Thank you, Georg. I actually retied from the VA and am Professor and MEdical Driector for
Preventive MEdicine at the University of Tennnessee Health Science Center.
#HYPHIP
SPRINT MIND should be reported early next year. Had to finish 4-year visits. #askasn
2.8 drugs, but good drugs, often at high doses. Clearly we all see some more severe patients than were in SPRINT. #askasn
JNC 8 couldn't wait any longer and had not idea SPRINT would end early. #askasn
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I agree with George - at least get <130, but <120 was goal in SPRINT. #askasn
Much more to come soon on renal and CVD outcomes in SPRINT/CKD subgroup. If missed >75 year olds published in JAMA in MAy. #askasn
More visits in intensive group, but not a lot more. Started with 2 drugs or more and got to goal quickly in SPRINT. #askasn
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In SPRINT (& most HTN trials) participants seen/titrated at monthly intervals. Lab 1 month after adding diuretic or RASI #askasn
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Chlorthalidone seemed to lower BP fine in stage 3 CKD and in ALLHAT reduced events similarly. #askasn
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Spironolactone used about 8% of time in intensive group - I would have used even more often. #askasn
Chlorthalidone and amlodipine were primary frugs used in diuretic and CCB classes. #askasn
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All major BP drug classes distributed similarly across both groups, but more often used in intensive group. #askasn
Target BP was <120 in intensive group. Achieved in >50% and most were <130 mm Hg. #askasn
I don't think we assessed exercise in SPRINT, but randomization would balance amount of exercise. #askasn
ACCORDI long-term follow-up) did show CVD reduced with intensive BP in Standard Glycemia group. #askasn