PCF Science retweeted
UCLA Urology has a long history of impactful basic science discoveries, clinical innovation, practice-changing trials, FDA drug/imaging approvals, and mentorship of future leaders.
We are hiring a Vice-Chair of Research: recruit.apo.ucla.edu/JPF1131…
DM if questions/nominations
PCF Science retweeted
Thank you, @EAntonarakis ! Truly honored and grateful to @PCF_Science and the Milken Family Foundation. Thank you for your mentorship, alongside Justin Hwang and @DrJustinDrake , and to the patients who make this work possible. Excited for what's ahead! @UMNCancer
Congrats to our newest PCF Young Investigator from Minnesota, the one-and-only Dr. Ali Arafa @aliarafaa. @UMNCancer @UMNews @ThePCCTC @PCF_Science
PCF Science retweeted
Pushing Terbium-161 PSMA Theranostics to 9.5 GBq - VIOLET Clinical Trial results at the #EANM26 @EANM_NucMed
Terbium-161 emits beta radiation like lutetium-177, plus ultra-short range Auger and conversion electrons that may better target micrometastases. Our first-in-human VIOLET trial established safety up to 7.4 GBq (Lancet Oncology 2025).
So we asked: can we go higher? 12 men with mCRPC, 9.5 GBq, up to 6 cycles:
- Remarkably well tolerated: just 1 grade 3 toxicity (anaemia)
- PSA50 response 75%, PSA90 response 33%
- Median PSA-PFS and rPFS not reached
The answer is yes - and we’re not stopping ... Cohort C, a dose-dense cohort with shorter intervals between early cycles, is now underway.
Huge thanks to @PCF_Science Young Investigators @ButeauJames , @LouiseKostos and @AzadOncology , and to the whole @PeterMacCC @pros_tic team who made this investigator-initiated trial possible.
Grateful to @Isotopia_Global and the for their support
#TOP (Top Rated Oral Presentation)
PCF Science retweeted
🚨 Focal salvage HDR brachy for radiorecurrent #prostatecancer🚨
📜@JCO_ASCO
👥 n=62, intraprostatic radiorecurrence after prior RT, multi-institutional
📊 Phase 1/2, dose-escalated focal salvage HDR, up to 30 Gy in 1 to 2 fractions
⏱️ Median f/u 39.4 mo
✅ No acute grade 3 toxicity; late grade 3 in 2 pts (3.2%)
✅ 3-yr bPFS 62.7%, MFS 85.9%
✅ Higher Decipher GC score tracked w/ worse bPFS, rPFS, MFS; all 4 pts w/ GC >0.85 recurred
⚠️ Small GC subset (n=31), single-arm, hypothesis-generating
🎯 Focal salvage HDR is well tolerated & a genomic classifier may prognosticate
🔗 doi.org/10.1200/JCO-25-02730
@UroOnc @urotoday @UrologyTimes @PCF_Science @Davicioni
PCF Science retweeted
Congratulations to @DanaFarber's Mary-Ellen Taplin, MD, who was honored with the @PCFNews Women in Science Lifetime Achievement Award. @DanaFarber_GU
Read more: bit.ly/4zj9nPh
PCF Science retweeted
Exciting opportunity for Urology & med onc trainees and practicing physicians👉Elevate your clinical and leadership skills at the @PCFnews Leadership Academy! 📍Santa Monica | Dec 3–5, 2026
✅ Expert faculty mentoring ✅ Formal certification
✅ Travel & hotel covered 👉Apply: bit.ly/4dyRWlv @urotoday
PCF Science retweeted
Not all prostate cancers follow the same molecular playbook! 🧬
🚨🚨Excited to share our new work in @CellReports, spearheaded by graduate student @RizwanKinza 👏and medical student Sai Manikonda👏, revealing distinct genomic alterations and transcriptional programs associated with SPOP-mutant prostate cancer. Another step toward more biologically informed precision oncology! @BCMFromtheLabs
Above all, grateful to the patients who generously contributed their biospecimens to advance cancer research. 💕
A heartfelt thank you to our collaborators for their hard work, support, and invaluable feedback throughout this journey. @CCoarfa @marthamims
And a special shout-out to the often-unsung heroes of science—our reviewers! Their thoughtful and constructive feedback made this a stronger manuscript. 💕
Proud of this team and grateful for the support of @BCMDeptMedicine @bcmhouston, @PCF_Science, CDMRP PCRP and @NIH @theNCI
🔗cell.com/cell-reports/fullte…
PCF Science retweeted
This work was funded by @fredhutch, @theNCI, @PCFnews @PCF_Science, @AmericanCancer, @CDMRP, the Larry & Virginia Gordon Endowed Chair, and the Mathews Family, Stinchcomb Family, and Thomas & Patricia Wright memorial funds.
