@AlexSilverMSTP

https://xitter.cf/t.co/eV5HOgV0d0 | MD/PhD student in Savona Lab at @VanderbiltMSTP | #ClonalHematopoiesis #DoubleDocs #HeForShe #BLM | he/him | Views are my own

 Vanderbilt Medical School
scholar.google.com/citations?user=w038f10AAAAJ&hl=en&oi=ao
Joined January 2012
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I recently set up an account on the microblogging site joinmastodon.org/ and am looking for people to follow, especially in the #science and #medicine communities. Who here is on #Mastodon? If yes, drop your handle in the replies! You can find me @[email protected]
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Looking forward to the many new faculty colleagues we will recruit to @VanderbiltU & @VUMCDiscoveries with support from @NIH_CommonFund's FIRST initiative in the years ahead! Thank you @DrCHWilkins, @ahasty4 & @VU_Provost for your leadership. news.vumc.org/2023/06/21/van…
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The published version of our study on the association between clonal hematopoiesis and Alzheimer's disease (AD) is now available. Thread below! nature.com/articles/s41591-0…

Clonal hematopoiesis is associated with protection from Alzheimer’s disease

Nature Medicine - Clonal hematopoiesis of indeterminate potential (CHIP) was found to be associated with a protective effect from Alzheimer’s disease (AD) in large population-based cohorts.

nature.com
Nature Medicine
@NatureMedicine15 Jun 2023
#ClonalHematopoiesis of indeterminate potential was found to be associated with a protective effect from #Alzheimers disease in population-based cohorts. @jaiswalmdphd @StanfordMed #AD #Hematopoiesis #CHIP nature.com/articles/s41591-0…
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Alex Silver retweeted
The BMJ
@bmj_latest17 May 2023
The proportion of women among Lasker Award recipients has not changed in more than 70 years, finds study bmj.com/content/381/bmj-2023…

Women and non-white people among Lasker Award recipients from 1946 to 2022: cross sectional study

Objective To determine whether gender and racial inequities exist among Lasker Award recipients. Design Observational, cross sectional analysis. Setting Population based study. Participants Recipie...

bmj.com
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Recurring somatic mutations are uncommon and inconsequential right? Nope! Out today in @ScienceAdvances, our work led by @J__Stock disproves these widely held assumptions, discovering a new class of non-coding somatic mutations in blood with phenotypic impact. 🧵👇
Josh Weinstock@josh_weinstock26 Apr 2023
Little is known about non-coding somatic mutations in people without cancer. To learn a bit more about this class of mutations, we comprehensively profiled blood somatic mutations across ~43K individuals from the TOPMed consortium, now out @ScienceAdvances science.org/doi/10.1126/scia…

The genetic determinants of recurrent somatic mutations in 43,693 blood genomes

Somatic mutations are common in blood from healthy individuals and have germline genetic causes and health consequences.

science.org
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Out in @Nature today, we describe a new method "PACER" to estimate clonal expansion rate and use it to identify that aberrant TCL1A activation as a cause of #CHIP expansion and potential therapeutic target @J__Stock @Jk_Gopakumar @jaiswalmdphd nature.com/articles/s41586-0…
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Fatty liver dz is v common but our understanding of who progresses to inflammation & fibrosis is limited. In @Nature, we discover clonal hematopoiesis as a modifiable risk factor for precision liver dz prevention. nature.com/articles/s41586-0… @waihaywong @connoremdin B Ebert [1/19]
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Clonal hematopoiesis is an expansion of blood stem cell clones caused by mutations in a recurrent set of genes. Our paper on factors mediating expansion of these mutant clones is published today. nature.com/articles/s41586-0… Thread below...

Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

Nature - Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies...

nature.com
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@RAMillager presented his recently published work on "Behavioral and cognitive-affective features of stuttering in preschool-age children" and won first prize!! 😍👏👏👏 Check out the publication here: doi.org/10.1016/j.jfludis.20…
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Excited to share the last part of my PhD work, where we track co-receptor signaling dynamics during B cell activation! Great collaboration with @KalocsayMarian biorxiv.org/content/10.1101/…

A Spatiotemporal Map of Co-Receptor Signaling Networks Underlying B Cell Activation

The B cell receptor (BCR) signals together with a multi-component co-receptor complex to initiate B cell activation in response to antigen binding. This process underlies nearly every aspect of...

biorxiv.org
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Please join us in welcoming our new @YalePathology resident announced on #MatchDay23. Matthew Madden, MD, PhD - @madden_mz - is from @VUMedicine. Dr. Madden is one of 10 new #pathology residents joining @YNHH and @YaleMed bit.ly/3lqdcSy
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Join us Tues 3/28 at 10am in 214 LH for Andrew Boal's @EyeBoal Dissertation Defense "Retinal Ganglion Cell Excitability and Adaptations to Ionic Stress in Glaucomatous Optic Neuropathy" completed in Dr. David Calkins lab in the Neuro Grad Program @VanderbiltBrain and @VUMCEye!
Smiling man with glasses, brown hair, blue button up collard shirt, standing in from of a blurred background of green trees.

ALT Smiling man with glasses, brown hair, blue button up collard shirt, standing in from of a blurred background of green trees.

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So proud of M4 @Ayeshamyar for winning the Michael Fowler Educational Excellence Award!!
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Ever wanted to do #tractography but didn't have #diffusion #MRI? Check out our preprint using #AI to propagate streamlines directly on T1w MRI, no diffusion needed! biorxiv.org/content/10.1101/… Big thanks to @grahamwjohnson @dc_moyer @kurtschilling5 @FrancoisRheault & @MASI_Lab team!
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Great Medicine Grand Rounds by @AmyOxentenkoMD on Equity and Allyship! I’ve been fortunate to have amazing mentors and sponsors including @endocelldoc but not everyone is so lucky. #PromoteHer
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Ever wondered where to find patients for a CHIP/cardiovascular disease clinical trial? How about in the cardiac cath lab. 🧵medrxiv.org/content/10.1101/…
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Congratulations to @DrFlashHeart for being selected as a 2023 @the_asci Emerging Generation Awardee! Caitlyn is a leader in #CHIP and kidney genetics. We are lucky to have her as part of our extended research group! the-asci.org/controllers/asc…

Home - The American Society for Clinical Investigation

This is the home page for The American Society for Clinical Investigation website.

the-asci.org
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