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Anastasiou Lab

@AnastasiouLab

Excited about #nature and its inner workings. We are doing research on #cancer, #metabolism, #allostery, #liver and #liver_disease. @ https://teapaw.org/t.co/kgNVXsNP9B

 London, England
crick.ac.uk/research/labs/dimitrios-anastasiou
Joined October 2018
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Photo by Anastasiou Lab (@AnastasiouLab)Photo by Anastasiou Lab (@AnastasiouLab)Photo by Anastasiou Lab (@AnastasiouLab)Photo by Anastasiou Lab (@AnastasiouLab)Photo by Anastasiou Lab (@AnastasiouLab)Photo by Anastasiou Lab (@AnastasiouLab)Photo by Anastasiou Lab (@AnastasiouLab)
The @AnastasiouLab is happy to share our latest paper, led by the outstanding @fiona_grimm, where we explore the metabolic pathways that allow cancer cells to survive during the first few hours in #hypoxia. embopress.org/doi/full/10.10…

Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human...

The EMBO Journal - Adaptation to chronic hypoxia occurs through changes in protein expression, which are controlled by hypoxia-inducible factor 1α (HIF1α) and are necessary for cancer...

link.springer.com
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A timely review on an important topic by @IMalanchi's lab! nature.com/articles/s41568-0…

Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells

Nature Reviews Cancer - In this Review, Rabas et al. describe the mechanisms by which primary tumours precondition distal organs to favour metastatic colonization — a limiting step of...

nature.com
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One of the most lucid Biochemistry textbooks around!
Richard Sever (@cshperspectives) profile pictureRichard Sever@cshperspectives15 Apr 2024
RIP Lubert Stryer - his Biochemistry was my first college textbook, a gift from the lab where I had a summer job
Image from Richard Sever (@cshperspectives)
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Very excited to share this new piece of work - the culmination of a wonderful collaboration with the @sysbiomelab.
The Francis Crick Institute (@TheCrick) profile pictureThe Francis Crick Institute@TheCrick27 Jan 2023
Researchers in the @AnastasiouLab and @sysbiomelab @KingsCollegeLon have built a modelling tool to predict the effects of different diets on cancerous vs healthy cells in mice. Their work could help us better understand the link between diet and disease. crick.ac.uk/news/2023-01-26_…
Researchers map the effects of dietary nutrients on disease

Researchers map the effects of dietary nutrients on disease

Researchers at the Francis Crick Institute and King’s College London have created a tool to predict the effects of different diets on both cancerous cells and healthy cells. 

crick.ac.uk
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...and here is the first author, Frederick Clasen, between his PhD advisors, having just presented his brilliant work before his thesis defence! Great job and thank you and @SaeedShoaie for being such great colleagues!
Image from Anastasiou Lab (@AnastasiouLab)
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Are you a clinician interested in research? Then check out some exciting projects on offer at @TheCrick Doctoral Clinical Fellow's programme: crick.ac.uk/careers-study/cl…
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We are looking for a postdoc to lead an @EPSRC-funded project on the interplay between #metabolism and #signalling using cutting-edge #chemical_biology tools (crick.wd3.myworkdayjobs.com/…). Please RT!
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This project is part of a multidisciplinary #Prosperity_Partnership between @TheCrick & @GSK. For more info: gov.uk/government/news/leadi…, gow.epsrc.ukri.org/NGBOViewG…
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Happy to share our new study @CommsBio (nature.com/articles/s42003-0…). This was a great #collaboration between the @AnastasiouLab @TheCrick & @GSK LinkLabs, driven by our talented postdoc @louise_fets who now has her own lab @MRC_LMS. Look out for Louise‘s forthcoming tweetorial!

MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of...

Communications Biology - Analogs of methyl-oxalylglycine (MOG) were generated as tools to study the monocarboxylate transporter MCT2, an understudied SLC16 family member. These compounds still...

nature.com
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Still some time to apply for this exciting opportunity! Please RT.
Anastasiou Lab (@AnastasiouLab) profile pictureAnastasiou Lab@AnastasiouLab23 Jun 2022
An @EPSRC-funded postdoctoral position is available in our lab to study the interplay between cancer metabolism and signalling using cutting-edge chemical biology tools (crick.ac.uk/careers-study/va…).
An @EPSRC-funded postdoctoral position is available in our lab to study the interplay between cancer metabolism and signalling using cutting-edge chemical biology tools (crick.ac.uk/careers-study/va…).
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This project is part of an exciting multidisciplinary collaboration between @TheCrick and @GSK (gow.epsrc.ukri.org/NGBOViewG…)
Pretty cool initiative by @UCLChemistry! UCL Chemistry team wins award for students’ home science kits | UCL News - UCL – University College London ucl.ac.uk/news/2021/nov/ucl-…
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PhD positions available @AnastasiouLab @TheCrick - check them out and please RT! crick.ac.uk/careers-study/st…
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...incl. a clinical PhD position... crick.ac.uk/careers-and-stud…
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Glad to share this review by @BrinnieSelvaHay, @ilanazed, @ProfRChambers (@UCLrespiratory, @lunglab) that the @AnastasiouLab (@TheCrick) contributed to. stke.sciencemag.org/content/…
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Metabolism has been increasingly appreciated to play important roles in pulmonary fibrosis, a devastating pathological feature of chronic lung disease that will likely also impact patients who suffered from severe #COVID19.
Happy to share an @AnastasiouLab commentary (with @NunesP9) @NatureNV about a beautiful piece of work by @MarcusDGon & colleagues. Call me biased, but the discovery of a new ligand for PKM2 linked to a previously unappreciated physiological phenomenon is pretty awesome!
Nature News & Views (@NatureNV) profile pictureNature News & Views@NatureNV18 Aug 2021
Feeding mice high-fructose corn syrup drives an increase in the surface area of the gut that is associated with enhanced nutrient absorption and weight gain. Learn more in a super N&V by Patrícia Nunes & @AnastasiouLab @TheCrick go.nature.com/3sFDK1z
Image from Nature News & Views (@NatureNV)
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An exceptional and inspirational lecture by Ernst Hafen - youtu.be/lhK0e23_5KY
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Join us for the third session of this exciting talks series! Tomorrow, Tuesday, 4pm, UK time
ISCaM -International Society for Cancer Metabolism (@ISCaM_Society) profile pictureISCaM -International Society for Cancer Metabolism@ISCaM_Society9 Nov 2020
Replying to @ISCaM_Society @jer_06200
#ISCaM2020 - 'Systemic Metabolism and Cancer' - we are going live again, covering Metabolic Disease and Cancer with four talks: Marco @LabSandri, Paolo Porporato @LabPorpo, Andrew Dannenberg @WeillCornell, Stephan Herzig @helmholtz_diabc. Program/Zoom: drive.google.com/file/d/1On-…

The ISCaM2020 webinar program.pdf

drive.google.com
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This is a really cool piece of work! Illuminating a widely-used drug's (true) mode-of-action is exciting!
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Interesting choice of words for the title.... Ten people who mattered in science in 2019. nature.com/articles/d41586-0…
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@AnastasiouLab X-mas lunch at the Crick together with our dear colleagues from the Yuneva lab.
Image from Anastasiou Lab (@AnastasiouLab)
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Celebrating @aakritijain24, the newest PhD from the @AnastasiouLab, with her examiners, @FrezzaLab and Michael Munday just after the viva - congratulations, Aakriti! @Meta_RNA
Image from Anastasiou Lab (@AnastasiouLab)
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Exciting new insights into how cells control their division! And a brilliant demonstration of how single-cell studies can transform the way we (re-)view fundamental phenomena in biology!
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