@qianthefirst

Postdoc @GrothLab @NNFCPR @GarvanInstitute @ClarkEpiLab | DNA replication | Chromatin Replication | DNA methylation | 3D genome organisation

 Copenhagen
Joined December 2008
  • Tweets108
  • Following184
  • Followers156
1Media
This preprint is now published with some key additions guided by an excellent review process @NAR_Open. Also grateful to our collaborators for helping progress this one across the finish line! @suscla1 @qianthefirst @Yael_David__ @zhouwanding and others! academic.oup.com/nar/advance…

UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation

Abstract. The RING E3 ubiquitin ligase UHRF1 is an established cofactor for DNA methylation inheritance. The model posits that nucleosomal engagement throu

academic.oup.com
2
3
13
451
We are so grateful to @qianthefirst for this outstanding @NatureGenet News&Views piece highlighting our recent SPRINTER work and framing it so beautifully within the literature. A truly valuable resource! 🙏 Read it here👉 doi.org/10.1038/s41588-024-0… 🧵Dive into SPRINTER's work 👇
Simone Zaccaria@ZaccaSimo29 Nov 2024
🚨So proud to present the first study from our @CCG_UCL group together with @CharlesSwanton @NnennayaKanu and led by @ojlucas with key collaboration @Ward__Sophie and fundamental support @Rija_Zaidi_ @abi_bunkum & many others Out in @NatureGenet 👇 doi.org/10.1038/s41588-024-0… 🧵👇
3
11
977
🚨So proud to present the first study from our @CCG_UCL group together with @CharlesSwanton @NnennayaKanu and led by @ojlucas with key collaboration @Ward__Sophie and fundamental support @Rija_Zaidi_ @abi_bunkum & many others Out in @NatureGenet 👇 doi.org/10.1038/s41588-024-0… 🧵👇
6
39
7
158
26,125
Replying to @CprGoesGreen
@CPRGoesGreen created Green Labs, a guide with practical tips to make any lab or research space more sustainable. It’s a starting point to inspire everyone - students, management, and admin alike. @KabatnikSonja @labs_mann @UCPH_CPR Check it out: zenodo.org/records/14002138
8
17
2,336
We're hiring! We have a funded postdoc available and encourage anyone interested in epigenetics and/ or gametogenesis to apply. Experience in mouse genetics/ development especially welcome! Deadline: 1 October Apply here: jobportal.ku.dk/videnskabeli… Please retweet!
15
6
18
11,640
Honored to receive an ERC Advanced Grant to study the interaction of the chromatin landscape with 3D genome organization in Epigenetic Cell Memory 🎆 🍾 Very excited to start exploring these basic mechanisms that maintain cell identity across our lifespan 🤩 @GrothLab @UCPH_CPR
European Research Council (ERC)
@ERC_Research11 Apr 2024
📣 Good news today for 255 outstanding research leaders who have been offered ERC Advanced Grants. The new funding, worth nearly €652 million, is part of the 🇪🇺EU’s #HorizonEurope programme. Read more 👉 europa.eu/!TkwhWc #ERCAdG #FrontierResearch @EUScienceInnov
32
7
4
231
22,090
I am over the moon to announce that the Flury lab 🤩will open in May at the Max Planck Institute for Immunobiology and Epigenetics @mpi_ie in beautiful Freiburg!☀️⛰️ I am looking forward to meeting the colleagues @mpi_ie and @UniFreiburg and to exciting collaborations!
26
25
4
196
31,623
Just out in @NatureSMB! Our work on targeting the 3D epigenome to overcome endocrine resistance in ER+ #breastcancer. We discovered how epigenetic therapy-induced DNA methylation loss at enhancers impacts the 3D genome organization and gene regulation. nature.com/articles/s41594-0…

The potential of epigenetic therapy to target the 3D epigenome in endocrine-resistant breast cancer

Nature Structural & Molecular Biology - Here, the authors provide mechanistic insights into how decitabine-induced DNA hypomethylation can potentially overcome endocrine resistance in ER+...

