Abstract Biologist. Data addict. Postdoc on brain organoids @Knoblich_lab. PhD in single-cell genomics at the van Oudenaarden lab.
Vienna, Austria
Joined March 2017
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😶🌫️🤩 It's out!
So happy to share a big piece of my PhD work with the world. 🧩
Using human neural #organoids, we investigated corpus callosum agenesis, a disconnection between the two #brain hemispheres. 🧠
What we found was surprising and exciting... Curious? 📃 👇
📣 Preprint alert!
Check out our latest story, led by @catarinacsmc.
The corpus callosum safeguards interhemispheric communication in the human brain.
𝘈𝘙𝘐𝘋1𝘉 mutations cause agenesis/absence of the CC.
We wanted to know why. 🤓
🧵1/9
tinyurl.com/2s4jtr5z
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Issue 17 highlights:
Feeding activates gut #lipophagy
Biased #multipotency of Schwann cell precursors
ARF #GTPase interactors in lipid signaling
Bimodal Piezo #mechanosensor signaling
Cover by @PhilDexheimer features @Knoblich_lab #Gruffi resource
embopress.org/toc/14602075/2…
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How does in-vitro stress influence #brain #organoids? What cell types are affected, and how can we deal with stressed cells? Our new work now published in @embojournal provides answers! embopress.org/doi/full/10.15… 1/3
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My great honour to name novel master regulator of immune cell metabolism and invasion after "Atossa" a Persian queen, whom connected to my background.
For the full story, watch this video abstract. Stay to the end for the animation of the Persian queen Atossa for whom the master regulator was named. bit.ly/3Jzc9q9
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1/6 Stress in #brain #organoids is widely debated: Are all organoids & all cells affected? Does it exist in vivo? Does it impair cell differentiation? Gruffi, our new algorithm identifies and removes stressed cells from #scRNAseq #singlecell datasets. bit.ly/Gruffi
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How are rare brain tumors and cortical malformations connected & how can organoids help us to find the link? We set out to investigate tuberous sclerosis complex (TSC) and came across an unexpected cell type – see how we did it in this thread! (1/10) science.org/doi/10.1126/scie…
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Introducing the speakers for tomorrows VGZT session on July 9th at 17:30 BST
Details about the talks can be found on the VGZT slack
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2/4 Ábel Vértesy, Postdoc in the @Knoblich_lab, will use cerebral #organoids to study how neurons connect to each other in health and disease, specifically in wild type and monogenic #autism syndrome organoids.
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If you think articles should be valued for their content rather than the journals they were published in, use the citation form "Author(s), year, DOI" on slides and omit the journal name.
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This single (!!!) LGN interneuron has 862 input and 626 output synapses and spans about half the visual field! O_O biorxiv.org/content/10.1101/…
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Also so very very excited that this Perspective from @loicaroyer is finally out in @naturemethods on how deep learning can impact fluorescence microscopy!! nature.com/articles/s41592-0… Thanks so much to Loic and his team!
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Machine learning and statistical methods for clustering single-cell RNA-sequencing data academic.oup.com/bib/advance… github.com/kuanglab/single-c…
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Our new animation is out now! Together with @oncodeinstitute an animation was made that explains the how and why of single cell sequencing. In other words: Every cell is special. Check it out: youtu.be/rdjXA4rTOZ4 via @YouTube #singlecell
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How am I only learning now that `grep -o` extracts only the matching pattern. Also, helps to combine with -P (PCRE) explainshell.com/explain?cmd…
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New paper from Van Oudenaarden + Robin labs (Hubrecht Inst.) showing how tissue dissociation protocols affect cells: buff.ly/2xLiDQp
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Subscription journals are doomed: Two thirds of the world's academic papers are now on Sci-Hub ibt.uk/A6qgt?utm_source=soci…
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#Rstats pkg to simulate colorblindness in figures github.com/clauswilke/colorb… from @ClausWilke & @clairemcwhite
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