Internal Medicine resident @CU_medicine, MD PhD @HarvardMITmdphd, PhD @liaulab. Passionate about oncology, drug resistance and women in science and medicine.
Joined November 2018
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Check these amazing preprints from my PhD lab, @liaulab! Congrats to @applecannon23, Olivia, @clee_bio, @Palgosavi, @proteinnns and @brian_b_liau! Truly a tour de force of chemical biology!
Excited to share 2 preprints, together showing how mechanisms of a molecular glue & E3 ligase cancer mutations serendipitously converge to cause neomorphic protein degradation in distinct contexts. Highlights below: 1/17
#1: biorxiv.org/content/10.1101/…
#2: biorxiv.org/content/10.1101/…
Excited to share that our paper discovering drug addiction to PRC2 inhibitors is out at @nchembio! Congrats to my co-lead author, Hui Si Kwok, and the @liaulab PRC2 team including Allison Siegenfeld, Julia Morriss, @proteinnns, @StephenKissler and @brian_b_liau! We did it!
A new paper from @brian_b_liau, @AllyFreedy @liaulab profiled the resistance landscape to PRC2 inhibitors in EZH2-mutant lymphoma with CRISPR suppressor scanning revealing drug addiction mutations and a repressive methylation ceiling. Free to read link at rdcu.be/c8v1l
We're honored that our work was featured in a News and Views authored by Tyler Reich, @thePeterLewis and @PeterLewisLab. Thank you for the broader perspective on our work! rdcu.be/c8vZp
Check out my Tweet thread below on the preprint for a quick summary of the paper! xitter.cf/AllyFreedy/status/1511…
Epigenetic dysregulation is a cancer hallmark. Restoring the benign epigenetic state is effective therapeutically, but what about pushing tumors further into epigenetic dysregulation? Check out our preprint out @biorxiv from @liaulab to learn more! biorxiv.org/content/10.1101/…
Thank you @SchreiberStuart! I would not have become the scientist I am today without your example, support and mentorship over all of these years. Thank you for opening the door to chemistry and chemical biology to me and so many other women scientists!
Ally Freedy retweeted
I want to share an inspiring teaching experience I had this semester. I had a privilege to teach biochemistry to Emily @PharmFatale who can’t see the structures like you and I can. At first I was skeptical cause I thought that chemistry is highly visual.
Congratulations to @nicklue8, @Emma_M_Garcia_1 and the the DNMT3A team @liaulab! Check out this paper for a tour de force in base editing tiling mutagenesis combined with an activity based reporter all followed up with rigorous cellular and biochemical validation!
Our paper on DNMT3A base editor scanning is out in @nchembio!! Check it out if you like DNA methylation, base editor screens, and protein biochemistry. Super thankful to my amazing PI (@brian_b_liau), labmates (@liaulab), and especially my teammate @Emma_M_Garcia_1.
Congratulations @StephenKissler!! @CUBoulder is so lucky to have you!
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Incredible work from @liaulab led by Allison Siegenfeld and Shelby Roseman developing a new method called LIMe-Hi-C to discover Polycomb-Lamina antagonism! Congratulations all!!
Today we share in @NatureComms our method called LIMe-Hi-C (Lamina-Inducible Methylation and Hi-C) & how we used it to uncover Polycomb-Lamina antagonism. Big thanks to Allison, Shelby, @MartinAryee, and @liaulab, & to reviewer 1 for the detailed comments. nature.com/articles/s41467-0…
Ally Freedy retweeted
Today we're thrilled to bring you a special spotlight of one of our HWIC x Harvard Chem Club pairings!
"We never stop being a mentee and it's never too early to be a mentor" -@jenheemstra
Read more about Olivia and Christie at harvardwic.org/spotlight
Ally Freedy retweeted
Super excited to announce that we’ve just submitted the latest @liaulab ~manuscript~! Tldr: we used base editors + a methylation reporter to do a mutational scan of DNMT3A, a key cancer gene. Highlights below, but check out our preprint at @biorxiv!
biorxiv.org/content/10.1101/…
Epigenetic dysregulation is a cancer hallmark. Restoring the benign epigenetic state is effective therapeutically, but what about pushing tumors further into epigenetic dysregulation? Check out our preprint out @biorxiv from @liaulab to learn more! biorxiv.org/content/10.1101/…
This work was a huge team effort co-led by me and Hui Si Kwok! We could not be more thankful to Allison Siegenfeld, @proteinnns, Julia Morriss, @StephenKissler, @brian_b_liau and the whole PRC2 team!