@tham_lab

🇲🇾 scientist in 🇦🇺 | 🦟 🩸 #malaria |🦙 #nanobodies | Prof @WEHI_research @ourANU | on Wurundjeri, Ngunnawal & Ngambri lands | views my own 🏃🏻‍♀️ 🍜

wehi.edu.au/people/wai-hong-tham
Joined May 2018
  • Tweets14.4K
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We are making antibody cocktails against #COVID19 !! 🙏 #MRFF funding to manufacture monoclonal antibody treatments into clinical trials. Great collaborative outcomes between @WEHI_research @TheDohertyInst @BurnetInstitute @KirbyInstitute @CSL AffinityBio and @CSIRO
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Wai-Hong Tham retweeted
Sleebs Lab@Sleebs_LabJun 16
Want to know which plasmepsins are the most promising targets of the next generation of antimalarials. Find out in the recently published review by @Sleebs_Lab @WEHI_research doi.org/10.1002/med.70065
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Nanobodies against Plasmodium adhesins that block receptor engagement and malaria parasite invasion Work led by @JaisonDSa1 & Jill Chmielewski on PfRh5, PfRh4 and PvRBP2b nanobodies @WEHI_research Please share widely and feedback welcome! biorxiv.org/content/10.64898…
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We just opened 5 junior group leader positions at the Ignaz Semmelweis Institute in Vienna. We are looking for motivated, enthusiastic young leaders in infectious disease research that complement our current team. More information here: semmelweisinstitute.ac.at/tr…

Training & Career - the Ignaz Semmelweis Institute

Training We are committed to train the next generation of basic and translational infectious disease researchers. We believe, young people full of energy and creative ideas can solve problems that we...

semmelweisinstitute.ac.at
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Wai-Hong Tham retweeted
Sleebs Lab@Sleebs_Lab11 Dec 2025
Pleased @Sleebs_Lab contributed a small role in remarkable team led by Paola Favuzza and Alan Cowman @WEHI_research and David Olsen and John McCauley at MSD that developed MK-7602 now in clinical development for the treatment of malaria. thelancet.com/journals/ebiom…
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Australia's research capability is set for a major boost, with 8 new ARC Centres of Excellence receiving $279M. From quantum computing and ocean health to renewable fuels and social inclusion, these Centres will unite leading researchers to tackle critical challenges: arc.gov.au/news-publications…
Light blue graphic with a stylised ribbon and medal icon in the centre, surrounded by small decorative sparkles and lines. Below, a dark blue banner reads “ARC Grants”, with the text “ARC Centres of Excellence announcement” underneath.

ALT Light blue graphic with a stylised ribbon and medal icon in the centre, surrounded by small decorative sparkles and lines. Below, a dark blue banner reads “ARC Grants”, with the text “ARC Centres of Excellence announcement” underneath.

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Tomorrow (Tues 9 Dec) we will be announcing the outcomes of ARC Centres of Excellence 2026 (CE26). Stay tuned for an update.
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I’ve been working with BoltzGen lately and decided to put down a short breakdown from a biologist's perspective. Full blog link in the comments
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HAP2 is an ancient fusogen and used by malaria parasites for gamete fusion during fertilisation 🦟 Check out our preprint on P. falciparum HAP2 - crystal structure of domain 3 + nanobodies 🦙💎 still so much to discover about this fascinating protein 🥚 biorxiv.org/content/10.64898…

Crystal structure and nanobodies against domain 3 of the malaria parasite fusogen Plasmodium...

