🧠 Late-Onset Unprovoked Seizures and Subsequent Dementia Risk Our new study in Seizure: European Journal of Epilepsy @SeizureJournal examines the association between late-onset unprovoked seizures of unknown etiology and subsequent dementia-related outcomes in older adults. Using federated data from the TriNetX Global Collaborative Network within a target trial emulation framework, we analyzed 80,802 propensity score–matched individuals. Late-onset unprovoked seizures were associated with higher subsequent risks of all-cause dementia, Alzheimer disease, vascular dementia, and mild cognitive impairment, with the strongest association observed for vascular dementia (HR 2.07). These findings describe an observational association, not causality, and raise a broader question: whether late-life unprovoked seizures may represent an early clinical marker of underlying neurodegenerative or cerebrovascular disease. Further longitudinal studies integrating seizure phenotyping, biomarkers, and neuroimaging will be needed to clarify this relationship. My sincere thanks to Prof. George Perry @geoperry and to Daniel V. Lima Jr., Leonardo J.C. Cardoso, Gabriel C.N. Tudella, Alice M. Lee, Marina Costa, Cristine M. Cukiert, Gustavo S. Noleto, and Diogo H. Santos for their collaboration and contributions to this work. Seizure. 2026 seizure-journal.com/article/…

🧠 The Circadian Clock in Glioblastoma: Mechanisms and Therapeutic Potential Our new review in Clocks & Sleep examines the emerging relationship between circadian biology and glioblastoma, with particular attention to molecular mechanisms and potential therapeutic implications. Circadian rhythms regulate a broad range of physiological processes, and increasing evidence suggests that disruption of the molecular clock may also influence glioblastoma initiation and progression. In this review, we discuss alterations in core circadian genes, their potential involvement in glioma biology, and whether restoring circadian regulation could contribute to tumor control. We also explore chronotherapy as a potential therapeutic strategy. Aligning chemotherapy and radiotherapy with individual biological rhythms may offer a way to optimize treatment response while accounting for temporal variation in tumor and host physiology. Current evidence remains largely mechanistic and exploratory, and further experimental and clinical studies are needed before circadian-based strategies can be incorporated into routine glioblastoma care. I am pleased to have contributed to this work alongside Samaneh Ghorbani Shirkouhi, Farzin Kamarii, Poul Flemming Høilund-Carlsen, Morten Blaabjergjerg, Abass Alavi, Frantz Rom Poulsenen, Mona-Elisabeth R. Revheim, and Sasan A. Clocks & Sleep mdpi.com/2624-5175/8/4/59 #Glioblastoma #Neuroscience #NeuroOncology #CircadianRhythm #Chronotherapy #CancerResearch #BrainTumor #TranslationalResearch

🧠 New paper in Neurological Sciences with Diogo Haddad Santos: Amyloid-beta-targeting monoclonal antibodies in early Alzheimer’s disease: a Cochrane review summary and appraisal for the neurological community Building on the recent Cochrane review, we examine how class-level estimates should be interpreted alongside agent-specific evidence on efficacy, ARIA risk, target engagement, and clinical relevance. A central message is that pooled class effects should not be assumed to represent individual antibodies such as lecanemab or donanemab. We acknowledge the Cochrane Neurological Sciences Field @SpringerNature, the editorial team of Cochrane Review CD016297, @cochranecollab, and @cochranecollab for the evidence synthesis that provided the foundation for this critical appraisal. 📄 link.springer.com/article/10… 📖 cochranelibrary.com/cdsr/doi… #AlzheimersDisease #Neurology #Dementia #Cochrane

