Academic startup at the interface of chemistry and cancer epigenetics @ Harvard CCB 🔬
Cambridge, MA
Joined June 2018
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🧵 We're looking for a chemical biology postdoc! Details in following tweets but please email our awesome lab admin Lizzy Swenson ([email protected]) a 1-page cover letter, CV, and 1-page summary of scientific research as a single PDF file if interested!
Familiarity and/or training in any aspect of genomics, sequencing data analysis, and/or CRISPR genome editing is a plus but not required. Enthusiasm to learn new areas of biology and data analysis as well as work with and mentor others are essentials.
Postdocs can also expect to be involved in multiple projects. Please send a 1-page cover letter, CV, and 1-page summary of scientific research as a single PDF file to Lizzy Swenson, [email protected].
Liau Lab retweeted
Today we share in @NatureComms our method called LIMe-Hi-C (Lamina-Inducible Methylation and Hi-C) & how we used it to uncover Polycomb-Lamina antagonism. Big thanks to Allison, Shelby, @MartinAryee, and @liaulab, & to reviewer 1 for the detailed comments. nature.com/articles/s41467-0…
Liau Lab retweeted
How do you get resistance mutations when a drug nearly carbon copies the substrate? 🤔 By distal, allosteric activation! See how we exploit this chemical subterfuge to systematically search for allostery in DNMT1 & UHRF1 in our latest pre-print. 1/N
biorxiv.org/content/10.1101/…
We have another new preprint out! 🎉
keeping the @liaulab 2022 streak alive w/ another preprint out now
tl;dr — we exploit activity-based selection and develop new tools for CRISPR scanning to tackle the difficult task of finding allosteric sites
🧵thread below (1/7):
biorxiv.org/content/10.1101/…
Liau Lab retweeted
Congratulations to Dr. Brian Liau (@brian_b_liau) at @Harvard for being named a 2022 Camille Dreyfus Teacher-Scholar! @liaulab @HarvardCCB
Liau Lab retweeted
We can map DNA-DNA contacts to chart 3D genomes with classic Hi-C, but where are these contacts positioned in the nucleus? Proud to release a new flavor of Hi-C, LIMe-Hi-C, a method that tags & maps DNA-DNA contacts relative to the nuclear periphery! (1/N) biorxiv.org/content/10.1101/…
Liau Lab retweeted
DNMT3A is 1 of the most highly mutated genes in heme malignancies & clonal hematopoiesis with >250 mutations. Ever wonder what mutations in DNMT3A do to its function?🤔 (1/3)
Liau Lab retweeted
Super excited to announce that we’ve just submitted the latest @liaulab ~manuscript~! Tldr: we used base editors + a methylation reporter to do a mutational scan of DNMT3A, a key cancer gene. Highlights below, but check out our preprint at @biorxiv!
biorxiv.org/content/10.1101/…
Liau Lab retweeted
Excited to share our latest work revealing a repressive methylation ceiling in EZH2-mutant lymphoma! We made this discovery by finding drug addiction mutations, a strategy we expect to be broadly useful for uncovering new biology across drug targets. (1/7)
biorxiv.org/content/10.1101/…
Check out our new preprint! Thread here 👇
Epigenetic dysregulation is a cancer hallmark. Restoring the benign epigenetic state is effective therapeutically, but what about pushing tumors further into epigenetic dysregulation? Check out our preprint out @biorxiv from @liaulab to learn more! biorxiv.org/content/10.1101/…
Liau Lab retweeted
Check out this awesome perspective by grad student @steph__rob on exciting work by @lilchromatinboy, @Palgosavi, @brian_b_liau, @liaulab to profile resistance-driving mutations in neosubstrates of molecular glues! Thanks @ACSCentSci for the opportunity!
pubs.acs.org/doi/10.1021/acs…
Liau Lab retweeted
#ASAP by @brian_b_liau & co-workers @HarvardCCB
Profiling the landscape of drug resistance mutations in neosubstrates to molecular glue degraders: go.acs.org/qa
Liau Lab retweeted
Our paper employing CRISPR scanning to profile landscape of resistance mutations in neosubstrates to glue degraders is now online in @ACSCentSci Congrats! @brian_b_liau, @lilchromatinboy, @applecannon23, Cindy, @nicklue8, Jiaming, @sam_hoenig & @liaulab pubs.acs.org/doi/abs/10.1021…
Liau Lab retweeted
aaaaaaand we're officially out in ACS central science
pubs.acs.org/doi/abs/10.1021…
congrats again to @Palgosavi, @brian_b_liau, and the rest of the @liaulab team (@applecannon23, Cindy, Jiaming, @nicklue8, @sam_hoenig)
now please don't ask me to look for missing commas for a week
i never thought i would be in the TPD circles, but here i am, with a new preprint and two cats named pomalidomide and lenalidomide
big shoutout to @Palgosavi and @brian_b_liau for bringing this to life
Liau Lab retweeted
Honored and very grateful for the invaluable funding support from @DamonRunyon.
Congrats to the 2021 Damon Runyon-Rachleff Innovators! Six extraordinary researchers have received five initial grants, and four previous awardees were given “Stage 2” support. Read more about our new #braveandbold Innovators here: bit.ly/3qleTAh and below 🔽
Liau Lab retweeted
(1/4) Molecular glue degraders are captivating drug discovery, but how might drug resistance emerge? Read our new preprint! We identify themes of degrader resistance involving neosubstrates. #TPD biorxiv.org/content/10.1101/…
Honored to have hosted @EsbenSv over the last few months. Hope you had a good time and see you again soon!
Many thanks to @brian_b_liau and all members of @liaulab at @HarvardCCB for hosting my exchange stay over the past ~3.5 months. So much awesome science! It has been a wonderful time in Cambridge. Now looking forward to seeing as much family back in DK🇩🇰 as covid will allow🎄