Malaria parasites are transmitted to humans through a bite from an infected female Anopheles mosquito. Within the mosquito midgut, malaria parasite gametes are activated and undergo fertilisation. If...

biorxiv.org
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Introducing Dr Jaison D Sa @JaisonDSa1 who was awarded his PhD from University of Melbourne 🎉🎉 Co-supervised by Phillip Pymm & me 🩸Stabilized vivax antigen for serodiagnostics 🧬 Alpseq open source nanobody discovery 🦙Nanobodies to Plasmodium adhesins – watch this space!
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Keen to use an open source workflow for nanobody discovery? Check out Alpseq 🦙 Alpseq’s diversity analysis, enrichment counts & clustering allow different approaches for nanobody selection Great collab @QGouil & Kathleen Zeglinski @WEHI_research biorxiv.org/content/10.1101/…

alpseq: an open-source workflow to turbocharge nanobody discovery with high-throughput sequencing

Nanobodies have emerged as promising tools for many biotechnological applications due to their small size, high stability, and remarkable binding specificity. Next-Generation Sequencing (NGS) enables...

biorxiv.org
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Incredibly proud to share that our work on Cryptosporidium Oocyst Wall Proteins is published in @PLOSPathogens journals.plos.org/plospathog… Led by previous PhD student @BacchettiRoss and carried on by current PhD student, Sarah Stevens.

Cryptosporidium oocyst wall proteins are true components of the oocyst wall and COWP8 is not...

Author summary Infection with Cryptosporidium causes diarrhoea, which can be fatal for malnourished children or people who are immunocompromised. There is no vaccine or effective medicines available...

journals.plos.org
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Wai-Hong Tham retweeted
Chi-Min Ho@mimi1inh20 Oct 2025
Learn how our hunt for the native structure of top #antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms 👉 rdcu.be/eLRlH 🦠🔬❄️ A team effort by @mehsehret @cmholab & Anurag Shukla @AkhilVaidya1 #cryoEM
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Wai-Hong Tham retweeted
Brian Hie
@BrianHie24 Sep 2025
Today, we report Germinal, a method for efficient de novo antibody design, with @santimillef and @SynBioGaoLab. Germinal achieves success rates of 4-22% across diverse epitopes. We make the work fully open, without doing lame things like posting a preprint without methods. 🧵
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Wai-Hong Tham retweeted
Jason Sheltzer@JSheltzer23 Sep 2025
In two weeks, the 2025 Nobel Prizes will be announced. Based on looking at other pre-Nobel “predictor” prizes, I think that these 36 scientists are the most likely candidates:
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Delighted to talk about blocking malaria transmission at Director’s Seminar @JCSMR 🦟🦟🦟 Fun to discuss cryo-EM structures, nanobodies, new bispecifics and mRNA vaccines that block transmission🔬 💉 💎 🙏@MeganOutram91 for taking the first ever photo where you can see me 😂
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Step inside the world of discovery, where imagination and creativity collide, with our online gallery #ArtofScience. View 16 extraordinary images captured by WEHI scientists working to solve urgent health challenges. See the exhibition: wehi.edu.au/art-of-science/?…
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Wai-Hong Tham retweeted
Matt Higgins@ParasiteMatt15 Sep 2025
Delighted to share our review on how those malaria parasites get into our blood cells and how we might stop them. rdcu.be/eGnUl
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Frankie Lyons PhD Completion Seminar 💕 She worked on key fertilisation antigens for malaria parasites - Pfs48/45 and PfHAP2 - developing nanobodies, bispecifics & mRNA vaccines to block malaria transmission 🦟 @WEHI_research 🌱 Lab support wearing her favourite moss green
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🎓 Applications are now open for WEHI’s International PhD Scholar Initiative. 📅 Apply by Sunday 26 October 2025 🔗 Learn more about eligibility, scholarships and how to apply: wehi.edu.au/education/phd/in… Help us spread the word by sharing with your networks!
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Like to take 12–24 months of fully supported research in Japan? Early-career Australian researchers can apply for the 2026–27 JSPS Postdoctoral Fellowships to undertake 12–24 months of collaborative research in Japan. This prestigious program offers generous support, including airfares, a monthly stipend, a settling-in allowance, and overseas travel insurance. 📆 Apply by Thursday 2 October, 2025 🔗 Learn more and apply: science.org.au/supporting-sc…
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