🧠 Epilepsy and Subsequent Dementia in Adults with Down Syndrome Our new study in Seizure: European Journal of Epilepsy @SeizureJournal examines the temporal relationship between epilepsy and subsequent dementia in adults with Down syndrome. Using federated data from the TriNetX Global Collaborative Network, we found that epilepsy was associated with approximately twice the subsequent rate of all-cause dementia and Alzheimer disease after propensity score matching. The association remained consistent across age and sex strata and under a more restrictive definition of epilepsy. These findings establish a temporal, not causal, association and raise an important question: whether epilepsy may represent part of the clinical trajectory of Alzheimer-related neurodegeneration in Down syndrome. Further longitudinal studies integrating clinical phenotyping, biomarkers, and neuroimaging will be needed to address this question. My thanks to Prof. @geoperry , Gabriel Tudella, Alice Mi Lee, Diogo Haddad Santos, and Cristine Mella Cukiertfor their collaboration. Seizure. 2026;142:220–229. seizure-journal.com/article/…

Pleased to share my appointment as Reviews Editor of the @journal_ad . I look forward to contributing to the journal’s editorial work and to rigorous scholarship in Alzheimer’s disease and neurodegeneration. Grateful to the colleagues and collaborators who have been part of this journey. #AlzheimersDisease #DementiaResearch #Neurodegeneration

Pleased to share our new systematic review and meta-analysis, published in the Journal of Clinical Psychopharmacology, on alpha-lipoic acid as an adjunctive therapy for schizophrenia. pubmed.ncbi.nlm.nih.gov/4253… Grateful to all co-authors for their rigorous and thoughtful collaboration. @JCPjournal

🔬 Pleased to share our new article in Psychiatry Research. In this propensity-matched cohort study using electronic health record data, we compared low-dose lithium with valproate in older adults, focusing on incident dementia diagnoses, mild cognitive impairment, and selected safety outcomes. sciencedirect.com/science/ar… @geoperry @alzforum @PsychiatryResJ @LeonardoC_MD @diogohaddad @tarokishi @danielsiqueira

I am pleased to share the publication of our article in Drugs & Aging: Gabapentinoid Use and Risk of Alzheimer’s Disease-Related Dementias: A Systematic Review and Meta-analysis of Observational Studies In this systematic review and meta-analysis, we examined the observational evidence on gabapentinoid use and the risk of Alzheimer’s disease-related dementias. link.springer.com/10.1007/s4… @alzforum @geoperry @SpringerNature

Pleased to share our new article in the American Journal of Geriatric Psychiatry. We systematically reviewed and meta-analysed the clinical evidence on cannabinoid-based therapies for agitation in Alzheimer’s disease, with attention to efficacy, safety, and certainty of evidence. sciencedirect.com/science/ar… @alzforum @geoperry

From hope to uncertainty: regulating novel drugs for Alzheimer's disease - The Lancet thelancet.com/journals/lance…

I am pleased to share the publication of our article in Drugs: 💊📚 Use of Sedative-Hypnotic Drugs and the Risk of Developing Alzheimer’s Disease: A Systematic Review, Meta-Analysis and Meta-Regression In this systematic review with meta-analysis and meta-regression, we examined the observational evidence on sedative-hypnotic drug use and Alzheimer’s disease. The synthesis suggests a higher estimated odds of Alzheimer’s disease among users of these medications. I am grateful to all co-authors for their collaboration throughout this study. link.springer.com/article/10… @SN and #SNAuthor @PreventAD @AlzSocResearch @alzforum

Now in press in the Journal of Alzheimer’s Disease: “Methodological considerations on the network meta-analysis of brexpiprazole dosing for agitation in Alzheimer’s disease.” In this Letter, we discuss relevant methodological and clinical aspects for interpreting a network meta-analysis of different brexpiprazole doses for the management of agitation associated with Alzheimer’s disease. @DiogoHaddad @journal_ad journals.sagepub.com/doi/10.…

Causes of death in patients with dementia: A study in a geriatric hospital in São Paulo, Brazil - Yngrid Dieguez Ferreira, Carolina Braga Moura, Amanda Carneiro Rodrigues, Anderson Matheus Pereira Da Silva, Diogo Haddad Santos, Maria Fernanda Mendes, 2026 journals.sagepub.com/doi/abs… @journal_ad @alzforum