Julia Bleier (@sciblei) header
Julia Bleier (@sciblei) profile picture

Julia Bleier

@sciblei

PhD student @UCBerkeleyNeuro @IsacoffLab rapidly transitioning between FRETting & fretting states

 Berkeley, CA
Joined May 2015
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Photo by Julia Bleier (@sciblei)Photo by Julia Bleier (@sciblei)Photo by Julia Bleier (@sciblei)Photo by Julia Bleier (@sciblei)Photo by Julia Bleier (@sciblei)Photo by Julia Bleier (@sciblei)Photo by Julia Bleier (@sciblei)Photo by Julia Bleier (@sciblei)Photo by Julia Bleier (@sciblei)Photo by Julia Bleier (@sciblei)
We find that high open probability GluN2A receptors appear poised for activity with similar fully-liganded and apo-like conformations.
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In contrast, low open probability GluN2D (and to some extent GluN2C) receptors transit between two (likely inhibitory) regimes: splayed apo-like and super-compact agonist-bound conformations.
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Glutamate allosterically affects GluN1 conformation in a GluN2-dependent manner and we identify key structural regions which define differences in apo-like and glutamate bound conformations.
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We use single-molecule FRET to understand how GluN2 subunits influence the conformation of common GluN1 subunits across ligand conditions.
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Our measurements suggest that GluN2A, GluN2C, and GluN2D receptors occupy similar conformations with different ligand-dependent frequencies.
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The latest version of my PhD work @isacofflab characterizing conformational differences between functionally diverse NMDA receptor subtypes is online! cell.com/cell-reports/fullte…
Subtype-specific conformational landscape of NMDA receptor gating

Subtype-specific conformational landscape of NMDA receptor gating

Bleier et al. use single-molecule fluorescence resonance energy transfer (smFRET) in NMDA receptors to compare conformations and rearrangements of receptor subtypes with different GluN2 subunits....

cell.com
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Julia Bleier retweeted
Marqusee Lab (@MarquseeLab) profile picture
Marqusee Lab@MarquseeLab4 Mar 2024
Check out Naomi's paper examining domain coupling in mGlu receptors on bioRxiv! A fun collaboration with the @IsacoffLab and also featuring great work from our undergraduate researcher Sam! biorxiv.org/content/10.1101/…
Domain coupling in activation of a family C GPCR

Domain coupling in activation of a family C GPCR

The G protein–coupled metabotropic glutamate receptors form homodimers and heterodimers with highly diverse responses to glutamate and varying physiological function. The molecular basis for this...

biorxiv.org
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for those sticking around until Wednesday, hope to see you at my poster!
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going phoenix mode
Image from Julia Bleier (@sciblei)
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I can't wait to return to my research. (I will.) But it has been such a heartening experience to stand together on the picket line with fellow workers in departments across UC Berkeley to fight for contracts that will transform academia at the UCs and beyond. 1/5
Workers holding picket signs reading "UAW On Strike Unfair Labor Practice" march along a sidewalk with large buildings and construction across the street and a green lawn in the foreground

ALT Workers holding picket signs reading "UAW On Strike Unfair Labor Practice" march along a sidewalk with large buildings and construction across the street and a green lawn in the foreground

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Who are willing to face retaliation from faculty members who fail to see that we are not striking against them, but for the future of academia. It is in all of our interest to retain my striking colleagues, by pushing for good contracts and demanding the funding required. 5/5
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@sruuaw @uaw2865 @UAW5810
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Julia Bleier retweeted
UAW 4811 (@uaw_4811) profile picture
UAW 4811@uaw_481116 Nov 2022
At 5am this morning, striking Academic Workers formed a picket line at a construction site at UC Berkeley and successfully shut it down by talking to the workers from OE, IBEW, and LiUNA. They are honoring our picket line and won't be building today. #Solidarity #UAWonStrike
About two dozen people stand outside a construction site at dawn holding picket sines. Behind them in a chain link fence and some trees and building. The picket signs say UAW on strike unfair labor practice.

ALT About two dozen people stand outside a construction site at dawn holding picket sines. Behind them in a chain link fence and some trees and building. The picket signs say UAW on strike unfair labor practice.

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Thousands of UC Berkeley workers and community members are picketing all over campus for a fair contract! @sruuaw @uaw2865 @UAW5810
Image from East Bay DSA 🌹 (@DSAEastBay)
Image from East Bay DSA 🌹 (@DSAEastBay)
Image from East Bay DSA 🌹 (@DSAEastBay)
Image from East Bay DSA 🌹 (@DSAEastBay)
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Info for UC faculty on their right to respect a picket line in solidarity with @uaw2865 @sruuaw and @UAW5810
UC Faculty Assoc. (@uc_faculty) profile pictureUC Faculty Assoc.@uc_faculty7 Nov 2022
Our answers to Senate Faculty frequently asked question about what can do around the UAW strike. #FairUCNow cucfa.org/2022/11/faqs-for-s…
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Julia Bleier retweeted
David Kern (@kerndm) profile picture
David Kern@kerndm2 Aug 2022
I once thought of ion channels as protein tunnels, built to exclude the membrane. Fitting that the one @stevebrohawn and I chose to study contains internal lipids central to channel function. Preprint on the LRRC8A:C volume-regulated anion channel: doi.org/10.1101/2022.07.31.5…
Image from David Kern (@kerndm)
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