GWAS whisperer 'Nothing in biology makes sense except in the light of evolution' DMs open Executive Director, Integrative Biology @Pfizer
Joined December 2013
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Love this paper
In #GENETICS, @kauralasoo, @Eric_Fauman, and colleagues show how horizontal pleiotropy can mislead Mendelian randomization to infer implausible causal relationships between an exposure and an outcome. buff.ly/4CAfJUk
Through @kauralasoo's tireless work, this neat story of HAL and sunburn has finally seen the light of day!
academic.oup.com/genetics/ad…
Interestingly variants in HAL have also been associated with risk of sun burn and skin cancer.
genetics.opentargets.org/var…
What's going on here?
The most famous heuristic in mapping gwas snps to genes is
"it's usually the closest gene".
But only slightly less well-known is this:
"consider the colocalized phenotypes."
bsky.app/profile/ericfauman.…
It's not a "shake up".
It is the gutting of science in the United States.
NHGRI director Eric Green is out as Trump NIH shakeup continues statnews.com/2025/03/17/trum…
Eric Fauman (he/him) retweeted
You MAGA geniuses have all the answers & the majority… you don’t need us, remember?
See Trump is breaking through law because he knows they are UTTERLY INCAPABLE of governing. @TeamPelosi didn’t have these problems as speaker… Maybe they just need a woman to help them out, you know Diversity and all.
Eric Fauman (he/him) retweeted
HOLY SHIT, Rep. Jasmine Crockett:
"We are going to be in your faces, we're gonna be on your ass, we're going to make sure you understand that this is what democracy looks like!"
🔥🔥🔥
Eric Fauman (he/him) retweeted
You are totally making things up. I’m not even worth $1 million. Nor even $500k. I don’t even own a house! I am one of the lowest net worth members of Congress, trade no stock, and take no outside income.
My filings are public. I loathe corruption, and your lying is disgusting.
This quoted post is unavailable.
New puzzle on blue sky:
The new MVP GWAS paper introduced many interesting phenotypes including
"Ganglion and cyst of synovium, tendon, and bursa (PheCode 727.4)"
Closest protein coding genes in alphabetical order include FPR1,2&3, HAS1, RPL7P51, SIGLEC5 & 14, SPACA6
Pick one
I don't post here any more. If you want to know about the most extreme p values added to the @GWASCatalog this month follow me here
bsky.app/profile/ericfauman.…
Eric Fauman (he/him) retweeted
One month until the CSHL Biology of Genomes abstract deadline! My all-time fav meeting, and one of the few covering genomics broadly. We have a ✨🤩 lineup of speakers, but it's the abstract talks & posters that make the meeting - send us your best work! meetings.cshl.edu/meetings.a…
