@trsheph

biopolymer engineer, synthetic biologist. [email protected]

Joined August 2013
  • Tweets306
  • Following351
  • Followers127
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Moving to Mastodon, see you all over there [email protected]
Our favorite design "recipes" built on the Onyx can provide great insights into all kinds of fun biochemistry: inscripta.com/blog/your-favo…
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Have you ever wondered about the limits of the ribosome's ancient bond forming mechanism? Beyond polypeptides/polyesters, what else is possible? Now @NatureComms, @NUSynBio show that the ribosome can make pyridazinone bonds via cyclocondensation reactions nature.com/articles/s41467-0…

Ribosome-mediated biosynthesis of pyridazinone oligomers in vitro

Nature Communications - Ribosomes have evolved to polymerize L-α-amino acids into proteins comprising a peptide backbone. Here, a pyridazinone backbone is formed using ribosomes in vitro,...

nature.com
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Groundbreaking News! Andrew Horwitz, VP of Research and Development, Sestina Bio, LLC. explains how Inscripta’s #Onyx platform helped accelerate their goals to produce a #sustainable #biomanufacturing process for Bakuchiol! inscripta.com/news/sestina-b…
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I'm delighted to share the first paper from my PhD published in @ACSSynBio! SpyPhage: A Cell-Free TXTL Platform for Rapid Engineering of Targeted Phage Therapies. doi.org/10.1021/acssynbio.2c… #TXTL #phage #phagetherapy #synbio #cellfree

SpyPhage: A Cell-Free TXTL Platform for Rapid Engineering of Targeted Phage Therapies

Abstract. The past decade has seen the emergence of multidrug resistant pathogens as a leading cause of death worldwide, reigniting interest in the field o

pubs.acs.org
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Glad to share our new result " cryo-EM structures of human m6A writer complexes ". doi.org/10.1038/s41422-022-0… or as a PDF here nature.com/articles/s41422-0….

Cryo-EM structures of human m6A writer complexes

Cell Research - Cryo-EM structures of human m6A writer complexes

nature.com
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Engineered Spore-Forming Bacillus as a Microbial Vessel for Long-Term DNA Data Storage doi.org/10.1021/acssynbio.2c…
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Tyson Shepherd retweeted
Ars Technica
@arstechnica15 Sep 2022
The potentials of DNA functioning as long-term archival storage are massive, but efforts to make it a reality mostly stayed in the research community—though that's starting to change. trib.al/FAiSaBk

Why are hard drive companies investing in DNA data storage?

DNA may enable computation in storage on massive data sets.

arstechnica.com
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Yesterday, the Biden-Harris Administration announced funding of more than $2 billion to advance @POTUS' Executive Order on a National Biotechnology and Biomanufacturing Initiative to create good jobs, reduce carbon emissions, and foster health. More: ⤵️ whitehouse.gov/briefing-room…
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Exciting for Inscripta to join other industry leaders today at The White House Summit on #Biotechnology and #Biomanufacturing for the American #Bioeconomy. Just the beginning… whitehouse.gov/briefing-room…
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Thrilled to represent #biotech at the @WhiteHouse today with our good friends @jrkelly (@Ginkgo), Douglas Friedman (@TheBioMADE), Tia Lyles-Williams (@LucasPyeBIO), Sri Kosaraju (@InscriptaInc), @meganjpalmer (@Stanford) and Barbara McQuiston.
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Today we share "mobilization" for engineering translation systems @ACSSynBio Sam Gowland @NUSynBio sampled large genomic space to evolve genomically integrated tethered ribosomes that support increased growth phenotypes #synbio pubs.acs.org/doi/full/10.102…

Mobile Translation Systems Generate Genomically Engineered Escherichia coli Cells with Improved...

Abstract. Cellular translation is responsible for the synthesis of proteins, a highly diverse class of macromolecules that form the basis of biological fun

pubs.acs.org
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DNA Origami Presenting the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune Response biorxiv.org/content/10.1101/…

DNA Origami Presenting the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune...

Effective and safe vaccines are invaluable tools in the arsenal to fight infectious diseases. The rapid spreading of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible of the...

biorxiv.org
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Efforts to repurpose ribosomes could lead to new antibiotics, materials, and flexible electronics. Check out our new work by @__dskim @amw_stanford @RDasLab @NUSynBio in @nchembio to engineer tethered ribosomes. Story by @NorthwesternEng @NorthwesternU mccormick.northwestern.edu/n…

Artificial Ribosome Continues Advancing

Researchers created a new version of Ribo-T that provides a foundation to propel broad, new efforts in the synthesis and evolution of non-biological polymers made from engineered tethered ribosomes.

mccormick.northwestern.edu
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Therapeutic Inhibition of Staphylococcus aureus ArlRS Two-Component Regulatory System Blocks Virulence pubmed.ncbi.nlm.nih.gov/3573…

Therapeutic Inhibition of Staphylococcus aureus ArlRS Two-Component Regulatory System Blocks...

Staphylococcus aureus is a common cause of severe infections, and its widespread antibiotic resistance necessitates search for alternative therapies, such as inhibition of virulence. As S. aureus...

pubmed.ncbi.nlm.nih.gov
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Tyson Shepherd retweeted
Ian James@ByIanJames15 Jun 2022
The surface of Lake Mead, the country's largest reservoir, is now at 1,045 feet above sea level. Below about 895 feet, water would no longer pass through Hoover Dam. "We are 150 feet from 25 million Americans losing access to the Colorado River." latimes.com/environment/stor…

Major water cutbacks loom as shrinking Colorado River nears 'moment of reckoning'

As the Colorado River water shortage worsens, major cutbacks are needed to reduce most perilous risks, a federal official tells senators.

latimes.com
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Really excited about our @nusynbio new manuscript published in @NatureComms with @MichaelKoepke80 @LanzaTech @GonzalezLabUSF @ENERGY This work forms a new blueprint for carbon-negative manufacturing with #synbio mccormick.northwestern.edu/n…

Closing Gaps to Find New Energy Sources

A multi-institutional research team including Professor Michael Jewett implemented a new process to produce butanol, butanoic acid, hexanol, and hexanoic acid, which could make green energy easier to...

mccormick.northwestern.edu
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Tyson Shepherd retweeted
Lynne Dieckman@DieckmanLab28 Apr 2022
Looking for a full-time research technician to join my protein biochemistry lab at Creighton University. Please spread the word to anyone who may be interested!
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Riboswitch-inspired toehold riboregulators for gene regulation in Escherichia coli doi.org/10.1093/nar/gkac275
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Tyson Shepherd retweeted
Kevin Costa@scitechkevin14 Apr 2022
We may never understand all of biology's rules, and the possibilities are greater than all the stars in the universe. Companies like @InscriptaInc and @InfinomeBio enable bioinnovators to operate over nature's vast diversity — at incredible speed. #builtwithbiology
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