Immunologist at UCL
UCL, London
Joined March 2009
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Can now run the whole pipeline using a single command. Much faster and more memory efficeint.
For all the T cell receptor sequencers out there, the latest version of our analysis pipeline Decombinator 5.0 is live, and now on PiPy for greater ease of installtion ! Thanks to Matt Cowley for a huge amount of work !
pypi.org/project/decombinato…
For all the T cell receptor sequencers out there, the latest version of our analysis pipeline Decombinator 5.0 is live, and now on PiPy for greater ease of installtion ! Thanks to Matt Cowley for a huge amount of work !
pypi.org/project/decombinato…
Benny Chain retweeted
We are delighted to announce that Professor Edith Heard has been appointed as our new director and chief executive!
Edith, who is currently director-general at @EMBL, will succeed Paul Nurse in leading the Crick from the summer of 2025.
🔗 crick.ac.uk/news/2024-07-09_…
ALT "The Francis Crick Institute has quickly established a global reputation for its work at the frontiers of science. I relish the challenge of building on that work. I also want to pay tribute to Sir Paul Nurse, without whom the Francis Crick Institute would not be the world-leading institution it is today." - Edith Heard
Single cell analysis of the phenotype of bonemarrow T cells in myeloma reveals striking phynotypic differences from solid tumour TILS. Read our latest paper out here medrxiv.org/content/10.1101/…
Benny Chain retweeted
Are you a PhD graduate in Physics, Chemistry, Earth Science, Math or Computer Science?
Apply for the Max Planck-Weizmann Joint Postdoctoral Program. Includes a fully funded four-year position, split equally between these two esteemed institutions >> bit.ly/mpg_wis
Benny Chain retweeted
New major team preprint demonstrating antibodies from #longCOVID patients are sufficient to cause pathology and behavioral symptoms when transferred to mice. Importantly, they match individual patient symptoms to potential autoantigen targets and induced mouse behaviors
Sharing our new study by @keylas3, @SilvaJ_C, Rafael Bayarri Olmos et al (with T. Horvath & @PutrinoLab) showing that a passive transfer of IgG from patients with #longCOVID into mice recapitulates ⬆️ pain and other symptoms 🧵 (1/)
medrxiv.org/content/10.1101/…
Benny Chain retweeted
We're hiring! Are you a lab scientist interested in human immunology of infectious disease, using cellular models of host-pathogen interactions and human experimental challenge, focusing on immune responses in Tuberculosis and SARS-CoV-2? Apply here: bit.ly/3yPdfO5
The latest exciting step forward in T cell receptor representation ! @YutaNotUtah outperforms TCR-BERT ! arxiv.org/pdf/2406.06397
We are looking for a research fellow interested in the T cell receptor repertoire to work on some amazing cancer data sets. Check out this job at UCL: linkedin.com/jobs/view/39304…
Benny Chain retweeted
How do interactions between hypervariable loops shape TCR specificity? Can patterns of sequence co-variation help us pair alpha-beta chains using techniques developed for co-evolving proteins?
New work led by @Martina_Milig now out on bioRxiv! 👇
New preprint!
We investigated the molecular interactions between the TCR CDR loops and find that these may be important in shaping TCR specificity and sequence
biorxiv.org/content/10.1101/…
Martina's elegant new paper defines an important and under-appreciated role for molecular interactions between CDR loops of the TCR !
Intra- and inter-chain contacts determine TCR specificity: applying protein co-evolution methods to TCRαβ pairing biorxiv.org/cgi/content/shor… #biorxiv_immuno
Benny Chain retweeted
OUT NOW 📢: A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting @zgitai1
nature.com/articles/s41564-0…
Benny Chain retweeted
So excited for our latest story on a tunable-spectrum antibiotic to be published. We desperately need microbiome-sparing strategies to treat P. aeruginosa. Amazing effort led by the fantastic @ConnorChain
OUT NOW 📢: A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting @zgitai1
nature.com/articles/s41564-0…
Benny Chain retweeted
Lightning-fast adaptive immune receptor similarity search by symmetric deletion lookup
arxiv.org/abs/2403.09010
In work led by @heartnetkung we show how an algorithmic paradigm from spell checking can accelerate TCR clustering by orders of magnitude
Benny Chain retweeted
Three weeks left to apply to our open-rank search in AI & Infection! Come join us at @UCLInfectImm 😀
Group Leader in Infection & Artificial Inteligence @UCLInfectImm
New post to strengthen AI & computational approaches to Infection Biology. Linking with world-class expertise @UCL bioscience, population sciences, computer science & structural biology tinyurl.com/3mpsu7pk
Benny Chain retweeted
The Arthur and Sandra Irving Cancer Immunology Symposium
Website: irvingcancerimmunologysympos…
Hosted by Arthur and Sandra Irving symposium (from Jun 24-27, 2024 in Boston) will focus on advancing the careers of young scientists doing research in cancer immunology. Apply!!!
Benny Chain retweeted
Glad to announce that our QImmuno lab approach for TCR-pMHC specificity prediction just won silver and bronze medals in the IMMREP23 benchmark! 🥳
kaggle.com/competitions/tcr-…
This seems a cool paper - proteins in the shapes of letters or digits !! nature.com/articles/s41586-0…
Benny Chain retweeted
💥BIG PAPER ALERT💥 So excited to share our latest, out now @Nature! Here, we uncover a spatially confined interplay between subsets of IL-1b+ macrophages and tumor cells that fuels pathogenic inflammation in pancreatic cancer (1/n)
nature.com/articles/s41586-0…
