Physician-scientist at @CRI_UTSW with a focus on #LiverCancer and organ regeneration.
Dallas, TX
Joined March 2016
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Somatic mutations accumulate in “normal” non-cancerous tissues (blood, skin, liver). But why are mutant clones selected? Do they merely proliferate more, selfishly? Or can clones adapt to disease? Could they protect tissues? We shed light on this: authors.elsevier.com/a/1gua9… 1/10
Hao Zhu Lab retweeted
We are excited to share this new preprint from our amazing postdoc, @luisci22! Luis discovered that liver cancer cells with overactive beta-catenin switch their mitochondrial fuel usage from glucose to fatty acid oxidation—an unexpected rewiring that challenges conventional Warburg metabolism.
Excited to share my new preprint from the @RutterLab! What sets a cell’s metabolic state? Using MPC1 as a readout in a CRISPR screen, we found that β-catenin regulates metabolic state in liver cancer cells, driving a switch from carbohydrate to fat oxidation. 🧵
Hao Zhu Lab retweeted
Interested in studying the origins of lung cancer and regulation of development, cell fate, metabolism in human lung progenitors? All in a rigorous, science-loving, supportive environment?
I'm looking for postdoctoral fellows, students, technicians! DM me.
Please retweet!
We are looking to hire post-doctoral fellows to work on somatic mosaicism, regeneration, and cancer development, please reach out to me if you are interested! @CRI_UTSW
Hao Zhu Lab retweeted
Michelle Hsiang recently received a K24 Midcareer Investigator Award from the National Institute of Allergy and Infectious Diseases. Hsiang spoke with IGHS about what it means for her work mentoring early-career researchers in global health.
globalhealthsciences.ucsf.ed…
Hao Zhu Lab retweeted
Not two cells in our body have exactly the same DNA, making us all genetic mosaics! @SMaHTnetwork is trying to understanding what this mosaicism is doing
Excited to say that our commentary @Goodell_Lab "The Silent Variation Within Us" about SMaHT's first papers is out now! 1/n
Hao Zhu Lab retweeted
Excited to contribute to this @NIH resource on somatic mosaicism now published in cell- expanding frontiers of human genetics! Congrats to the leaders of the initiative! sciencedirect.com/science/ar… @CellCellPress
Hao Zhu Lab retweeted
nature.com/articles/s41586-0… Delighted to share our new study published in Nature. By imaging skin cells in living mice over five months, we uncovered that female stem cells divide in a more coordinated way than in males.
Hao Zhu Lab retweeted
Congratulations to Dr. Daniel Siegwart on receiving the Fritz Eckstein Mid-Career Achievement Award at the 2026 Annual Meeting of the Oligonucleotide Therapeutics Society (OTS)! A well-deserved recognition of his contributions to nucleic acid delivery and therapeutic innovation.
Using spatial transcriptomics and AI to understand how and why cells interact in their microenvironments. Congrats to the team of @TaoWang27112003
Hao Zhu Lab retweeted
Happy to share our latest paper on a developmentally restricted immune axis that supports mammalian heart regeneration. cell.com/action/showPdf?pii=…
Hao Zhu Lab retweeted
Makes sense
science.org/doi/10.1126/scie…
Hao Zhu Lab retweeted
Ever wonder if tRNAs can regulate the identity of a cancer cell?
@HsiehLab @FredHutch postdoc @yeonsookim_phd did and discovered a single tRNA that can control lineage dependency and drug sensitivity in prostate cancer published today @Nature: nature.com/articles/s41586-0…
Hao Zhu Lab retweeted
I think too many people treat AI containment and alignment as an engineering challenge to be solved. As I see it, the problem is far more fundamental, and harder to solve (arguably unsolvable). Understanding why requires understanding evolution. Short thread 🧵
A dangerous myth has gained traction after the recent hacks perpetrated by the AI agents developed by leading companies: That these incidents are just cyber security problems, that it's only a matter of fixing the sandboxes in which they’re trained.
In my latest op-ed for the @FinancialTimes, I share why I believe listening to this narrow perspective would leave us exposed to more similar incidents, while offering solutions for an alternative safer path.
Read my op-ed: [ft.com/content/7afaf77b-b027…]
Hao Zhu Lab retweeted
📢We're hiring! 📢
Join The Mark Foundation as a Scientific Director or Senior Scientific Director (depending on experience & qualifications) and help shape the future of cancer research. Learn more and apply:
themarkfoundation.org/scient…
#ScienceJobs #CancerResearch
Hao Zhu Lab retweeted
The most important briefings of the day.
Karl Deisseroth, professor of bioengineering and of psychiatry and behavioral sciences, shares the news of his Nobel Prize with his kids.
Hao Zhu Lab retweeted
With the new academic year starting, and many people beginning fresh as graduate students, post-docs, or junior faculty, I have been thinking a lot about the core philosophies that govern my own perspectives on science. So I thought I would share.
Welcome to The Tao of Cheese
Hao Zhu Lab retweeted
Preprint by @ManciasLab @DanaFarber_Hale
KRAS inhibition drives adaptive surfaceome remodeling and reveals ALPP/ALPPL2 as a targetable vulnerability in #PancreaticCancer
biorxiv.org/content/10.64898…
The surfaceome of KRASi resistant cells harbors many potential targets for ADCs, TCRs
Hao Zhu Lab retweeted
Approved chronic #HepatitisB therapies rarely result in functional cure.
🥼 Scientists at @nchromabio are tackling this with CRMA-1001; it employs an optimized epigenetic silencer and preclinical findings support its potential for a finite treatment course and functional cure.
Read more in the #OpenAccess article published in @natBME: go.nature.com/4yt1pD9
