Biochemical engineer, PhD medical science @karolinskainst and @ugent, #ProstateCancer, #LiquidBiopsy & @ProBioTrial researcher. Views are my own
Ghent, Belgium
Joined November 2016
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Bram De Laere retweeted
Accrual is fast, now with Finland and Denmark added, it will go even faster! If pharma is interested, @ProBioTrial is looking for new molecules to be tested!
Bram De Laere retweeted
What did @ProBioTrial prove in mCRPC? What can you do with the info of a liquid biopsy? From a concept starting in 2019 to practice informing data from PFS, OS and QoL (out soon) data.
Bram De Laere retweeted
💡However, comparative randomised evidence is available from the ProBio trial (NCT03903835) in men with ARPI-naïve mCRPC and detectable ctDNA. Compared to taxanes, ARPIs were associated with:
✅ Longer time of clinical benefit (PCWG3)
✅ Longer overall survival
✅ Fewer (S)AE
Bram De Laere retweeted
📣 Pleased to share the publication of the ProBio-mHSPC trial protocol in @EUplatinum Focus: a ctDNA-driven platform trial designed to personalize treatment intensity for patients with metastatic hormone-sensitive prostate cancer.
🤖 Made with AI
Bram De Laere retweeted
On the eve of #ASCO25, I am delighted to share results from the correlative analyses of the @ANZUPtrials phase II TheraP study, now published in @NatureMedicine. Massive effort supported by dedicated co-investigators, coordinators, patients & families from 11 study sites across Australia 🙏🏼 🧵1/10
nature.com/articles/s41591-0…
Bram De Laere retweeted
But if you ask the companies @Merck to provide drug for a biomarker selection trial like @ProBioTrial, they refuse. Even if you ask for compassionate use for PCa MSI high in the trial!!! @BramDL
Bram De Laere retweeted
📢 STORM trial breaking results at #ESTRO25!
🧪 MDT vs ENRT+MDT for nodal oligorecurrent PCa.
🧬 ENRT+MDT:
✅ Superior bRFS (57% vs 41%, p=0.014)
✅ Superior pelvic control (lrRFS 85% vs 62%, p=0.006)
✅ Superior MFS (76% vs 63%, p=0.06)
❌ No increase in ≥G2 GU/GI toxicity
Bram De Laere retweeted
🏅Secondary result:
We found a linear relationship between ctDNA 🩸 levels and outcome:
📉 Every 10% increase in ctDNA fraction led to a 9% decrease in the observed survival time.
💡 The more ctDNA in🩸, the worse the outcome!
#PrecisionMedicine
[5/8]
Bram De Laere retweeted
🏅Key result:
🧬🩸 Compared to those with detectable ctDNA, men with undetectable ctDNA had
➡️a 60% longer time before treatment stopped working (time to no longer clinically benefiting, NLCB)
➡️a 51% longer overall survival (OS) 📉
#CancerBiomarkers
[4/8]
Bram De Laere retweeted
🚨 New Study Alert! 🚨
What if a blood test 🩸 could infer prognosis in advanced prostate cancer? Our latest #ProBio trial study reveals the prognostic power of circulating tumor DNA (ctDNA) 🧬 in #mCRPC
A thread 🧵👇 #CancerResearch #ProstateCancer
[1/8]
Bram De Laere retweeted
Important work from the ProBio team! Proud to be a contributor. #probio #prostatecancer
@BramDL @piet_ost @ReneeBultijnck
eur03.safelinks.protection.o…
Bram De Laere retweeted
AR pathway inhibitors vs taxanes in #mCRPC #ProBio trial. @BramDL @ugent joins @zklaassen_md @GACancerCenter to discuss the #ProBio trial, a groundbreaking platform study in metastatic prostate cancer. Findings show that AR pathway inhibitors often outperform taxane-based chemo in mCRPC, with outcomes influenced by specific genomic markers. #WatchNow > bit.ly/3YXuh6j @ProBioTrial
Bram De Laere retweeted
That makes zero sense. And a quote from Edison makes it right. Doing 10.000 trials will induce a ton of financial harm, toxicity and delay the development of other strategies.
'FIRST, DO NO HARM'. Thomas Sydenham.
Bram De Laere retweeted
Don’t forget the @ProBioTrial is an investigator-initiated trial! Crazy level of commitment of everyone involved.
Meet the @ProBioTrial consortium: healthcare professionals from 🇸🇪🇧🇪🇳🇴🇨🇭specialised in the treatment of men with metastatic #ProstateCancer
They made the 🥈#ProBioTrial International Investigator’s Meeting a success 🙏
Presentations soon available on probiotrial.org
Bram De Laere retweeted
Meet the @ProBioTrial consortium: healthcare professionals from 🇸🇪🇧🇪🇳🇴🇨🇭specialised in the treatment of men with metastatic #ProstateCancer
They made the 🥈#ProBioTrial International Investigator’s Meeting a success 🙏
Presentations soon available on probiotrial.org
Bram De Laere retweeted
Prof. Henrik Grönberg opening the 2nd #ProBioTrial International Investigators Meeting in Stockholm! 🌍
Healthcare professionals from 🇸🇪 🇧🇪 🇳🇴 🇨🇭 are coming together to push the boundaries of #ProstateCancer cancer research and treatment.
Let’s make an impact! 💪
Bram De Laere retweeted
@ProBioTrial first results on HRD altered mCRPC. Can we ⚰️ Carboplatin for #prostatecancer? No benefit for any of the subgroups.
