Jen Eliuk retweeted
๐บ๐ธ The Boatlift That Was Bigger Than Dunkirk
At 10:45 a.m. on September 11, 2001, a Coast Guard lieutenant named Mike Day keyed a radio in New York Harbor and said the only sentence that mattered.
โAll available boats. This is the United States Coast Guard. Anyone wanting to help with the evacuation of Lower Manhattan, report to Governors Island.โ
The boats were already coming.
The bridges were closed. The tunnels were closed. The subways were dead. South of the towers, hundreds of thousands of people had nowhere left to walk. Some jumped into the Hudson. Some stood on seawalls that were never meant to be docks and waited for anything that floated.
Dunkirk took nine days to pull 338,226 Allied soldiers off a beach in 1940.
On 9/11, roughly 800 mariners on about 150 vessels moved as many as 500,000 civilians off Manhattan in about nine hours. Ferries. Tugs. Dinner boats. Pilot boats. Yachts. A retired fireboat. Rubber dinghies that held two people. The largest water evacuation in history.
NY Waterway did not wait for the official call. After the second plane hit, the whole fleet moved. Captain Rick Thornton nosed his ferry against a seawall that was not a slip and started taking people off. Some of them he pulled out of the river. His company alone carried about 158,000 people to Jersey City, Hoboken, Weehawken, Brooklyn, and Queens.
On a normal Tuesday they carried 34,000.
The Staten Island Ferry moved more than 50,000 people and came back the other way with water, bandages, and men who still had work to do in the dust.
The old fireboat John J. Harvey, already retired, tied up near the Museum of Jewish Heritage, took civilians off the seawall, then pumped water when the hydrants downtown died.
Lt. Day later admitted what the day required. โI broke more rules that day than probably Iโve enforced in my whole Coast Guard career.โ
In raw numbers it was bigger than Dunkirk. No boat went down. By nightfall the southern tip of Manhattan had been emptied by people who were not on anyoneโs list of heroes when the morning started.
They were tug captains. Ferry deckhands. Pilots. A lieutenant with a microphone. Ordinary boats answering one sentence.
All available boats.
Huge missed opportunity to use the โI lived bitchโ meme
MCCONNELL releases a photo - and statement.
โTo my fellow Kentuckians โย
ย
โWhen you elected me to a seventh term and made me our Commonwealthโs longest serving Senator, you did so trusting that Iโd keep showing up to fight for you every day. And over the past several weeks, Elaine and I have appreciated both your well wishes and your honest questions about what was keeping me away from the Senate.
ย
โYou all know how folks of my generation often hesitate to share the vulnerability that comes with growing older. Even in the public eye, I feel that same instinct โ I canโt help it.
ย
โBut at the same time, Iโve had more than my share of experience with physical vulnerabilities. Surviving childhood polio meant spending my entire life with mobility challenges. They havenโt exactly gotten easier to manage with age. And last month, I took a fall which landed me in the hospital.
ย
โMy doctors have confirmed that I didnโt break any bones or suffer a concussion. I didnโt have a heart attack or a stroke. I donโt have any tumors or hemorrhages. But I was briefly unconscious and was taken to the hospital. While receiving excellent care over the past several weeks, Iโve also had to deal with a mild case of pneumonia.
ย
โI can assure you that Iโve been a good patient. At my age, I tend to do what my doctors tell me to do. Iโve submitted to every test they can think of to help figure out what caused this incident. And Iโm continuing to do everything they ask to speed my recovery. In fact, with signs of continued progress, Iโve been able to move from hospital care to a rehabilitation center where Iโll keep regaining my strength.
ย
โAs much as it frustrates me, this process takes time. And on the advice of my doctors, I wonโt be able to return to the Senate floor to vote quite yet. But rest assured that, in the meantime, Iโm not taking a break from the Senate business that matters to you. Iโve been working closely with my legislative staff on current issues, and with my Kentucky team who help me provide timely constituent services across our Commonwealth. Iโve also been keeping in touch with my Senate colleagues on the appropriations process, midterm politics, and everything in between.
ย
โYouโre right to expect your representatives to work hard for you. And part of my decision to retire at the end of my termย this comingย January was being honest about theย demands of Senate work.ย But I still have unfinished business to complete on your behalf, and I have every intention of finishing the job you elected me to do.
ย
โIโll keep working hard to get back on the Senate floor as soon as possible. And Iโll keep you posted on the progress of my recovery. Until then, Iโm so grateful for your prayers and well wishes.โ
Jen Eliuk retweeted
Jour 127, orbite 1968 โ Cette aurore รฉtait absolument spectaculaireโฆ Elle ondulait et dansait sous nos pieds, ร perte de vue, et sa lumiรจre รฉtait si intense quโelle illuminait toute la Station de reflets verts ๐.
