Mitochondriac, Researcher @kronenberglab | @imed_tweets mitochondrial genomes, mtDNA, haplogrep, haplocheck, mtdna-server, mutserve team member @askimed_com
Innsbruck
Joined July 2011
- Tweets1.7K
- Following481
- Followers545
- Likes4.4K
Pinned Tweet
Happy to share with you our latest mtDNA-Server 2: advancing mitochondrial DNA analysis through highly parallelized data processing and interactive analytics academic.oup.com/nar/article…
Happy to share our latest review: **Mitochondrial DNA in Cardiovascular Disease**
We take a look at major CVD phenotypes and their associations with mtDNA-related features, highlighting clinical perspectives and some important pitfalls to watch out for.
sciencedirect.com/science/ar…
A stress-adapted fiber state promotes clonal expansion of deleted mitochondrial DNA
cell.com/cell-reports/fullte…
MitImpact 4: a genome-wide resource for the interpretation of coding and non-coding mitochondrial DNA variants
academic.oup.com/nar/advance…
Securing funding was already like a lottery. AI just means more lottery tickets 😉
This rise is attributable, in part, to the ease of writing applications with artificial-intelligence tools
go.nature.com/4idpSXy
We are excited to host @MBordino (Assistant Professor at UNICATT) tomorrow at our Mitochondrial Lecture Series!
🔬 Topic: Purine enzymes & mitochondrial homeostasis (ADSL Deficiency)
📅 Wed, Oct 21 @ 9:00
📍 Faculty Club (Schöpfstrasse 41) + Webex
Come join the discussion !
Hansi WEISSENSTEINER retweeted
Today on TSEE, we share a personal story that means a lot to me. During my early years as a scientist, I had a chance to work with Doug Wallace, a pioneer considered by many as the father of mitochondrial genetics.
Doug and his team have made discoveries that have transformed our understanding of human evolution and mitochondrial diseases. But his scientific journey wasn't all smooth sailing. Some of the ideas he pursued were met with skepticism and resistance. Ever since my time in his lab, I had several questions I'd never had the chance to ask him.
Last month, @niroshajmurugan and I took the train from NYC to Philadelphia to visit Doug. We talked about his groundbreaking discoveries, the challenges of pursuing unconventional ideas, his vision for the future of energy biology, and his unwavering passion for exploring new ideas.
Nirosha and I are delighted to share a little piece of a precious person with you today. We hope you find the wisdom here valuable.
tseenergy.substack.com/p/exp…
Hansi WEISSENSTEINER retweeted
Today, the MitoCarta Tree of Life Consortium (MitoTOL) is releasing high-accuracy mitochondrial proteomes across diverse eukaryotes to empower studies of physiology, evolution, and disease:
cell.com/consortium/mitocart…
All data can be accessed at:
mitocarta.org
Hansi WEISSENSTEINER retweeted
Today on TSEE, we're sharing a list of 10 cool things about mitochondria. Truly amazing organelles!
From their many functions and behaviors to their potential as targets for enhancing health and treating diseases, we keep discovering new features of mitochondria that reveal how much more they are than powerhouses.
What is this list missing? What are your favorite mitochondrial facts and features?
tseenergy.substack.com/p/10-…
Single-nucleoid imaging in whole cells defines the dynamics of the mtDNA life cycle
biorxiv.org/content/10.64898…
Hansi WEISSENSTEINER retweeted
Delighted to share the final version of our story on mtDNA mutations and aging, published today.
We show mtDNA mutation burden is a sensitive marker of somatic mosaicism (due to CHIP) in blood.
Curious if this pattern will extens to solid organs, too.
rdcu.be/fk4Ou
As we all age, we accumulate mtDNA mutations, but what underlies this hockey stick pattern? See our new pre-print: we treat mtDNA SNV burden as a "trait" and use GWAS to uncover the mechanism in blood. Led by newly minted MD-PhD @rahulg603 w/ @LabNeale.
shorturl.at/IqYY8
Evaluating open LLMs for agentic analysis orchestration in a typical biomedical lab | preprint biorxiv.org/content/10.64898…
Hansi WEISSENSTEINER retweeted
Discovery: When a parasite invades a cell, the cell’s mitochondria react by shedding their outer layers to form brand-new cellular compartments — or organelles — that digest molecular trash.
go.nature.com/4twGhcR
Hansi WEISSENSTEINER retweeted
gbdraw v0.9.1 is out now on Bioconda!
Easily visualize microbial genomes and enjoy the #gbdraw web app completely offline.
📦 Install via Bioconda: bioconda.github.io/recipes/g…
🌐 Try the online app: gbdraw.app/
#bioinformatics #genomics #microbiology #visualization
Hansi WEISSENSTEINER retweeted
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
Cancer mtDNA mutations: metabolic plasticity and therapeutic promise? cell.com/trends/molecular-me…
Cell biology: Killing the prisoner escaping from mitochondria sciencedirect.com/science/ar…
Emerging mechanisms of genome degradation during the mtDNA life cycle
nature.com/articles/s41556-0…
Hansi WEISSENSTEINER retweeted
The first physical evidence that mitochondria exchange information with one another transformed how I think about these beautiful organelles. From isolated beans to social collective.
In 2015, we discovered that the inner membranes of mitochondria, where the oxygen we breathe and food-derived electrons converge, somehow interact BETWEEN mitochondria.
This is the story, with videos and pictures, of how this happened while working with Meagan McManus @MitoLoveLab in Doug Wallace's lab.
open.substack.com/pub/martin…
URMD-Seq: A high-throughput method for scalable detection of ultra-rare mutations in the human mitochondrial genome sciencedirect.com/science/ar…
Hansi WEISSENSTEINER retweeted
.@AHAScience Statement: Mitochondrial Genetics in Cardiovascular Health and Disease ahajournals.org/doi/full/10.… @CircAHA
