Science enthusiastic. Mom of two. Scientist at the Institute of Nano Science and Technology.
Mohali
Joined November 2015
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We report self-assembled bacterial shell proteins that act as stable biological semiconductors, generating strong photocurrents without external bias pubs.rsc.org/en/content/arti…
#ChemicalScience #Bioelectronics #ProteinEngineering @Silkybedi2 @smrose_24 @INSTMohali
INST Mohali Hiring PhD students (inst.ac.in/careers). Open positions at the Sinhalab. Do write to us ([email protected]) if you are "Dreamers who pipette with a purpose"! @INSTMohali
Excited to share our latest work from the Sinha Lab @ INST Mohali, together with Dr. Deepak Sharma @ IMTECH Chandigarh, just published in Nanoscale!
We developed charge-sensitive gold nanoclusters to distinguish α-Syn aggregates, a key step toward early Parkinson’s detection.
ALT What if tiny gold clusters could spot the bad guys in Parkinson’s? We made charge-sensitive gold nanoclusters that glow differently when they meet α-synuclein oligomers vs fibrils. No labels. No tricks. Just pure nano-smarts. https://doi.org/10.1039/D5NR00887E
Our findings:
These nanoclusters show distinct signals based on the type of α-synuclein aggregate they encounter—enabling label-free detection and discrimination.
This work brings us closer to biosensing tools for neurodegenerative diseases.
Grateful to my team and Dr. Deepak Sharma's lab for a fantastic collaboration!
Read the paper: pubs.rsc.org/en/Content/Arti…
@sinhalabinst @INSTMohali
Join the Sinha Lab at INST Mohali 🧬
Research on biomolecular self-assembly, synthetic biology, and disease mechanisms.
📩 Apply: sinhas[at]inst[dot]ac[dot]in
🔗 More info: inst.ac.in/scientist/24-shar…; inst.ac.in/careers
#PhDPosition #SyntheticBiology #Biophysics
Silky just defended her thesis today! From BMC proteins to bioelectronics wizardry, she's been assembling more than just molecules. Go Dr. Silky!
Dr Asifkhan Shanavas and Dr. Surajit Karmakar along with Dr. Kausik Chakraborty (IGIB) served the committee @Silkybedi2 @INSTMohali
Sharmistha Sinha retweeted
Our lab at @INSTMohali will be hiring a Ph.D. student in the upcoming August session. If you are interested in working with us, consider applying for the same.
If you would like to know more about our research, please check out our personal group website.
amitmondal23.wixsite.com/my-…
Sharmistha Sinha retweeted
INST Mohali celebrated its Foundation day on 25th March 2025. Professor Laxmidhar Behera, Director, IIT Mandi, delivered a Foundation Day lecture on the topic “History of AI and Some Selected Applications”. The winners of the Sport Day-2025 meet have also been felicitated.
🔬 Love molecular self-assembly? 🧩 Sinha Lab @ INST Mohali is decoding bacterial microcompartments for synthetic biology & disease research! Got a CSIR/UGC-JRF? Join us! ✉️ sinhas[at]inst.ac.in
More: inst.ac.in/scientist/24-shar… #PhD #Biophysics #Nanoscience
Sharmistha Sinha retweeted
Breaking up translation condensates in cancer: nature.com/articles/s41556-0…
Sharmistha Sinha retweeted
Latest lab review- The Gut microbiota-Immune-Brain axis: Therapeutic Implications. Just out in @CellRepMed Well done @kjdoriordan @gerrymoloney @LilyKeane & @UCCpsychiatry
cell.com/cell-reports-medici…
Sharmistha Sinha retweeted
A globular protein exhibits rare phase behavior and forms chemically regulated orthogonal condensates in cells: nature.com/articles/s41467-0…
Genes That Stick Together, Work Together!
A molecular life lesson: teamwork and proximity shape success! In nature, who you’re next to matters! Check our latest publication to learn more! doi.org/10.1016/j.bbagen.202… @INSTMohali @Silkybedi2 @smrose_24
ALT Subcellular life isn’t just chaos—it’s strategic assembly! The pdu operon in Salmonella shows us that gene order follows the rules of molecular matchmaking—strong protein-protein interactions keep gene neighbors close, streamlining microcompartment construction. Tight bonds? Organized nanostructures! Lesson learned: Nature optimizes for efficiency, even at the genetic level! Check out our latest publication for the full story.
Aarcha presenting "Harnessing the Disorder" to design synthetic bioanoreactors at the Indian Biophysical Society Meeting 2025. #IBS2025 @INSTMohali @sinhalabinst
Bile acids stirring the pot in Parkinson’s? Lithocholic acid (LCA) speeds up α-synuclein clumping by 75%, while deoxycholic acid (DCA) takes a 30% nudge. Together, they’re not exactly brain-friendly!
Check out our recent findings at doi.org/10.1021/acschemneuro… @INSTMohali @IndiaDST