Nous avons eu la joie dโen observer plusieurs depuis le dรฉbut de la mission, mais celleโci โ bien trop lumineuse pour mes rรฉglages habituels de photos dโaurores โ nous a tous รฉmerveillรฉs !
Des moments comme celuiโci ne perdent jamais de leur magie, mรชme ici, et tout lโรฉquipage se retrouve ร chercher la meilleure place prรจs dโun hublot ๐
๐ธ @esa / @NASA โ S. Adenot
#ฮตpsilon โข @esaspaceflight โข @esaspaceweather โข @ESA_fr โขย @Space_Station โข @NASAJohnson โข @CNES
Jen Eliuk retweeted
Auschwitz was at the end of a long process. We must remember that it did not start from gas chambers.
This hatred was gradually developed by humans. From ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder.
Auschwitz took time.
ALT A bird's-eye view of a former Auschwitz II-Birkenau camp showing a wide dirt pathway flanked by parallel rows of barbed-wire fences. Groups of visitors walk along the path, surrounded by the remnants of brick structures and barracks, now reduced to foundations. Green grass contrasts with the somber history of the site, as the path leads toward a guard tower in the distance.
Jen Eliuk retweeted
๐จJAYS WS JERSEY GIVEAWAY๐จ
Weโve decided to giveaway an official Nike Toronto Blue Jays jersey of your choice with any player on the back! โพ๏ธ
To enter:
1. FOLLOW @BodogCA
2. LIKE โค๏ธ & RT ๐ this tweet.
3. Reply with your size & player!
Good luck! ๐จ๐ฆ๐จ๐ฆ๐จ๐ฆ๐จ๐ฆ
Jen Eliuk retweeted
Your lungs make blood too. UCSF scientists just discovered lung stem cells that produce blood, just like bone marrow. This could change how we treat blood and immune disorders. tiny.ucsf.edu/Pwa7qn
Jen Eliuk retweeted
Today, we laid wreaths at the National War Memorial in Ottawa to honour the Canadians who served and sacrificed in Afghanistan.
Canadaโs military mission in Afghanistan ended #OnThisDay in 2014.
๐: ow.ly/Hrhb50Vgzh8
#CanadaRemembers
I just wrote a review on Non-Toxic All Purpose Cleaner yotpo.com/go/z5O7hXKf by Defunkify
Jen Eliuk retweeted
You're hearing a lot about Tim Walz and free school lunches. You're not hearing enough about the behind-the-scenes role of Philando Castile's mom in getting that bill passed. sahanjournal.com/education/fโฆ
Jen Eliuk retweeted
๐ข ๐๐ก๐ฒ ๐๐๐๐๐ข๐ง๐๐ฌ ๐๐๐ง ๐๐๐ฏ๐๐ฅ๐จ๐ฉ ๐๐๐ญ๐ก๐จ๐ฅ๐จ๐ ๐ข๐๐ฌ ๐๐ข๐ฆ๐ข๐ฅ๐๐ซ ๐ญ๐จ ๐๐๐ซ๐ฌ๐ข๐ฌ๐ญ๐๐ง๐ญ ๐๐๐๐๐ ๐๐ง๐ ๐๐จ๐ฌ๐ญ-๐๐ง๐๐๐๐ญ๐ข๐จ๐ฎ๐ฌ ๐๐/๐๐
๐? ๐ข
๐ฌ ๐๐จ๐ฆ๐ฆ๐จ๐ง ๐๐๐๐ก๐๐ง๐ข๐ฌ๐ฆ: ๐๐ง๐๐จ๐ง๐ญ๐ซ๐จ๐ฅ๐ฅ๐๐ ๐๐ฆ๐ฆ๐ฎ๐ง๐ ๐๐๐ญ๐ข๐ฏ๐๐ญ๐ข๐จ๐ง.
Both persistent COVID and post-infectious ME/CFS and post-vaccine syndrome share a common basis: an overactive immune response. In our study, we propose the presence of:
1๏ธโฃ ๐๐๐ซ๐ฌ๐ข๐ฌ๐ญ๐๐ง๐๐ ๐จ๐ ๐๐ข๐ซ๐๐ฅ ๐๐ง๐ญ๐ข๐ ๐๐ง๐ฌ ๐จ๐ซ ๐๐๐ฃ๐ฎ๐ฏ๐๐ง๐ญ๐ฌ:
โช๏ธ ๐๐ก๐ซ๐จ๐ง๐ข๐ ๐ฏ๐ข๐ซ๐๐ฅ ๐ข๐ง๐๐๐๐ญ๐ข๐จ๐ง: after a viral infection, such as SARS-CoV-2 or Epstein-Barr virus (EBV), viral antigens may remain in the body, triggering a continuous immune response.
