Professor of Structural Biology @queensu
Kingston, Ontario
Joined August 2018
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John Allingham retweeted
Flow cytometry fans, Queen‘s University, Kingston, ON 🇨🇦 is looking to hire a Flowcore Manager. Please apply widely and RT
queensu.njoyn.com/cl4/xweb/X… – at Kingston, Ontario
Hooray for Caitlin Doubleday! (The petite one in the centre) She breezed through her MSc defence and will join @structureSara and her amazing group at McMaster! 👏👏
John Allingham retweeted
Another new lab milestone: publication of our first research paper! We identify a strategy to inhibit cell entry of diverse #coronaviruses - congrats to our PhD student Emma @emmavleblanc for her excellent work leading this project! #newPI @DbmsTweets
nature.com/articles/s41598-0…
Kinesin-8s regulate mitotic spindle size and position, and are thus critical to accurate chromosome segregation. We show how kinesin-8s alternate between their pro-motility and pro-microtubule-depolymerization states to control spindle position and size. nature.com/articles/s41467-0…
John Allingham retweeted
A paper published in @naturemethods presents ColabFold: a free and accessible platform for protein folding that provides accelerated prediction of protein structures and complexes using AlphaFold2 or RoseTTAFold. go.nature.com/3wZl5Bu
Bound nucleotide can control the dynamic architecture of monomeric actin | Nature Structural & Molecular Biology nature.com/articles/s41594-0…
Kinesin-8s are motile #microtubule depolymerases. @matthieuBenoit1 and @SosaLab4 in collaboration with @queensu researchers Byron Hunter, Caitlin Doubleday and Daria Trofimova provide a library of high-resolution structures that show how they function. dlvr.it/SKrQYT
Our study to understand how kinesin-8 can have both motility and microtubule depolymerization activities
7 #CryoEM structures @SosaLab4
Data collected @SEMC_NYSBC
Collaboration with @AllinghamJohn lab, biochem & X-ray structure by Byron Hunter
#microtubule
dlvr.it/SKrQYT
Our new manuscript with @SosaLab4 and @matthieuBenoit1 in bioRxiv shows the structural basis of motility and microtubule depolymerization by kinesin-8, and how it alternates between these activities!
Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape biorxiv.org/cgi/content/shor…
John Allingham retweeted
Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape biorxiv.org/cgi/content/shor… #bioRxiv
John Allingham retweeted
Let's start the new year with the CanFunNet Seminar series! Featuring @jessiemacalpine and @jonathan_czb presenting their research on January 20 at 2pm EST. DM for details #CFNSeminarSeries
This is what tenacity looks like 👉🏼 @IrsaShoukat . Congratulations and best wishes for your bright future, Dr. Shoukat 👏👏👏
John Allingham retweeted
Today with @emblebi, we're launching the #AlphaFold Protein Structure Database, which offers the most complete and accurate picture of the human proteome, doubling humanity’s accumulated knowledge of high-accuracy human protein structures - for free: dpmd.ai/alphafolddb 1/
John Allingham retweeted
Brief update on some exciting progress on #AlphaFold! We’ve been heads down working flat out on our full methods paper (currently under review) with accompanying open source code and on providing broad free access to AlphaFold for the scientific community. More very soon!
John Allingham retweeted
nature.com/articles/s41467-0…
Just out! Significant additions to the preprint biorxiv.org/cgi/content/shor… are the separation of coexisting motor-head conformations and improved resolution (2.7-3.9 Å now). @matthieuBenoit1 @HernandoSosa4 @SEMC_NYSBC @cryoEM_Papers #microtubule #kinesin
Great work by a talented and tireless PhD student. Keep a look out for when @IrsaShoukat is on the job market later this year!
A great flash talk by @IrsaShoukat elucidating the roles of force producing motors in Candida albicans #CFNGLM21
Hang on until the final sessions of @CanFunNet #CFNGLM21 today in which @Poo_sridhar @IrsaShoukat and Tanya Sharma from the Loewen and Allingham labs will introduce some key players in fungal chemotropism and genome (in)stability! Happy 🍄 Friday!