Albert Recolons

So get this...a stranger DM'd me on X and offered to help design my backup cancer drug. For free! His name is Jan Domanski @jandom_random. He runs science at @open_fold, an open-source AI model that predicts how proteins and drugs physically fit together. My cancer is driven by one broken protein called ALK. Lorlatinib (the daily pill I take) jams itself into it and shuts it down. It's working. But resistance isn't an if, it's a when. The tumor mutates the pocket and the drug stops fitting. So Jan started modeling it on his own time, burning his own tokens. He ran AI models against ALK and lorlatinib, mapping where the known escape mutations land. And what did he find? Most of them hit right in the drug's pocket, swapping small pieces for bigger ones that physically block the drug. That's the good kind of bad news. A pocket problem is something you can design around. But the normal route to a new drug is ~2 years and ~$4-5M just to be ready for human testing. Jan's dream is getting a medicine to one patient in ~1 month. I'm not taking a homemade molecule while lorlatinib works. But if it ever fails....shit...I've got a guy! I started posting actively on X just a few weeks ago and it has brought me together with the most amazing, generous people!