nature.com
3
19
67
9,453
Last chance to apply for our #postdoc position! Deadline is Sunday!
Kathleen Stewart-Morgan@stewmorganlab18 Aug 2023
We are recruiting a postdoc for a fully funded position in our group in beautiful Copenhagen! We encourage anyone interested in #DNAmethylation and/or #Bioinformatics to apply. Deadline: 17 September Apply here: employment.ku.dk/faculty/?sh… Please retweet!
7
5
2,595
Super excited for #cshldnarep! Many amazing talks already. Looking forwards to the first poster session. If you're curious about DNA replication timing and epigenome replication, come see me at my poster tonight! #114, Biondi Hall. #cshl @cshlmeetings @GrothLab
7
811
CPR is a truly stellar place for science! Cutting edge technologies, blue skies and translational research, collaborative spirit.   Immensely sad that @novonordiskfond will close this scientific jewel. We will cherish the remaining time and #CPRlegacy 🏆
CPRatUCPH@UCPH_CPR17 Apr 2023
Despite our scientific success @novonordiskfond will close CPR due to new funding strategy. #forskpol #DKforsk We applaud our visionary leader Jiri Lukas for creating a global flagship in protein research whose pioneering spirit will live on #CPRlegacy. How did he do this? 👇🧵
11
1
64
10,455
An assembly pathway for making heterochromatin? Yes the DAXX histone chaperone promotes H3.3K9me3 prior to nucleosome assembly! @MolecularCell tinyurl.com/K9me3-SHHHH Great work by Carraro @massimocarraro7, Hammond @needfuzz and Hendriks! @thenielsenlab @GrothLab @UCPH_CPR
2
20
101
10,555
Loving the talks at #EMBOevoChromo! Enjoying my first in-person conference in a long time! But this is the view from the conference room. Not distracting at all haha 😅
6
Replying to @GarvanInstitute
Great working with Patrick Tan and Kazu Ushijima on our invited Science review on "Mapping genomic and epigenomic evolution in cancer ecosystems" out today science.org/doi/10.1126/scie… to celebrate the 20th anniversary of the Human Genome Project @suscla1, @AEpiA, @GarvanInstitute

Mapping genomic and epigenomic evolution in cancer ecosystems

science.org
1
7
17
Our lab's new paper out today @CellReports showing the effects of DNA methylation loss on 3D genome integrity. Happy to have contributed Hi-C data to this amazing research. Congratulations @qianthefirst and the team!
Qian_Du@qianthefirst22 Sep 2021
I’m excited to share our latest publication on the importance of #DNAmethylation in maintenance of DNA replication timing and 3D genome organization. Out in @CellReports today! @ClarkEpiLab @GarvanInstitute @suscla1 #epigenetics #3Dgenome cell.com/cell-reports/fullte…

DNA methylation is required to maintain both DNA replication timing precision and 3D genome...

Du et al. demonstrate the importance of DNA methylation in the maintenance of 3D genome regulation. They show that hypomethylation, a hallmark of cancer, is associated with the disruption of 3D...

cell.com
5
1
25
I’m excited to share our latest publication on the importance of #DNAmethylation in maintenance of DNA replication timing and 3D genome organization. Out in @CellReports today! @ClarkEpiLab @GarvanInstitute @suscla1 #epigenetics #3Dgenome cell.com/cell-reports/fullte…

DNA methylation is required to maintain both DNA replication timing precision and 3D genome...

Du et al. demonstrate the importance of DNA methylation in the maintenance of 3D genome regulation. They show that hypomethylation, a hallmark of cancer, is associated with the disruption of 3D...

cell.com
6
44
5
148
Truly grateful for all who have helped and collaborated along the way. @aachinger @Psy_Fer_ @DrLizCaldon @drjosephpowell @G_WCentre @martinalexsmith @c_stirzaker @kseskv A/Prof. Nicola Armstrong and the labs of Dr. Ira Deveson and Prof. Elgene Lim #AEpiA
8
Excited to see my work published today in @NatureComms! nature.com/articles/s41467-0… @ClarkEpiLab

Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically...

Nature Communications - The architectural protein CTCF is a mediator of chromatin conformation, but how CTCF binding to DNA is regulated remains poorly understood. Here the authors find that there...

nature.com
3
22
1
66
Excited to share our latest work, out today in @NatureComms We show that #3Dgenome interactions both within and between TADs frequently change in endocrine resistant breast cancer cells. @suscla1 @FaValdesMora @ClarkEpiLab @LizCal nature.com/articles/s41467-0…

Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in...

Nature Communications - Endocrine therapy resistance occurs often in estrogen receptor positive (ER+) breast cancer. Here, the authors find that 3D epigenome remodelling at ER-bound...

nature.com
2
13
3
37
Out in @CellCellPress yesterday, our latest work on #methylation encroachment into CpG island borders in #cancer. The dedicated efforts of @kseskv @c_stirzaker @suscla1 and all of our lab @GarvanInstitute come to fruition cell.com/cancer-cell/fulltex… …. xitter.cf/ClarkEpiLab/status/109…
22
2
43
Load more