PCF Science retweeted
Of note, @yeonsookim_phd (@theNCI K99/R00 awardee) is on the academic job market, so keep an eye out for her. She is an outstanding RNA and cancer biologist!
PCF Science retweeted
Ever wonder if tRNAs can regulate the identity of a cancer cell?
@HsiehLab @FredHutch postdoc @yeonsookim_phd did and discovered a single tRNA that can control lineage dependency and drug sensitivity in prostate cancer published today @Nature: nature.com/articles/s41586-0…
PCF Science retweeted
What an inspiring few days at the Prostate Cancer Foundation Annual Scientific Retreat! 🔬🌍
We were so proud to present two new CRIS Cancer–PCF Young Investigator Awards to Kirsty Hodgson (Newcastle University) and Nicolás Anselmino (VHIO). 🏆
#ProstateCancer
PCF Science retweeted
ARIEL trial: 📄 and🧵on MRI🧲 changes with RT+ADT for #ProstateCancer 👇🏼
@OncoAlert @UroToday @imagingprostate @ASTRO_org @PCF_science @MedwatchHQ #practicalRO #ASTRO26
@adornisch_MD @DrRanaMcKay @medmund14 @UCSDRadMed @DrTylerStewart @UCSDCancer
New in #practicalRO: Androgen Deprivation Therapy (ADT) and Radiotherapy (RT) with Imaging Evaluation Longitudinally (ARIEL) Trial: Protocol, Early Results, and Implications of Neoadjuvant ADT for Focal RT Boost in Prostate Cancer. This article was presented during #ASTRO2026 in Quick Pitch Session 22.
PCF Science retweeted
8️⃣ end
🙏🏼Patients who got in the 🧲 tube for research
🙏🏼Physicians who enrolled patients
🙏🏼Research team for consenting and collecting data
🙏🏼@ASTRO_org @PCF_Science for funding the trial
PCF Science retweeted
Honored to give my first presentation as a PI at a fantastic Keystone Symposium, “Hormonal influences on immunity and cancer across the lifespan” organized by Suzanne Conzen, Amy Moran, and James DeGregori.
PCF Science retweeted
This account is hacked, in case anyone is wondering why “Howard Soule” has suddenly begun spewing out financial “advice.” Unfollow and find the real Dr. Soule on LinkedIn instead.
unavailable
PCF Science retweeted
The world’s leading prostate cancer researchers came to Carlsbad to share their work, and patients and caregivers came with the questions that matter most.
For 33 years, PCF has brought science and lived experience together to move research forward.
#PCFRetreat26
PCF Science retweeted
How many scientists study #ProstateCancer because of Howard Soule?
How many collaborations originated with an intro from Howard?
How many lives have been touched by this wonderful man?
Thank you, Howard!
@PCF_Science tribute to Howard!
#PCFRetreat26
PCF Science retweeted
Does RB1 loss influence tumor metabolism and sensitivity to metabolic inhibitors? @DanielFrigo discussed at PCF and collaborated with Dr. Ana Aparicio @UTMDAnderson
PCF Science retweeted
Dr. Himisha Beltran of @DanaFarber Cancer Institute takes the stage at #PCFRetreat26 to spotlight the power of academic-industry partnerships to drive innovation, accelerate discovery and bring new treatment approaches to patients faster. #ScientificRetreat
PCF Science retweeted
At the Dr. Felix Feng Legacy Lecture at #PCFRetreat26, Joshua Lang, MD, shares “50 Lessons in Life, Leadership, and Science that Matters,” honoring Dr. Feng’s legacy while inspiring the next generation of physician-scientists.
#ScientificRetreat