โช๏ธ ๐๐๐๐๐ข๐ง๐๐ญ๐ข๐จ๐ง: Vaccines contain adjuvants designed to stimulate the immune system. In genetically predisposed individuals (HLA-DRB1), this stimulation may be excessive, leading to uncontrolled immune activation similar to a viral infection. In addition, the introduced viral antigens could have molecular mimicry with ACTH, exacerbating the immune response and potentially contributing to the development of autoimmunity against ACTH.
2๏ธโฃ ๐๐ฎ๐ญ๐จ๐ข๐ฆ๐ฆ๐ฎ๐ง๐ข๐ญ๐ฒ ๐๐ ๐๐ข๐ง๐ฌ๐ญ ๐ญ๐ก๐ ๐๐๐๐ง๐จ๐ก๐ฒ๐ฉ๐จ๐ฉ๐ก๐ฒ๐ฌ๐ข๐ฌ:
* Both conditions can lead to autoimmune inflammation of the adenohypophysis (autoimmune hypophysitis), resulting in hormonal dysfunction, especially ACTH production.
3๏ธโฃ ๐๐ฒ๐ฉ๐๐ซ๐๐จ๐ซ๐ญ๐ข๐ฌ๐จ๐ฅ๐๐ฆ๐ข๐ ๐๐ง๐ ๐๐๐ ๐๐ฑ๐ข๐ฌ ๐๐ฒ๐ฉ๐จ๐๐ฎ๐ง๐๐ญ๐ข๐จ๐ง:
* Chronic inflammation and proinflammatory cytokine production can alter the hypothalamic-pituitary-adrenal (HPA) axis, leading to low cortisol levels, which exacerbate fatigue and other symptoms.
๐ ๐๐ฒ๐๐ฅ๐ ๐จ๐ ๐๐ฒ๐ฉ๐๐ซ๐๐๐ญ๐ข๐ฏ๐๐ญ๐ข๐จ๐ง ๐๐ง๐ ๐๐ฆ๐ฆ๐ฎ๐ง๐ ๐๐๐ฉ๐ฅ๐๐ญ๐ข๐จ๐ง:
โช๏ธ ๐๐ง๐ข๐ญ๐ข๐๐ฅ ๐๐ฒ๐ฉ๐๐ซ๐๐๐ญ๐ข๐ฏ๐๐ญ๐ข๐จ๐ง: Initial immune response is excessive, with high cytokine production and CD8 T-cell activation.
โช๏ธ ๐๐ฆ๐ฆ๐ฎ๐ง๐ ๐๐ฑ๐ก๐๐ฎ๐ฌ๐ญ๐ข๐จ๐ง: Over time, this hyperactivation leads to T-cell exhaustion, decreasing the body's ability to control infection and exacerbating the pathology.
โช๏ธ ๐๐ฒ๐ฉ๐จ๐๐จ๐ซ๐ญ๐ข๐ฌ๐จ๐ฅ๐ข๐ฌ๐ฆ: Insufficient cortisol maintains the state of immune hyperactivation, perpetuating inflammation and hindering resolution of the immune cycle.
๐ ๐๐ฏ๐ข๐๐๐ง๐๐ ๐๐ง๐ ๐๐ฅ๐ข๐ง๐ข๐๐๐ฅ ๐๐ข๐ฆ๐ข๐ฅ๐๐ซ๐ข๐ญ๐ข๐๐ฌ:
โช๏ธ ๐๐ก๐๐ซ๐๐ ๐๐ฒ๐ฆ๐ฉ๐ญ๐จ๐ฆ๐ฌ: chronic fatigue, muscle and joint pain, sleep disturbances, cognitive problems, and post-exertional malaise.
โช๏ธ ๐๐จ๐ฆ๐ฆ๐จ๐ง ๐๐๐ง๐๐ญ๐ข๐: Polymorphisms in the HLA-DRB1 gene predispose to an exaggerated immune response to both viral infections and vaccine components.
๐ ๐๐จ๐ง๐๐ฅ๐ฎ๐ฌ๐ข๐จ๐ง: Our review suggests that both Long COVID and post-infectious ME/CFS and post-vaccination syndromes could be considered as part of the autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA). These findings underline the need for a personalized therapeutic approach that takes into account the genetic predisposition and immune status of the patient.
