rambabu retweeted
.@ANRFIndia hosted its 1st Meet & Greet webinar with 560+ #PMECRG awardees today. @shivkuma_k, @ponguru & the ANRF Media Team shared insights, inspiring young scientists to collaborate and democratize research.
@karandi65
@PrinSciAdvOff
@IndiaDST
rambabu retweeted
Our recent @ScienceMagazine article has been downloaded 24,806 times! So encouraging to see so much interest in our crowdsourced, open-science effort to find an accessible and affordable #COVID19 antiviral.
Here's the link in case you missed it ➡️scim.ag/4LB
rambabu retweeted
I was sorry to learn Nanosyn closed their SC site. We're looking for a new CRO to conduct in-vitro kinase activity assays. Any recommendations?
rambabu retweeted
A simple method for developing lysine targeted covalent protein reagents dlvr.it/SzkqzL
rambabu retweeted
Our latest paper now out @NatureComms
describing a simple bioconjugation approach to make covalent biologics that can target cysteines, but more importantly lysines! A thread 1/x nature.com/articles/s41467-0…
rambabu retweeted
📢 Results of the 2023 ERC Consolidator Grant competition are out.
€627 million for 308 researchers.
Who has been offered funding?
What topics and questions will they investigate?
Where will they conduct their research?
🇪🇺@HorizonEU #ERCCoG news 👉 europa.eu/!qvtkcH
rambabu retweeted
We’re proud to announce the talented researchers who have been awarded the @ERC_Research Grants for 2023!
Congratulations to Dr. Yonatan Stelzer of the Molecular Cell Biology Department, Prof. @Ariel_4321 of the Physics of Complex Systems Department, Prof. @michal_leskes of the Molecular Chemistry and Materials Science Department, and Prof. Nir London @london_lab of the Chemical and Structural Biology Department upon receiving the Consolidator Grant; and to Prof. Noam Sobel of the Brain Sciences Department, who was awarded the Synergy Grant
#ERCSyG
rambabu retweeted
Thrilled and grateful to receive an #ERCCoG award to make Covalent Proximity Inducers 🤩 Thank you @ERC_Research for the big vote of confidence. Special thanks to all of the colleagues and mentees who paved the way here. Positions available at all levels - feel free to email me
rambabu retweeted
Synthetic glues of FKBP12-mTOR pair by Deutscher, Meyner and co-workers (Hausch Group).
chemrxiv.org/engage/api-gate…
rambabu retweeted
Chemical #probes are important tools for validating drug targets. Covalent inhibitors & molecular degraders are expanding the druggable space. We now propose quality criteria for covalent & degrader probes: @ACSBioMed pubs.acs.org/doi/pdf/10.1021… @Chemical_probes @thesgconline #TPD
rambabu retweeted
Finally I read up on #DCAF1 based #PROTACs @NovartisScience. A recently disclosed non-covalent WD40-binding DCAF1 ligand enabled degradation of BRD9, Csk, Limk2, TEC, TNK2 & BTK. Hijacking essential DCAF1 may break resistance to CRBN PROTACs. @BioRxiv #TPD biorxiv.org/content/10.1101/…
rambabu retweeted
Israeli scientists in defence of democracy: chemistryworld.com/opinion/i…
rambabu retweeted
A new phd candidate...
teapaw.org/i/status/1622295103967…
rambabu retweeted
Interesting paper by the @london_lab in @J_A_C_S. They developed sulfamate acetamides as interesting new cysteine-directed electrophiles that allow development of covalent inhibitors as well as applications in covalent ligand-directed release (CoLDR). doi.org/10.1021/jacs.2c08853
rambabu retweeted
2. Sulfamates can be used for site-specific traceless labeling of proteins. We demonstrated labeling BTK C481 with modifications as small as a single methyl or propargyl. The labeling is concomitant with the elimination of the inhibitor, and the protein stays active. 10/n
rambabu retweeted
Special credit first - This is the final chapter in the CoLDR trilogy by @reddi78 who is the lead and co-corresponding author (pubs.acs.org/doi/10.1021/jac… ; pubs.acs.org/doi/10.1021/jac… ). A fantastic and original chemist who is now on the job market! Go get him! 2/n
rambabu retweeted
Paper alert 🚨 We report @J_A_C_S sulfamate acetamides as a new electrophilic “warhead” for late-stage optimization of covalent inhibitors and for covalent probes suitable for cells and in vivo administration. pubs.acs.org/doi/10.1021/jac…
A thread -> 1/n
