Biochemistry, molecular biology, and genetics researcher; Associate Professor of Biology; studying how ribosomes get where they need to be
Amherst, NY
Joined June 2015
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Dr. Sarah Walker retweeted
Vote like your life depends on it because this idiot will be in charge of your health.
Dr. Sarah Walker retweeted
BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
Dr. Sarah Walker retweeted
My lab has 2 postdoc positions funded by #NIH and #NSF to study novel ORFs and translational regulation in Arabidopsis and crops. Please retweet. jobs.plantae.org/jobs/205060…
Feeling very appreciative of the phenomenal postdocs in my lab past and present! Thank you Dalton, Houtan, Kris, and Kas for raising the bar in the lab and helping start and keep my research program going with your hard work, creativity and leadership!
Dr. Sarah Walker retweeted
Check out our lab’s latest paper on noncanonical translation initiation complexes! Beautiful structures Jacob and @haannguyen2 #structuralbiology #translation @Dunham_Lab jbc.org/article/S0021-9258(2…
New preprint on collaboration with Yu and Luo labs. There is a bioorthogonal click screen of Hmt1 substrates suggesting lots of factors in translational control are methylated by Hmt1 in yeast, and evidence that Arginine methylation of eIF1A NTT loosens start codon fidelity.
Protein Arginine Methylation of the Translation Initiation Factor eIF1A Increases Usage of a Near-cognate Start Codon biorxiv.org/cgi/content/shor… #biorxiv_molbio
We’re hiring at the postdoc level. If you know of people looking for a postdoc or research scientist position in molecular mechanisms of translational control, send them my way.
ubjobs.buffalo.edu/postings/…
WNY is a fun place to live for people with or without families. My favorite life things are the hiking and fun winter activities, amazing summer and fall, spring wildflowers, festivals, breweries and distilleries, without traffic and high housing costs of where I lived before.
Dr. Sarah Walker retweeted
Check out our latest: Using smFRET, we determine an entirely new mechanism for mRNA activation. As part of this work, we assign novel functions for each of the eIF4F components, including a 'hopping' activity of eIF4G and a 'strippase' activity of eIF4A. 🔬biorxiv.org/content/10.1101/…
Dr. Sarah Walker retweeted
BREAKING NEWS
The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
The Buffalo RNA Interest Group will be meeting again May 22 at 1 pm. Talks from @xuhang_liu from @RoswellPark on tRNA fragments in metastasis and Gable Wadsworth from @BanerjeeLab_UB on LLPS of RNA. Please reach out to Xuhang or myself if you’d like to be added to the list.
Dr. Sarah Walker retweeted
Now online! Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway dlvr.it/Sp9cbd
The Northeast Regional #Yeast meeting is happening again, organized by @gibney_lab @Cornell July 27-28. Looking forward to seeing some gorgeous gorges while we are there! blogs.cornell.edu/gibneylab/…
Dr. Sarah Walker retweeted
Using real-time imaging to watch human ribosomes decode mRNA, scientists find that the process is 10x slower in humans than in bacteria. Proofreading is the rate-limiting step. @TheBlanchardLab @ERundlet
ow.ly/9cUG50NEpmL
Dr. Sarah Walker retweeted
Cool RNA biochemistry. Drugs that inhibit 2′-O-methylation of the first nucleotide of mRNAs prevent cap snatching by influenza and inhibit viral replication. science.org/doi/10.1126/scie…
Dr. Sarah Walker retweeted
Our paper is now online 🙌 doi.org/10.1093/nar/gkad030
5'UTR purine-rich motifs deliver eIF4A1 unwinding activity site-specifically into repressive RNA structures of mRNAs encoding proliferative signatures. Well done all @CRUK_BI @CR_Horizons @ILikeHelicases @NAR_Open @RNASociety
Dr. Sarah Walker retweeted
Our paper on dormant egg ribosomes is out now! I couldn't be more grateful to work with @llorenzoorts,@PauliGroup @HaselbachLab and so many others. I learned so much and discovered my passion for #ribosomes nature.com/articles/s41586-0…
Thank you for your enthusiasm and support!
Dr. Sarah Walker retweeted
UB Graduate Students: Graduate Student Association Officer Candidate Petition Packets will be available at the end of January. The office of President, Vice President, and Treasurer will be filled through a general election. Each position comes w/ a stipend of $20,000. (1/2)