@wade_lab

Bacterial genetics/genomics/gene regulation/CRISPR. Tweets by Joe.

 Albany, NY
wadsworth.org/senior-staff/joseph-wade
Joined September 2017
  • Tweets667
  • Following172
  • Followers612
3Media
Joseph Wade retweeted
Galagan Lab@GalaganLab8 May 2025
🚨 Our BoltzNet paper is out @NatureComms! nature.com/articles/s41467-0… We are excited to provide a website with access to all models, code and data boltznet.bu.edu

Predictive biophysical neural network modeling of a compendium of in vivo transcription factor DNA...

Nature Communications - The authors describe BoltzNet, a neural network that learns the energy of transcription factor (TF)-DNA binding from genomic data and can be used to design new binding...

nature.com
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In 1985, the former School of Public Health was created by Health Commissioner David Axelrod in partnership with UAlbany to train students directly within the state health department and its world-renowned Wadsworth Center laboratories. Learn more: buff.ly/402mwxG
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CRISPR-Cas supervises diverse anti-phage defense systems biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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A phage-encoded counter-defense inhibits an NAD-degrading anti-phage defense system biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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Joseph Wade retweeted
Jörg Vogel@JoergLab21 Dec 2024
Apply now, spread the word: three (3) fully funded Helmholtz research groups (assistant prof level) with attractive packages. Topics: RNA-based medicine, microbial RNA, and RNA-based infection research incl. RNA technologies. Great environment for young people. Come and join us.
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New in JB: Oshiro, Seed et al. uncover a novel mechanism to overcome the BREX phage defense system by targeting the BrxC ATPase. journals.asm.org/doi/10.1128… @ASMicrobiology @JBacteriology
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A bacterial NLR-related protein recognizes multiple unrelated phage triggers to sense infection biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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A Salmonella enterica serovar Typhimurium Genome-wide CRISPRi Screen Reveals a Role for Type 1 Fimbriae in Evasion of ... biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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Congratulations Sam! Today, Samantha Lindberg defended her thesis; “Antibody-mediated multicellular behaviors of Salmonella Typhimurium”
Samantha Lindberg with her mentor Nicholas Mantis PhD.

ALT Samantha Lindberg with her mentor Nicholas Mantis PhD.

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Evolution of PqsE as a Pseudomonas aeruginosa-specific regulator of LuxR-type receptors: insights from Pseudomonas and Burkholderia biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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PqsE acts as an adaptor protein for the quorum-sensing transcription factor RhlR in Pseudomonas aeruginosa biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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Giving these another airing... projects on bacterial pathogens, antimicrobial resistance, and basic mechanisms... all with a hint of gene regulation #PhD #opportunities
David Grainger@GraingerLab15 Nov 2024
PhD projects available in our lab all listed in the below link. All focus on bacterial gene regulation, in the context of basic understanding, disease, or anitbiotic resistance. Deadlines in January... findaphd.com/phds/?Keywords=…

grainger birmingham PhD Projects, Programmes & Scholarships - 3 PhDs Listed

findaphd.com
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🚨It’s been a long time coming, but… using my first B. burgdorferi strain as a grad student — 11 years ago — now @NatureComms with @NICHD_NIH Adams Lab post-bacs, we corrected a gene annotation mistake and discovered a conserved flagellar assembly factor! nature.com/articles/s41467-0…

Broadly conserved FlgV controls flagellar assembly and Borrelia burgdorferi dissemination in mice

Nature Communications - The control of flagellar synthesis and function in the Lyme spirochete Borrelia burgdorferi is poorly understood, as this pathogen lacks the typical flagellar sigma factor...

nature.com
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We are excited to share our latest work on the cooperation between RNA polymerase and the ribosome in bacteria: science.org/doi/10.1126/scie… The work was supported by @IGBMC, @Inserm, @CNRS, @unistra, @ERC_research, @IMC_Bio, and @instructhub. 1/7

Molecular basis of mRNA delivery to the bacterial ribosome

Protein synthesis begins with the formation of a ribosome-messenger RNA (mRNA) complex. In bacteria, the small ribosomal subunit (30S) is recruited to many mRNAs through base pairing with the...

science.org
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A Novel Actinobacteria-Specific Ribosome Hibernation Factor in Mycobacterium tuberculosis biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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Exciting times! Our latest preprint is now live 🤩! I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n biorxiv.org/content/10.1101/…

Diverse phage defence systems define West African South American pandemic Vibrio cholerae

Our understanding of the factors underlying the evolutionary success of different lineages of pandemic Vibrio cholerae remains incomplete. Interestingly, two unique genetic signatures define the West...

biorxiv.org
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PhD projects available in @GraingerLab All focus on bacterial gene regulation, in the context of basic understanding, disease, or anitbiotic resistance. Deadlines in January...findaphd.com/phds/?Keywords=…

grainger birmingham PhD Projects, Programmes & Scholarships - 3 PhDs Listed

findaphd.com
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A new research briefing has just been published in @NatureBiotech, summarizing the latest paper from #HIRI's @BeiselLab in collaboration with @YleniaJabalera and Raúl Pérez Jiménez from @CICbioGUNE. Check it out! ⤵️
Nature Biotechnology
@NatureBiotech6 Nov 2024
Replying to @NatureBiotech @CICbioGUNE @basque_for @Helmholtz_HIRI @BRforEM @YleniaJabalera @BeiselLab @IgorTascon
Research Briefing: Ancient and versatile CRISPR–Cas nuclease created with ancestral sequence reconstruction go.nature.com/3ChzwG3
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Tap tap…is the🎙️ still on? This work has been in the works for a long time! We studied the growth behaviors and cell cycle timing of individual TB bacilli and ended up with a series of surprises and a lot of new questions. 1/5 nature.com/articles/s41564-0…

Single-cell imaging of the Mycobacterium tuberculosis cell cycle reveals linear and heterogenous...

Nature Microbiology - Time-lapse imaging of Mycobacterium tuberculosis cells loaded in microfluidic chambers reveals heterogeneity in growth characteristics, atypical modes of polar growth...

nature.com
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Replying to @CedricFeschotte @PopoMicro
Our preprint for this work is now on bioRxiv. This work also reveals a new type of guide RNA directed transposon, a type I-E CAST biorxiv.org/content/10.1101/…

Telomeric transposons are pervasive in linear bacterial genomes

Eukaryotes have linear DNA and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. While many bacteria also have linear chromosomes and plasmids, no...

biorxiv.org
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