Mitochondrial ATP promotes T cell differentiation through chromatin accessibility #mitochondria #immunometabolism share.google/opdKGFCs3cFB3es…

🚨 We’re hiring a postdoctoral research associate! 🚨 The Ryan Lab at Trinity College Dublin is recruiting a Postdoctoral Research Associate to join our new team in the School of Biochemistry and Immunology, based in the Trinity Biomedical Sciences Institute for 2026/2027. This is a great opportunity for scientists with a PhD interested in mitochondrial biology, immunology, inflammation, infection, metabolism, or primary mitochondrial disease. The position will be available for 2 years in the first instance with the potential for extension. The role will aim to understand how pathogenic mitochondrial DNA mutations reshape the innate immune response to infection ex vivo and in vivo. The successful candidate will contribute to a programme involving: 🧫 Primary macrophage culture 🐭Mouse model-linked infection studies 🔥 Inflammatory and infection-associated assays 📊 Cytokine, metabolic, and immunological readouts 🧬 Molecular biology and genotyping 🔬 A growing programme in mitochondrial immunometabolism 📍 Location: Trinity Biomedical Sciences Institute, Trinity College Dublin 📅 Anticipated start: Flexible, ideally November 2026-January 2027 ⏰ Closing date: 12 noon, 07 October 2026 Please share widely and do get in touch if you think you might be a great fit! To apply: Applicants should submit a full CV plus a short cover letter to include the names and contact details of 2 referees (including email addresses), to:- Dr. Dylan Ryan [email protected] Please use the subject line: Postdoctoral Research Fellow Application – Ryan Lab. Important: Applications by private Social Media messages will not be considered and will not be responded to. Only applicants invited to interview will hear back from us.

Very excited to announce that the first paper from the lab is now live @NatureComms #mitochondria #immunometabolism This work was led by postdoc @EloiseMLMrqs with many important contributions from all of our co-authors. New insights since the preprint (summarised below): 1) Biphasic IFN-I expression 2) Late phase IFN-I is mediated by mitochondrial nucleic acid signalling incl. cGAS-STING pathway 3) Reduced IL-1 and COX2 is mediated in part by autocrine IFN-I 4) Systemic IFN-I signalling in different tissues, notably the kidney, in vivo Please check it out! nature.com/articles/s41467-0…