak aralarında meşhur olan marşı: "iki tutkum var, bando ve devrim, yaşasın grev ve sabotaj, direniş alanlarımız ve kanunsuz eylemler iki tutkum var, omuz omuza olmak ve bir düşü birlikte kurmak"
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L’orchestre du nouveau monde joue Star Wars place de la République.
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🚨🇫🇷 INSOLITE | LA MANIFESTATION SE TRANSFORME EN CONCERT À PARIS ! 😂🎤 En pleine mobilisation du 5 novembre, les manifestants donnent de la voix pour dénoncer les salaires et la vie chère. La révolution se fait aussi en chanson ! 😭 #Jeudi5
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l’Orchestre du Nouveau Monde
🇫🇷🚨 #France : « I have two passions! » Festive atmosphere for the giant concert of the New World Orchestra on Place de la République in #Paris . #5Novembre
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Pasquale Valente retweeted
🥚 Two Eggs, Nine Essential Amino Acids: A Small Food With Powerful Benefits! What if two simple eggs could provide your body with nearly everything it needs to build and repair muscle? Eggs are one of nature's high-quality protein sources. Just one large egg contains approximately 6 grams of protein, while two provide around 12–13 grams. But here is what makes eggs special: they contain all nine essential amino acids your body cannot produce on its own. These tiny building blocks help repair tissues, maintain muscles and support important functions throughout the body. Eggs also provide valuable nutrients such as choline, vitamin B12, vitamin D and selenium, making them a nutritious addition to your daily meals. Sometimes, powerful nutrition comes in the simplest packages. Two eggs can make a meaningful contribution to your daily protein needs! Source: Harvard Health Publishing. (2024). Eggs, protein, and cholesterol: How to make eggs part of a heart-healthy diet. Harvard Medical School. Egg Farmers of Canada. (n.d.). Do eggs have complete protein?
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Antes de ser coronada como la "Suma Sacerdotisa del Soul", Nina Simone era una pianista clásica rigurosamente entrenada en Bach que tuvo que esconder su verdadero nombre para poder tocar en un club nocturno de Atlantic City. Le exigieron que cantara mientras acompañaba su propio piano, esa supuesta "música del diablo" que su familia desaprobaba, y en esa imposición nació una leyenda. "I Wish I Knew How It Would Feel to Be Free" no es solo un himno de derechos civiles; es el eco resonante de esa joven que, obligada a disfrazar su arte para sobrevivir, terminó transformando un modesto piano de cóctel en un púlpito de liberación absoluta. La verdadera genialidad de Simone descansa en la fusión alquímica de dos mundos que la sociedad insistía en mantener separados. Tomó la estructura matemática y solemne del barroco y la bañó con la crudeza visceral del blues, el jazz y el gospel.
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🚨 طفرة هندسية مجنونة: تشغيل نموذج Kimi K3 العملاق (2.78 تريليون بارامتر) على لابتوب بـ 8GB RAM فقط! 🤯💻 قام أحد المطورين بإنشاء المحرك بالكامل بلغة C الخالصة ليعمل على المعالج المركزي (CPU) وبذاكرة عشوائية لا تتجاوز 8 جيجابايت! المفاجأة؟ ليس إصداراً مصغراً أو مجتزأً.. بل هو نفس النموذج الكامل ونفس دقة المخرجات تماماً كما لو كان يعالج على جهاز خارق بـ 128GB RAM، لكن بسرعة أقل فقط! ⚡ كيف تم تحقيق الإنجاز البرمجي المرعب؟ • حجم الملف (Binary): الأداة بالكامل حجمها 176 كيلوبايت فقط! • صفر مكتبات خارجية: بدون PyTorch، بدون CUDA، وبدون أي كارت شاشة (No GPU). • تقنية البث: يعتمد على قراءة الأوزان (Weights) من القرص الصلب طبقةً تلو الأخرى (Layer by Layer)، مع الاحتفاظ بالحد الأدنى المطلق في الذاكرة. • الذاكرة تمنح السرعة فقط وليس السعة: على 8GB RAM يعطي سرعة ~26 ثانية لكل Token، بينما يرتفع لـ 5-6 ثوانٍ على 128GB. • كل ما تحتاجه: قرص SSD سريع بسعة ~1.7TB، وقليل من الصبر! التوافق شامل لكل المنظومات: Linux وmacOS وWindows (مع وضع Chat جاهز)! هذا الكود هو إثبات مرعب أن المستقبل لن يحتاج لشرائح كروت شاشة باهظة لتشغيل أعتى نماذج الذكاء الاصطناعي.. العبقرية البرمجية كفيلة بكسر كل القيود! 📌 احفظ التغريدة بمفضلتك لكي تعود للرابط🔖👇
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Replying to @heyshrutimishra
LLMs accumulate a lot of declarative knowledge. That's how they can answer a large number of questions. That's also why they require so many parameters and hence so much memory. But one can replace the accumulation of knowledge by *understanding* That what JEPA world models do. That's one reason they can be useful with considerably less memory and training data than LLMs. This paper merely shows that the underlying similarity structure of the data, whether text or image (e.g. co-occurence of words in text or objects in images) uniquely determines the shape of the representation point cloud, when the encoder is trained trained with a common anti-collapse criterion like SIGReg or VCReg (not by reconstruction).
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Pontormo (Jacopo da Pontormo) Visitazione, 1528-1532 olio su tavola.
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Pasquale Valente retweeted
Le decisioni che riguardano la vita umana, la libertà e l’uso della forza devono rimanere sempre soggette a un controllo umano efficace, informato e responsabile. Per questa ragione l’intelligenza artificiale deve essere “disarmata”, e incoraggio gli Stati che a novembre si incontreranno a Ginevra di compiere passi concreti verso il bando delle armi letali autonome.
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