๐๐ ๐๐จ๐ฐ ๐๐๐ง ๐๐จ๐ฆ๐ ๐๐๐๐๐ข๐ง๐๐ฌ ๐๐ซ๐ข๐ ๐ ๐๐ซ ๐๐๐ซ๐ฌ๐ข๐ฌ๐ญ๐๐ง๐ญ ๐๐๐๐ฅ๐ญ๐ก ๐๐ซ๐จ๐๐ฅ๐๐ฆ๐ฌ? ๐๐
1๏ธโฃ ๐๐๐๐ก๐๐ง๐ข๐ฌ๐ฆ ๐จ๐ ๐๐๐ญ๐ข๐จ๐ง:
โช๏ธ Vaccines contain adjuvants and antigens designed to stimulate robust immune responses.
โช๏ธ In some cases, this stimulation can lead to a dysregulated autoimmune response, similar to that seen in diseases such as systemic lupus erythematosus.
2๏ธโฃ ๐๐๐๐๐ข๐ง๐๐ฌ ๐๐ง๐ฏ๐จ๐ฅ๐ฏ๐๐:
โช๏ธ COVID-19: Cases of prolonged symptoms after infection or vaccination, known as Long COVID or post-COVID syndrome, have been reported.
โช๏ธ Hepatitis B and C, HPV: Some individuals develop ME/CFS after vaccination, related to autoimmunity and immune alterations.
3๏ธโฃ ๐๐ข๐ฌ๐ค ๐
๐๐๐ญ๐จ๐ซ๐ฌ:
โช๏ธ Genetic predisposition such as polymorphisms in the HLA-DRB1 gene may increase susceptibility to abnormal immune responses.
โช๏ธ Viral persistence or chronic antigen exposure may trigger a continuous and pathologic immune response.
๐๐ ๐๐ข๐ ๐ฒ๐จ๐ฎ ๐ค๐ง๐จ๐ฐ ๐ญ๐ก๐๐ญ ๐ฏ๐๐๐๐ข๐ง๐๐ฌ ๐๐๐ฌ๐ข๐ ๐ง๐๐ ๐ฐ๐ข๐ญ๐ก ๐๐๐๐ง๐จ๐ฏ๐ข๐ซ๐ฎ๐ฌ๐๐ฌ ๐ฆ๐๐ฒ ๐ก๐๐ฏ๐ ๐ ๐ฌ๐ฅ๐ข๐ ๐ก๐ญ๐ฅ๐ฒ ๐ข๐ง๐๐ซ๐๐๐ฌ๐๐ ๐ซ๐ข๐ฌ๐ค ๐จ๐ ๐ญ๐ซ๐ข๐ ๐ ๐๐ซ๐ข๐ง๐ ๐ฉ๐ซ๐จ๐ฅ๐จ๐ง๐ ๐๐ ๐ข๐ฆ๐ฆ๐ฎ๐ง๐ ๐ซ๐๐ฌ๐ฉ๐จ๐ง๐ฌ๐๐ฌ ๐๐จ๐ฆ๐ฉ๐๐ซ๐๐ ๐ญ๐จ ๐ฆ๐๐ฌ๐ฌ๐๐ง๐ ๐๐ซ ๐๐๐ ๐ฏ๐๐๐๐ข๐ง๐๐ฌ?
Adenoviruses used as vectors may persist longer in the body, exposing the immune system to viral components for extended periods.
๐ฆ Adenoviruses are linear double-stranded DNA viruses and remain in an episomal condition in the nucleus. The mechanism of adenovirus vector persistence has not yet been elucidated. But they can persist for a long time in the organism. It is thought that it could be by their integration into the genome or by episomal gene duplication facilitated by the transcription machinery of the host cells. That is, it could happen that it transmits episomes to its cells as occurs in Epstein-Barr virus without lytic phase. During mitosis, EBV episomes are bound to chromosomes in metaphase through EBNA-1, allowing efficient segregation of episomes into daughter cells.
๐ฌ This theoretical phenomenon could predispose certain genetically susceptible individuals to develop chronic autoimmune or inflammatory disorders, as discussed in the context of ASIA syndrome. In contrast, messenger RNA vaccines, by rapidly degrading after inducing the desired immune response, limit this prolonged exposure.
๐โ ๏ธ Regardless of the type of vaccine against COVID-19 or other pathologies, whether messenger RNA or adenoviral vector, there is a theoretical possible risk of developing autoimmune disease only in individuals with certain genetic alleles, such as HLA-DRB1. The key lies in prolonged exposure to viral antigens, which could trigger persistent autoimmune responses.
