@HsiehLab

A lab @FredHutch obsessed with translation control and its impact on health and disease. #mRNAtranslation #prostatecancer #bladdercancer #physicianscientist

 Seattle, WA
research.fhcrc.org/hsieh/en.html
Joined January 2019
  • Tweets4.2K
  • Following609
  • Followers2.1K
75Media
Ever wonder if tRNAs can regulate the identity of a cancer cell? @HsiehLab @FredHutch postdoc @yeonsookim_phd did and discovered a single tRNA that can control lineage dependency and drug sensitivity in prostate cancer published today @Nature: nature.com/articles/s41586-0…

tRNA dosage regulates lineage dependency and resistance in prostate cancer

Nature - A tRNA-specific regulatory pathway is associated with codon biology, lineage transitions and therapy resistance in prostate cancer.

nature.com
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A study shows that a single tRNA helps determine if #ProstateCancer remains treatment-sensitive or becomes resistant, opening new avenues in #PrecisionOncology. 🥼Abstract by Drs. Yeon Soo Kim & Andrew Hsieh at @fredhutch: go.nature.com/4sdNgY8 📰News: bit.ly/4yY0N8P
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Hsieh Lab retweeted
Hao Zhu Lab@Zhu_LabOct 19
We are looking to hire post-doctoral fellows to work on somatic mosaicism, regeneration, and cancer development, please reach out to me if you are interested! @CRI_UTSW
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Ready to lead the next wave of discovery in precision oncology? Fred Hutch is recruiting a Faculty Position, Bezos Family Distinguished Scholar in Precision Oncology within the Human Biology Division. Apply today: apply.interfolio.com/193908
Exterior view of the Fred Hutch Cancer Center building on a sunny day. The image includes text that reads, "We're hiring! Bezos Family Distinguished Scholar in Precision Oncology.

ALT Exterior view of the Fred Hutch Cancer Center building on a sunny day. The image includes text that reads, "We're hiring! Bezos Family Distinguished Scholar in Precision Oncology.

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Scientists in the @HsiehLab at Fred Hutch Cancer Center found that the molecular regulator RNA—specifically tRNA, a type of RNA—may be able to influence the nature of prostate cancer cells and how they respond to treatment. Via @Newsweek bit.ly/3UjeKz9

Scientists find potential weak spot in aggressive, drug-resistant cancer

Scientists identified a driver of aggressive prostate cancer and a potential way to stop drug-resistant tumors forming.

newsweek.com
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Hsieh Lab retweeted
Hani Goodarzi
@genophoriaOct 9
What is fascinating about academia as a career is that there are certain ideas that you have been working on since you remember. The numerical optimalities of the genetic code is what drew me to biology in the first place. I ended up working on codon usage as grad student and tRNAs as a postdoc, as the language layer on top of the genetic code. And now, 25 years later, I’m still amazed by how under-explored this field remains. So, new preprint with Vijay Ramani 🧵
Arc Institute
@arcinstituteOct 9
Hundreds of human tRNA genes form a redundant repertoire for decoding the genetic code. But does redundancy imply functional equivalence? A pan-cancer in vivo CRISPRi atlas from @genophoria and Vijay Ramani at @GladstoneInst reveals a structured landscape of tRNA dependencies.
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tRNA Influences If Prostate Cancer Becomes Resistant to Treatment A single tRNA can influence whether prostate cancer cells mutate and become difficult to treat with standard therapies @HsiehLab @fredhutch #prostatecancer #tRNA #cancertreatment hubs.ly/Q04zt1cF0

tRNA Influences If Prostate Cancer Becomes Resistant to Treatment

A single tRNA can influence whether prostate cancer cells mutate and become difficult to treat with standard therapies.

insideprecisionmedicine.com
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Thanks @RuggeroDavide!
Davide Ruggero@RuggeroDavideOct 8
Exciting new study from Andrew Hsieh @HsiehLab and team, revealing how a single tRNA can influence cancer cell identity, lineage plasticity, and therapeutic resistance. Another fascinating example of how the translation control specificity plays a much broader role in cancer!
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A @Nature study led by @yeonsookim_phd in the @HsiehLab at Fred Hutch reveals that a single transfer RNA (tRNA) helps determine whether prostate cancer remains treatment-sensitive or becomes resistant, opening new avenues in precision oncology. bit.ly/4zG67xV

Key driver of aggressive prostate cancer identified, suggesting new way to reverse drug resistance

Researchers at Fred Hutch Cancer Center have identified a previously overlooked molecular regulator that helps determine whether prostate tumors remain sensitive to treatment or evolve into a more...

fredhutch.org
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Tao Pan @UofC played a very important role in this project showing us the conceptual and potential mechanistic beauty of studying tRNA. I’m grateful that @arvind_rasi introduced us many years ago @ @GordonConf. Thank you @SusanLAckerman1 @UCSD for providing the n-Trtct2 mice.
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This work was funded by @fredhutch, @theNCI, @PCFnews @PCF_Science, @AmericanCancer, @CDMRP, the Larry & Virginia Gordon Endowed Chair, and the Mathews Family, Stinchcomb Family, and Thomas & Patricia Wright memorial funds.
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I’m pleased to share our new co-authored paper, now published in Cell Commun Signaling. We found that extracellular vesicles released by sympathetic neuron-like cells promote metastatic traits in breast cancer cells by inducing a hybrid EMT-like state. doi.org/10.1186/s12964-026-0…

Sympathetic nerve–derived extracellular vesicles promote metastatic traits in breast cancer via...

Cell Communication and Signaling - Emerging evidence suggests that the autonomic nervous system contributes to tumor progression, although the molecular mechanisms underlying nerve–tumor...

link.springer.com
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