I downloaded and plotted hourly data for approximately 100 years for many different tide gauges. Every hour is incorporated in these graphs. The trend is essentially linear for every single one. No cherry-picking. We are coming out of an ice age. Thus many stations show a few millimeters per year of increasing sea level and some show a few millimeters per year of decreasing sea level because ice is retreating and the continents are uplifting near polar regions. As far as I can tell there is no sea-level catastrophe and those who say so don't have data to back it up: That is, they are scamming.

Announcing Prosperity One: a proposed 6.6 gigawatt nuclear campus in Lewis County, Kentucky

1/ Today we’re unveiling Bombadil, @electricplantco's foundation model that reads the electrical signals of living plants and turns them into a continuous view of their physiology. Trained on 7M+ hours of plant electrical signal across 125+ species. That makes Bombadil the most species-diverse model of directly recorded electrical biosignals in existence. The animal equivalent would be one model that reads the brainwaves of blue whales, horseshoe crabs and fruit flies.

A few years ago, Effective Altruists decided to place "moral weights" on human lives. They say that humans are worth about two pigs or three chickens. These are the kind of models that will guide the distribution of funds through Anthropic's "public good" operation.

Can we design proteins that cut other proteins? Our de novo cysteine protease paper is out in Nature! We designed new folds that cleave peptide backbones, with activity demonstrated in mammalian cells. Paper and code 👇 nature.com/articles/s41586-0…

Unfortunately a large amount of the world lives in and believes in absolute barbarity, and the mandate of Western civilization is not just to eliminate this from our societies but banish barbarism from the face of the earth forever.

People forget that the case against Elizabeth Holmes included black-and-white "lying about revenue"-type financial fraud

Has anyone put a team of ~10,000 agents on fusion reactor design, especially for something like a stellerator? Feels like the kind of optimization problem they would excel at. Clear metrics, can be iterated on purely in simulation

99% of women and girls in Somalia have been mutilated in the following way: the clitoris is cut off, along with the inner labia. Then the inner flesh of the outer labia is removed before both sides are sewn tightly together, leaving a hole no bigger than a matchstick for urine and menses to trickle through. All of this is done in childhood, and without any form of anesthesia whatsoever. Sometimes the little girl is given a scrap of leather or a stick to bite down on. The cutters use old razor blades, or sometimes a piece of broken glass. This is only the beginning of a girl’s pain. Most wedding nights in Somalia are aided by “the little knife” — that is, the new husband slices his bride open so that he can penetrate her now cut and bleeding scar tissue. Some men, however, simply batter their way through, tearing that tiny hole open by sheer force. When a woman goes into labor, she’s cut open more widely, then sewn back up afterwards so that when sex resumes she will have to be cut open yet again. This practice leads to countless deaths from infection and a drastic increase in maternal mortality, but Somali men still refuse to marry uncut women, forcing mothers to have their daughters cut or face social stigma. Uncut girls are seen as dirty; the term for clitoris is a playground taunt in Somalia, and girls who are not cut are usually ostracized by their peers. The Somali government recently debated the legality of this appalling custom, and the parliament largely split along gender lines. Female MPs roundly condemned FGM, while male MPs insisted that having a clitoris made a woman more difficult to penetrate, and quoted the hadith in which Muhammad condoned the practice. These are educated men who nevertheless claim that cutting a girl is necessary in order to control her sexuality, and that an uncut woman will be promiscuous and untrustworthy. In spite of the Somali government’s continued support for FGM, foreign aid continues to flow into Somalia unobstructed. The West should refuse to give the Somali government so much as a single dollar until they outlaw FGM and take positive steps to combat the problem. One tactic that has been highly successful involves showing Somali men a video of a girl being mutilated. Because FGM is seen as women’s business, most men have no idea what it entails. Men who watch this video are horrified, and the most common reaction has been “Not my daughter!” This proves that FGM is not hopelessly entrenched in Somali culture. Western pressure and resources could make an enormous difference in the lives of Somali women and girls, and put a stop to this barbaric practice.

You can design the next Ozempic for free on challenge.ligandai.com and get your designs submitted for wet lab validation via the @adaptyvbio x @AnthropicAI @proteinbase competition.

Premières tensions sur la place de la Bastille. Charge de la police après de nombreux jets de projectiles. #blocuslycees #blocusuniversites #Paris #8octobre