Niels J. Rupp, MD (@rupp_md) header
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Niels J. Rupp, MD

@rupp_md

Head & Neck, Oral & Maxillofacial and Genitourinary pathologist.

 Zurich, Switzerland
Joined February 2021
  • Tweets206
  • Following209
  • Followers418
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Photo by Niels J. Rupp, MD (@rupp_md)Photo by Niels J. Rupp, MD (@rupp_md)Photo by Niels J. Rupp, MD (@rupp_md)Photo by Niels J. Rupp, MD (@rupp_md)Photo by Niels J. Rupp, MD (@rupp_md)Photo by Niels J. Rupp, MD (@rupp_md)Photo by Niels J. Rupp, MD (@rupp_md)Photo by Niels J. Rupp, MD (@rupp_md)Photo by Niels J. Rupp, MD (@rupp_md)Photo by Niels J. Rupp, MD (@rupp_md)
(1) Thrilled and proud to present our validated salivary gland neoplasm specific NGS panel “SalvGlandDx”. #HNPath #ENTPath #cytology #cytopath #PathologyTweet ⬇️⬇️⬇️ authors.elsevier.com/sd/arti…
Image from Niels J. Rupp, MD (@rupp_md)
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Going beyond canonical MYB::NFIB and MYBL1::NFIB gene fusions ins adenoid cystic carcinoma #entpath #pathology Discovery of Novel TULP4/ACTN4/EWSR1/ACTB::MYB and... : The American Journal of Surgical Pathology journals.lww.com/ajsp/fullte…
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Niels J. Rupp, MD retweeted
IAOP (@IAOPath) profile picture
IAOP@IAOPath13 Aug 2024
The International Collaboration on Cancer Reporting (ICCR) has published the second edition of Head and Neck dataset. @iaopath is one of the contributors to the dataset! Please visit the ICCR website to access free datasets: iccr-cancer.org/datasets/pub… #oralpath #ENTPath #ICCR
Image from IAOP (@IAOPath)
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Check out our latest clinical, #histopathological and molecular study on #sinonasal #adenoidcystic carcinoma just published: nature.com/articles/s41598-0… #ENTpath #headandneck #molecular #pathology

Outcome-oriented clinicopathological reappraisal of sinonasal adenoid cystic carcinoma with broad...

Scientific Reports - Outcome-oriented clinicopathological reappraisal of sinonasal adenoid cystic carcinoma with broad morphological spectrum and high MYB::NFIB prevalence

nature.com
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Our cohort showed a high prevalence of MYB::NFIB gene fusion, which can also help to confirm diagnosis in cases with unusual morphology (such as the so-called metatypical AdCC).
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Many thanks to Tina Mauthe and all those involved for this close and excellent collaboration to study this rare tumor disease.
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Thrilled to share our latest paper on molecular imaging of prostate cancer: link.springer.com/article/10… Immunohistochemical ERG positivity is associated with decreased #PSMA expression and lower visibility in corresponding [68Ga]Ga-PSMA-11 #PET scans of primary #prostate cancer

Immunohistochemical ERG positivity is associated with decreased PSMA expression and lower visibil...

European Journal of Nuclear Medicine and Molecular Imaging - TMPRSS2:ERG gene fusion negatively regulates PSMA expression in prostate adenocarcinoma (PCa) cell lines. Therefore, immunohistochemical...

link.springer.com
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In concordance with our previous work, that IHC-PSMA negative areas are associated with decreased visibility on 68Ga-PSMA-11 PET scans, the IHC-ERG+ cases showed decreased visibility on corresponding PET scans.
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In addition, eight of nine cases, invisible on PET, showed IHC-ERG+, and an underlying TMPRSS2::ERG gene fusion by next generation sequencing.
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In our cohorts we identified a frequent molecular subgroup of primary prostate cancer, ERG+ by immunohistochemistry (IHC), which does show an increased heterogeneity of IHC-PSMA expression by IHC, and above all more IHC-PSMA negative areas.
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In addition, eight of nine cases, invisible on PET, showed IHC-ERG+, and an underlying TMPRSS2::ERG gene fusion by next generation sequencing.
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Check out our preliminary data on the performance of 18F-Choline #PET in non-FDG avid salivary gland carcinoma. #imaging doi.org/10.1186/s13550-024-0…
18 F-Choline-PET/CT for non-FDG-avid salivary gland cancer: a preliminary report

18 F-Choline-PET/CT for non-FDG-avid salivary gland cancer: a preliminary report

EJNMMI Research -

link.springer.com
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Whats your differential diagnosis on this tumor of the nasal cavity? #ENTpath #HNpath #pathology
Image from Niels J. Rupp, MD (@rupp_md)
Image from Niels J. Rupp, MD (@rupp_md)
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One can discuss morphological and molecular overlap with highly unusual epithelial-myoepithelial carcinoma of the sinonasal tract, but there are some arguments to favor a spectrum of LGSNAC. More to come soon!
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Excited to share our work on this type of tumor, just published @Histo_Journal. Expanding the spectrum of low‐grade sinonasal adenocarcinoma with biphasic seromucinous differentiation and activating HRAS/AKT1 mutations #ENTpath #pathology #openaccess 👉👉👉onlinelibrary.wiley.com/doi/…
Image from Niels J. Rupp, MD (@rupp_md)
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Niels J. Rupp, MD retweeted
Laetitia Collin (@CollinLaetitia2) profile picture
Laetitia Collin@CollinLaetitia224 Jun 2024
#ECC2024 Amazing French companion meeting on salivary glands FNA 😊many thanks to @DianaEstherossi Milan System v2 🙏🏻❤️ Monique Courtade-Saidi Niels J Rupp Voichita Suciu Claude Bigorgne and Jerzy Klijianienko
Image from Laetitia Collin (@CollinLaetitia2)
Image from Laetitia Collin (@CollinLaetitia2)
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