๐ฌ mRNA vaccines are characterized by rapidly degrading after inducing the desired immune response, thus limiting prolonged exposure to viral components. In contrast, adenoviral vector-based vaccines can persist in the body longer, potentially increasing the risk of a longer-lasting autoimmune reaction in susceptible individuals.
๐ก It is crucial to remember that these risks are rare when compared to the total number of vaccinated individuals and that all vaccines, including adenovirus and messenger RNA vaccines, are critical to combat pandemic diseases such as COVID-19 at the species level. However, understanding these differences may help improve future vaccine design and surveillance for potential adverse effects in these susceptible individuals.
๐ Recall that vaccines save millions of lives and prevent serious consequences of infections in the majority of the population. However, it is crucial to recognize that they may also present risks in some susceptible individuals.
๐งฌ๐ HLA-DRB1 genetic alleles play a crucial role in predisposition to diseases such as Long COVID, myalgic encephalomyelitis (ME/CFS) and ASIA syndrome, as well as in post-vaccine syndromes.
๐ These HLA-DRB1 alleles are part of the HLA (human leukocyte antigen) system, which regulates how the immune system recognizes and responds to foreign antigens, such as viruses and vaccine components. In individuals with certain HLA-DRB1 alleles, the immune system may trigger excessive or inappropriate responses to these antigens, leading to autoimmune conditions and inflammatory syndromes.
๐ฆ This explains why some patients, after significant viral infection or vaccination, may develop persistent autoimmune reactions. In the case of Long COVID and ME/CFS, persistence of viral antigens could trigger an autoimmune response against self tissues, including the pituitary gland.
๐โจ In a ๐ค๐๐ฒ ๐ฌ๐ญ๐ฎ๐๐ฒ, patients who developed hypophysitis after infection with the first SARS-CoV recovered their health months after treatment with replacement corticosteroids. This finding underscores the importance of detecting hypophysitis early to prevent permanent damage.โก๏ธ ncbi.nlm.nih.gov/pmc/articleโฆ
๐ง Hypophysitis can cause a decrease in ACTH production, crucial for adrenal function and immune response. Controlling ACTH levels is critical if symptoms such as chronic fatigue, orthostatic hypotension and sleep disturbances are present after a viral infection.
๐ Early administration of replacement corticosteroids can stop ACTH secretion and prevent autoimmunity against this hormone, thus protecting the pituitary from further damage. Over time, as hypophysitis and viral infection subside, the dose of replacement corticosteroids can be gradually reduced until normal pituitary function is restored.
๐Challenges in HPA Axis Evaluation in Patients with Long COVID, ME/CFS and Post-Vaccine Syndromes.
Studies are often limited to single morning cortisol measurements, ignoring diurnal variability and cortisol response to physical/mental stress, which may underestimate problems in the HPA axis. In addition, CRH or ACTH stimulation tests, crucial for assessing pituitary and adrenal function, are not frequently performed.
It is crucial to detect HPA axis dysfunctions as early as possible to prevent adrenal atrophy due to low ACTH levels. Newly diagnosed patients may recover HPA axis function if autoimmune or direct damage by infection to the pituitary is detected early. Conversely, as time passes, the risk of pituitary damage from autoimmunity against ACTH increases, leading to further adrenal atrophy and the need for hydrocortisone replacement therapy. Early detection and treatment of these dysfunctions is crucial to improve the clinical management and quality of life of these patients.
#Research #Health #Autoimmunity
Jen Eliuk retweeted
โWhat chafes critics, even those who might consider themselves progressive, is that they expect reconciliation to instead look like a kind of reversal, rewinding the tape of history to some museum-diorama past.โ apple.news/AmvjjRLoFRpm_7V0vโฆ
My Lucy cat is rapt watching @taylorswift13 Reputation Stadium Tour, especially the light shows ๐ Another #swiftie is born
Wow I just watched That Hamilton Woman last night, had no idea it was based on a true story ๐ Real lovers, real battleโฆ Great movie!
I canโt tell you how depressing it is to grow up in B.C., thinking youโve won the lottery of life, to be in the most beautiful and wildlife-abundant place in the worldโฆ Only to discover we are destroying it as fast as humanly possible, for profit! Fuck you, owls! Need that $$$
Canada is in court over the disappearance of spotted owls โ as the countryโs last wild raptor has gone missing. In the age of extinction, hereโs why a โprecedent-settingโ case, which could change Ottawaโs approach, matters. via @sarahcox_bc: thenarwhal.ca/spotted-owl-feโฆ
Jen Eliuk retweeted
This is Togo. He's the lesser-known sled dog who helped save an entire Alaskan town in 1925. He's also our latest 15/10
