Computational Genetics Brigham and Women's Hospital | HMS Developing clinical prediction methods in genomic medicine.
Boston, MA
Joined August 2021
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Cassa Lab retweeted
I’m excited to share REGatta, a project by @James_D_Fife from @CassaLabBWH which uses biobank data to estimate the clinical risk of rare variants within regions of established disease genes – Open access link @AJHGNews authors.elsevier.com/a/1h8Og… 🧵
Congratulations @FedeLuppi2 and @agnestothp on this impressive project to improve pathogenicity prediction using structural and epistatic features in clinically significant genes!
Our preprint is online: DeMAG predicts the effects of variants in clinically actionable genes by integrating structural and evolutionary epistatic features biorxiv.org/content/10.1101/…
Congrats to Federica! @FedeLuppi2 @csbdresden @mpicbg
Cassa Lab retweeted
📢New work from our lab in @NatureComm! Our article describes PepSEq, a high-throughput approach to measure influences of peptide fusion on prime editing efficiency.
🎉Joyful effort by members of our lab led by @minja_bio
nature.com/articles/s41467-0…
Cassa Lab retweeted
New work from our lab showing that use of small molecule inhibitor can change mutational outcomes of both SpCas9-NG and KKH-SaCas9 toward 1-bp insertions.
nature.com/articles/s41467-0…