Sam Hulse (@svhulse) profile picture

Theoretical Evolutionary Biologist, Postdoc in the Bruns Lab at UMD

Joined August 2021
Photo by Sam Hulse (@svhulse)Photo by Sam Hulse (@svhulse)Photo by Sam Hulse (@svhulse)Photo by Sam Hulse (@svhulse)
Our new preprint is out! We use stochastic genotype landscapes to predict the shape of evolutionary trade-off functions, and test what happens when you use this as the basis of a mutation-selection model.
The Emergence of Non-Linear Evolutionary Trade-offs and the Maintenance of Genetic Polymorphisms biorxiv.org/cgi/content/shor… #biorxiv_evobio
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Our new paper on host-pathogen coevolution and spillover (as seen at EEID and Evolution) just came out in evolution letters! 1/ academic.oup.com/evlett/adva…
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However, there is a catch! When the loci underlying general and specific resistance become linked, this positively correlated resistance transitivity can switch to negative. When we let linkage evolve, tight linkage between general and specific resistance is favored. 5/
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Having negative resistance transitivity means that a host population maintains individuals which are more susceptible to foreign pathogens than endemic, opening an ecological niche for spillover pathogens to invade. 6/
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