Increasing Cholangitis-related Mortality and Persistent Disparities Among U.S. Adults, 1999–2023

Selective Balloon-occluded Transarterial Chemoembolization for Hepatocellular Carcinoma: Mechanis...

Balloon-occluded transarterial chemoembolization (B-TACE) has emerged as a significant advancement in the locoregional treatment of hepatocellular carcinoma. This technique utilizes a balloon...

Enhancing Cross-dataset Zero-shot Generalization in Colorectal Polyp Detection Using Vision-langu...

Colorectal polyp detection from endoscopic images is critical for the early diagnosis of colorectal cancer. However, traditional deep learning methods often suffer from limited generalization when...

Evaluation of Human Serum Albumin in Neurocritical Care: A Narrative Review of Current Applications...

Human serum albumin (HSA) is a multifunctional carrier protein that helps maintain vascular barrier integrity and intravascular fluid homeostasis and has long been used in the management of critica...

Solvent Matters: A Call for Rigorous Consideration of Organic Co-solvents in Drug-target Interact...

Arterial Spin Labeling in Neurosurgical Practice: Emerging Applications and Translational Challenges

ESR1 Testing in the Era of Precision Oncology: A Mini Review

Estrogen receptor alpha, encoded by the ESR1 gene, is a major oncogenic driver in hormone receptor-positive/HER2-negative breast cancers. While endocrine therapies are effective in treating this...

The CYB5R3–mARC1 Redox Axis in Metabolic Dysfunction-associated Steatotic Liver Disease: Mechanis...

Metabolic dysfunction-associated steatotic liver disease affects roughly 38% of adults, yet approved agents do not correct the upstream redox-metabolic perturbations—a depressed nicotinamide adenine...

Redox Remodeling as a Natural Product Strategy in Cancer Therapy: Lessons from Arnicolide C

Perspectives on Cancer Immunotherapy Discussed at a 2025 Symposium in Cuba

Increased Susceptibility to Hepatic Ischemia–reperfusion Injury in MASLD: A Mini Review

Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent worldwide and is frequently encountered in patients undergoing liver transplantation and hepatic surgery....

Transradial versus Transfemoral Access for Intracranial Aneurysm Embolization: A Narrative Review...

Endovascular embolization is a cornerstone treatment for intracranial aneurysms, and transfemoral access (TFA) has traditionally been the default vascular route. Transradial access (TRA) is increas...

Undifferentiated Pleomorphic Sarcoma with a Likely Nonfunctional EWSR1::NF2 Fusion and Complex...

EWSR1 fusions are recurrent genetic alterations in a wide spectrum of mesenchymal tumors and are often associated with specific clinicopathologic entities. However, the presence of an EWSR1 rearran...

Mass Cytometry Reveals Cell Type-specific Immune Remodeling in Placentas of Women with Chronic...

Hepatitis B virus (HBV) vertical transmission remains a major health challenge, and the characteristics of the placental immune microenvironment in chronic infection remain unclear. This study aimed...

Artificial Intelligence-assisted Endoscopic Diagnosis of Upper Gastrointestinal Precancerous...

Upper gastrointestinal precancerous lesions are important targets for cancer screening and prevention. This study evaluated the diagnostic accuracy of artificial intelligence (AI)-assisted endoscopy...

Metabolically Enhanced pH-Dependent Conformational Switching of Polymers for Selective Chemotherapy...

The selectivity of chemotherapy remains limited by systemic toxicity. pH-sensitive polymeric nanocarriers exploit the acidic extracellular environment of solid tumors as a drug-release trigger, but...

LDL Desialylation as a Trigger of Atherogenesis: Sialidase Inhibition as a Novel Anti-atheroscler...

Integrated Single-cell and Bulk Transcriptome Analysis Characterizes a Candidate Ccl4/Lgals3/Egr1...

Traumatic brain injury (TBI) induces neuroimmune activation and metabolic reprogramming in microglia, but the transcriptional regulators underlying these responses remain unclear. This study aimed to...

Biliary Duct Invasion in Colorectal Liver Metastases: Prevalence and Clinicopathologic Correlation...

Biliary duct invasion (BDI) is an underrecognized growth pattern of colorectal cancer (CRC) liver metastases that can mimic intrahepatic cholangiocarcinoma or intraductal papillary neoplasm of the...

Reporting Completeness of Biliary Atresia Organoid Studies: A Scoping Review and Structured Audit

Biliary atresia (BA) is the leading cause of pediatric obstructive cholestasis and a major indication for liver transplantation in infants. Organoid models are increasingly used to investigate BA...