lead developer of #Kaptive + bonafide #Klebsiella nerd; post-doc @AlfredMonash_ID | PhD @UoE_IM | BSAC+NGS @UKHSA; triathlon + music production in another life
Melbourne
Joined September 2018
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Tom Stanton retweeted
How can we use genomics to help guide new vaccines and control strategies for #klebsiella?
Check out this article to see how we are contributing- for me it's undoubtedly one of the most rewarding things we do!
With @DrKatHolt
@tomstantonmicro @theycallmemaggi + many others
Imagine carrying a baby to term only to lose it within four weeks to a severe bloodstream infection.
Every year, 1 million newborns (est) die of neonatal sepsis.
The most common cause is Klebsiella pneumoniae bacteria, which also afflict countless elderly and immunocompromised adults in hospital settings, causing pneumonia and blood and urinary tract infections.
Infectious Diseases researcher Prof Kelly Wyres @MonashSTM and @CentreImpactAMR is part of an international team led by @LSHTM, laying the groundwork for a vaccine that would target pregnant women, generating antibodies that would cross the placenta, protecting babies after they're born.
The @gatesfoundation is funding their work to support global genomic surveillance efforts, tracing different strains and infection patterns of K. pneumoniae and other bacteria that cause neonatal sepsis. Read more in Monash Lens.
#Monash #TranslationalMedicine #AMR #MaternalHealth #Superbugs #Sepsis
lens.monash.edu/@kelly-wyres…
Late to the party but I finally got Blue sky, follow me!
bsky.app/profile/tomstantonm…
Tom Stanton retweeted
Here we go! #KLEBS2024
400 in person and 400 online participants from 71 countries.... Wow!
Tom Stanton retweeted
For those considering migrating to that better place, @KlebClub can ease your transition & help connect with the community.
Leave us your 🔵🦋 handle and we’ll add you to the #Klebsiella starter pack.
If u r going to #KLEBS2024 in Paris, we’ll have a QR code to join easily.
Tom Stanton retweeted
1/ One of the most common mistakes in bioinformatics is the one-off error. If you are not careful, you will make mistakes. Even experienced bioinformaticians are not aware of it and the mistake prevails in many bioinformatics tools. A thread 🧵
Tom Stanton retweeted
Three weeks to go to get your abstracts in for MGE AUS
- A meeting dedicated to Mobile Genetic Elements!
- Student/ECR focused
- Travel sponsorships available
- Keynote speakers announced
- Two day program coming soon
Register today!
mgeaus.org
@AUSSOCMIC
Tom Stanton retweeted
A reminder to submit your abstracts for MGE AUS by November 29th
- Student/ECR focused
- Travel sponsorships available
- Keynote speakers announced
- Two day program coming soon
- Early bird prices still available
mgeaus.org
@AUSSOCMIC
Tom Stanton retweeted
The exopolysaccharide Poly-N-Acetyl-Glucosamine (PNAG) coats Klebsiella pneumoniae in vivo dlvr.it/TDc8T5
Dear Kaptive-Web users, we are currently, migrating over to #Kaptive 3 (woo!); the server will be back up and running ASAP 🧑💻
In the mean time, head on over to our shiny new docs 👇
kaptive.readthedocs.io/en/la…
Tom Stanton retweeted
(1/6) Our new short preprint, led by @helena_bethanyy and myself on incidental bacterial domestication between patient isolation and creation of frozen stock. Geno/phenotype changes are obscured by rich media and more prevalent than we previously thought
biorxiv.org/content/10.1101/…
Tom Stanton retweeted
Excited to share this preprint where we’ve used genomic analysis of >3000 genomes to study Klebsiella pneumoniae in a One Health perspective 🦠🔬👩💻#OneHealth #KLEBGAP #KlebClub @IrenLohr @DrKatHolt @NORKLEBNET
A genome-wide One Health study of Klebsiella pneumoniae in Norway reveals overlapping populations but few recent transmission events ... biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Tom Stanton retweeted
Really important data on determinants of hypervirulence in #klebsiella from Tom Russo and colleagues: tinyurl.com/5h9d457k
Highlights complexity of the hv pathotype and shows the impact of aerobactin varies by strain.
Check out our commentary below.
@KlebClub
Comment from @KelWyres and myself on new experimental data (from Tom Russo and colleagues) and how we define #hypervirulent #Klebsiella pneumoniae genetically across diverse lineages.
thelancet.com/journals/ebiom…
Comment from @KelWyres and myself on new experimental data (from Tom Russo and colleagues) and how we define #hypervirulent #Klebsiella pneumoniae genetically across diverse lineages.
thelancet.com/journals/ebiom…
Tom Stanton retweeted
@tomstantonmicro doing a fab job presenting Kaptive 3 for the first time, at #asm2024
Increased sensitivity ✅
Increased accuracy ✅
Increased speed ✅
You can check it out here: github.com/klebgenomics/Kapt…
"Ah you think darkness is your ally? You merely adopted the dark. I was born in it..."
#KlebClub planning is back in session with our TWO NEW MEMBERS!!! Make sure to send a big congrats to Juan Valencia and @tomstantonmicro!!
My friend and colleague @bananabenana has released this fantastic culmination of years of work, unpicking the species-wide metabolome of #Klebsiella.
A wonderful pairing of lab and computational biology, check out the preprint asap!
Ever wondered why there are so many co-circulating #klebsiella pneumo clones? ... me too!
So I'm thrilled to present this new preprint from my lab, where we explore this very question. The culmination of 3+ yrs hard work by @bananabenana!
doi.org/10.1101/2024.07.24.6…
@KlebClub
