Paul Lockwood

Goliath at Six Flags Over Georgia: 🎢200 ft tall; top speed 70 mph 🎢6 airtime hills: 175, 129, 118, 79, 56 & 48 ft 🎢Airtime hills can lift riders against their lap bars 🎢Camera after final 3 hills, before final banked left turn 🎢Witnesses say Oct 12 photos show rider displaced from his seat

Thanks, @Grok, for confirming that X’s automated filter labeled my article ‘probable spam.’ My article about questionable gatekeeping apparently came with its own live demonstration. 😂

A Different Way to Think About Cancer Immunotherapy: 🧬Most cancer immunotherapies try to strengthen the immune cells attacking a tumor. CAR-T, for example, genetically modifies conventional T cells so they can better recognize and attack cancer cells. 🎀CRG-150 takes almost the opposite approach. It uses a patient’s own regulatory T cells, or Tregs, which normally suppress immune responses and can be co-opted by tumors to help protect themselves. 🧬Using CRISPR, researchers disrupt NCOA3, the gene that produces SRC-3, in those Tregs. The goal is to reprogram some of the tumor’s “bodyguards” so they help organize an immune attack instead of suppressing one. 🎀The mouse data have been striking. SRC-3-deficient Tregs eliminated established breast tumors, produced strong effects in prostate cancer, and later showed antitumor activity in models of glioblastoma, melanoma, and lung cancer. This is still preclinical. CRG-150 has not yet been tested in patients. 🧬One especially interesting feature: the first human trial does not plan to use lymphodepleting chemotherapy beforehand. The strategy is designed to recruit the patient’s existing immune cells rather than replace them. 🎀The first human Phase 1/2a trial is expected to begin later this year and will include: ▪️Metastatic triple-negative breast cancer ▪️Metastatic hormone receptor-positive/HER2-negative breast cancer ▪️Metastatic prostate cancer 👀This is very early science, and mouse results do not guarantee human success. But as a completely different way of approaching solid-tumor immunotherapy, this is one I’ll be watching closely. #CancerResearch #CancerImmunotherapy #CRISPR #CellTherapy #Tregs #BreastCancer #ProstateCancer #ClinicalTrials kevinmd.com/2026/08/regulato…

Psychiatry’s Hybrid Science: When the Symptoms Are Also the Test The Lindsay Clancy case has brought questions of postpartum mental illness, psychosis, and criminal responsibility back into the spotlight. Some thoughts on: 🔬What psychiatry can measure, and what it must infer 🧠Why a reliable diagnosis is not necessarily a biologically validated one 🔎What happens when symptoms are both the evidence and the diagnosis 🧩Where biology, human experience, and clinical interpretation intersect ⚖️Why these distinctions matter far beyond the clinic, especially in the courtroom Mental illness can be unquestionably real while our diagnostic categories remain scientifically unfinished. #Psychiatry #MentalHealth #Psychosis #ForensicPsychiatry #PostpartumPsychosis #LindsayClancy 👉kevinmd.com/2026/08/the-limi…

The Death Certificate Brick Wall: 🧱Death certificates are not just paperwork. They shape family records, public health data, legal review, and the historical record. 🧱Errors in death certification are not rare, especially with accuracy, completeness, and causal sequencing. 🧱A death certificate should explain why the person died when they did — not just list diagnoses they carried in life. 🧱When the certificate conflicts with medical records, families may have evidence but still no clear path to correction. 🧱Correction often depends on someone with legal authority agreeing to act — and that is where many families hit the brick wall. 👉patientsafetyaction.org/2026…

Loyalty Deserves Loyalty: @elonmusk 🚀In 2024, you said: “If any of my companies goes public, we will prioritize … Tesla. Loyalty deserves loyalty.” 🚀In 2020, you said: “Small retail investors” would be a “top priority” and added: “You can hold me to it.” 🚀If a SpaceX IPO is coming, where are the longtime #TSLA holders who stayed loyal through the tough years? 🚀You left California and called out government leaders when promises weren’t kept. Hold yourself to that same standard. #SpaceXIPO #LoyaltyDeservesLoyalty 🚀

The IVF Lottery: 🧑‍🧑‍🧒Infertility is a recognized medical condition affecting about 1 in 8 couples in the U.S. 🧑‍🧑‍🧒IVF is an established, evidence-based treatment. 🧑‍🧑‍🧒For many patients, insurance coverage already makes treatment possible. 🧑‍🧑‍🧒But for many others, access still depends heavily on geography and insurance design. 🧑‍🧑‍🧒In some states, IVF is treated as routine care. In others, families face tens of thousands of dollars in out-of-pocket costs, putting treatment out of reach for many. ➡️The result is a two-tier system for the same medical condition. #IVF #Infertility #HealthcarePolicy #HealthPolicy #HealthInsurance #AccessToCare kevinmd.com/2026/04/ivf-insu…

Are Major Medical Journals Corrupted By Big Pharma⁉️ 👀Modern medicine is built on published scientific research 👀Industry influence is a real concern 👀But government-controlled publishing is not the answer @kevinmd @NEJM @JAMA_current @TheLancet @RobertKennedyJr My latest piece: kevinmd.com/2026/04/evaluati…

🎄My front yard: Festive. ☃️My husband: Fully committed. @CoachLAFHS #MerryChristmas #HappyHolidays #Christmas #HolidaySeason

💪45 years of service 🥶1980–2025 🛡️Kenmore didn’t build refrigerators … they built warriors 🪦My parents’ refrigerator has officially retired

What Encompass Health Doesn’t Want You to See: 🚨Exposé of hidden dangers: On July 15, 2025, The New York Times + KFF Health News revealed Encompass Health rehab hospitals were dangerous — deadly failures like med errors, ignored alarms, even construction hazards that killed patients. 🚨No public warning: These dangers weren’t disclosed. Families had no way to know the risks. 🚨Systemic safety breakdowns: Regulators cited “immediate jeopardy” violations — the most serious — yet Encompass still sold itself as “quality care.” 🚨National impact: Many Encompass hospitals rank among the worst for preventable readmissions, harming patients. The exposé triggered a 10% stock crash in one day — over $1B lost. Law firms now say investors were misled while patients paid the price. 🚨At its core: This isn’t about Wall Street. It’s about patients who trusted Encompass and instead faced preventable harm and death.

Fire Ecology Meets Infrastructure Loss: 🔥The Dragon Bravo Fire began as a lightning-ignited wildfire managed under a confine-and-contain strategy 🔥Escalating conditions turned it into a disaster 🔥Should we still be using “let-burn” policies in peak fire season? 🔥Lost: 🚫Grand Canyon Lodge (historic main lodge, NRHP-listed) 🚫Dozens of guest cabins 🚫Visitor center #GrandCanyon #WildfirePolicy #DragonBravoFire

Discovered the ice, calculated the risk, and chose maximum chaos … 🥛