@ychengsy

An explorer of regulatory elements in the genomes. @StJudeResearch @StJude #genomics #functionalgenomics #bioinformatics #genetics #GeneEditing #hematology

 Tennessee, USA
stjude.org/directory/c/yong-cheng.html
Joined April 2011
  • Tweets17
  • Following84
  • Followers82
Mobile elements and functional genomic signatures can be used as landmarks to help us navigate to Genomic Safe Harbors. Congrats to two talent graduate students @dewshrs and co-authors. Wonderful collaborations with Jin @JinXingGenome.
Jin Xing@JinXingGenome22 Sep 2022
Our study on identifying tissue-specific Genomic Safe Harbors (GSHs) for gene therapy is out! tiny.cc/1ofzuz For gene therapy, the integrated transgene cassette needs to: 1. not affect endogenous gene function (safety), 2. have stable expression (efficiency). 1/4
3
To show our appreciation of postdoctoral researchers, St. Jude Research hospital @StJudeResearch has raised the minimal postdoc salary to $70K. This is only part of the amazing environment here. Our group are hiring too! talent.stjude.org/careers/jo… stjude.org/education-trainin…
1
Easy-Prime, the program we developed to improve the design of #PrimeEditing, is now published in @GenomeBiology. Congratulations to @liyc_OU who leads this project and great collaboration with @shengdarqtsai. Github github.com/YichaoOU/easy_pri… Webpage easy-prime.cc/

GitHub - YichaoOU/easy_prime: prime editor gRNA design tool based on ensemble learning

prime editor gRNA design tool based on ensemble learning - YichaoOU/easy_prime

github.com
Genome Biology@GenomeBiology20 Aug 2021
Li, @ychengsy & co present Easy-Prime, a machine learning tool for designing prime editors. It evaluates position and sequence features, such as GC content, mutation type and mutation location (PAM/protospacer), & also how folding of RNA affects editing genomebiology.biomedcentral.…
Sequence features assessed by Easy-Prime

ALT Sequence features assessed by Easy-Prime

2
7
This is an interesting concept. Why not use the well-established oxygen transportation infrastructure to deliver something else.
Nature Communications@NatureComms12 May 2021
Engineered red blood cells as artificial antigen presenting cells for cancer immunotherapy. nature.com/articles/s41467-0… #CancerResearch @rubius_tx
2
Online @nature Polylox barcoding reveals haematopoietic stem cell fates realized in vivo go.nature.com/2vEaY5m
11
2
10
St Jude has been named the No. 1 children's hospital in the U.S. for pediatric cancer treatment! @usnews #pedonc ow.ly/fV9H30cWZQx
4
186
25
374
Can be a useful approach to tackle difficult genomic loci. i.e. HBG1, HBG2 biorxiv.org/content/early/20…
Load more