@DukeWestLab

The West lab identifies pathogenic mechanisms underlying neurological diseases like Parkinson’s to develop new therapeutics that block disease progression

Joined March 2021
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  • Followers73
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Work led by Arpine Sokratian in Andy West's lab unveils the structural underpinnings of alpha-synuclein pathogenicity: Mouse alpha-synuclein fibrils display unique features compared to humans, impacting disease models. More here: doi.org/10.1126/sciadv.adq35…

Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated...

Commonly used mouse α-synuclein fibrils are structurally and functionally close to human E46K-mutated fibrils.

science.org
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Interesting: @DukeWestLab @LashuelLab & collaborators report the first atomic structure of mouse α-synuclein fibrils, but find altered packing arrangements,⬇️hydrophobicity, &⬆️fragmentation sensitivity & weak immunological responses (vs human a-syn) science.org/doi/10.1126/scia…
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New paper from @DukeWestLab et al present an ultra-sensitive version of a SiMOA (single-molecule array assay) for measures of LRRK2 kinase activity in serum linking #Parkinsons severity to peripheral inflam.; Accurate measures of pT73-Rab10 to total Rab10 molecularneurodegeneration.b…
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West Laboratory retweeted
JCI insight
@JCI_insight8 Dec 2023
#Cover: Gut mucosal cells transfer α-synuclein to the vagus nerve: buff.ly/3RyFyaH The image shows α-synuclein (red) emerging from an enteroendocrine cell (green) onto a vagal neuron (turquoise). @DukeHealth #Gastroenterology #Neuroscience
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New research from @DukeWestLab & collaborators reports that anionic nanoplastic contaminants potently precipitate the formation & propagation of #Parkinsons-associated α-synuclein protein fibrils, through a high-affinity interaction NAC domains in α-syn science.org/doi/10.1126/scia…
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Interesting new commentary from West and Schwarzschild on LRRK2 inhibitors for PD and their journey through the pharma "Valley of Death." #LRRK2 #Parkinsons @DukeWestLab movementdisorders.onlinelibr…
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West Laboratory retweeted
bioRxiv@biorxivpreprint19 Feb 2023
Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase biorxiv.org/cgi/content/shor… #bioRxiv
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Replying to @ASAP_Research
@ASAP_Research @AsapLiddle retreat wrapped up today…what great science was discussed 🤓😍!!!
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West Laboratory retweeted
Duke Research & Innovation@dukeresearch1 Nov 2022
College life in a research lab: two students @DukeNeuro weigh in on how they got here, what they're learning and where they hope to go bit.ly/3fqfZZ4 @DukeWestLab
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West Laboratory retweeted
Sid Chandra@SidTheSciKid_22 Aug 2022
Thrilled to receive an NOA for my F30 grant from @NIHAging! Huge thanks to those that helped with the application and in the first year of my PhD- my PI Bob Vassar (twitterless), Sam Sisodia (twitterless), @DGateLab, @LiddelowSA, @DukeWestLab, @DanielJBrat, @NUMSTP, and others!
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Important new data ties together two key proteins in Parkinson disease: LRRK2 regulates the immune response to alpha-synuclein. A @DukeWestLab - @uab_neurology collaboration, supported by the Alabama Udall Center of Excellence in Parkinson Disease Research. @NINDSnews #Parkinson
Molecular Neurodegeneration@MolNeuro12 Jan 2022
'Pathological #alphasynuclein recruits #LRRK2 expressing pro-inflammatory #monocytes to the brain' Andrew West @DukeU @DavidStandaert @lvolpic @uab_neurology molecularneurodegeneration.b…
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