32 minutes with AI vs. an estimated several months to a year of human analysis and literature review.
OpenAI, PerturbAI, and Scripps Research used thousands of GPT-Rosalind agents to analyze data from millions of mouse brain cells.
Replying to @OpenAI
In the same mouse-brain dataset, GPT-Rosalind found a possible clue to why TSC2 mutations tend to cause more severe tuberous sclerosis than TSC1 mutations.
The two genes work together to regulate mTOR. Yet in one group of cerebellar neurons, disrupting TSC2 changed the expression of dozens of genes, including genes involved in neuronal communication. Disrupting TSC1 had little effect on gene expression in the same cell type.
Existing treatments already target mTOR. Do they reverse these changes, or is there more to TSC2’s role in these neurons?
OpenAI is proposing a five-stage process for responding to critical security vulnerabilities, coordinating fixes with maintainers, security providers, and government agencies before public disclosure.
The company has also committed $1 billion in subsidized Daybreak access to help security organizations protect essential services.
AI just helped uncover critical vulnerabilities in PHP, which powers an estimated 70% of websites.
The fixes took two months and required a major change to the PHP engine.
OpenAI models helped researchers—operating as part of our Patch the Planet initiative—discover critical security flaws in PHP, an open-source programming language used to run an estimated 70% of websites.
Over the past two months, we led a coalition of maintainers, researchers, and security providers to prepare fixes and protections ahead of disclosure. This duration was necessary because the fix was quite intricate and required a major change to the PHP engine. Every site using PHP can now safely upgrade their version to stay secure, in addition to applying mitigations from various security vendors.
Due to the severity of these flaws and PHP’s widespread use, we consider this bug to be one of the most impactful vulnerabilities in recent memory. It also marks a new phase, where AI can find security bugs with internet-scale impact.
This is an example of the Defender’s Window in action: to our knowledge, frontier AI was able to find this vulnerability ahead of attackers, giving defenders time to prepare.
openai.com/index/coordinated…
Readers added context they thought people might want to know
Wiz Research wasn't the first one to discover the exploit. An independent researcher first discovered it: x.com/calif_io/statu…
The biggest breakthrough of @thsottiaux's 28-day challenge so far.
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